副教授 & 副研究员

张兴旺

副研究员
硕士生导师
0532-58632496
个人简介 科研项目 学术论文 其他介绍

教育背景

博士 起止时间:2010.09-2015.06,毕业院校:中国海洋大学,专业:药物化学

学士 起止时间:2006.09-2010.07,毕业院校:齐鲁工业大学,专业:制药工程


工作经历

起止时间 单位名称 专业技术职务

2022.03至今, 山东大学微生物技术国家重点实验室, 副研究员

2019.03-2022.02,山东大学微生物技术国家重点实验室, 助理研究员

2017.08-2019.02,中国科学院青岛生物能源与过程研究所,助理研究员

2015.07-2017.07,中国科学院青岛生物能源与过程研究所,博士后


研究方向

微生物生物合成、合成生物学

(1)山东大学,青年学者“未来计划”,2022-01至2026-12,在研,主持;

(2)国家自然科学基金委员会,青年科学基金项目,2021-01至2023-12,在研,主持;

(3)山东省自然科学基金委员会,博士基金,2017-08至2019-12,已结题,主持。

(4)青岛市人力资源和社会保障局,博士后应用研究项目,2016-01至2017-06,已结题,主持。

(1) Xingwang Zhang, Xiaokun Xu, Cai You, Chaofan Yang, Jiawei Guo, Moli Sang, Ce Geng, Fangyuan Cheng, Lei Du, Yuemao Shen, Sheng Wang, Haidong Lan, Fan Yang, Yuezhong Li, Ya-Jie Tang, Youming Zhang, Xiaoying Bian*, Shengying Li*, Wei Zhang* Biosynthesis of chuangxinmycin featuring a deubiquitinase-like sulfurtransferase.Angewandte Chemie-International Edition,2021, 60, 24418-24423 (IF: 15.336,VIP文章,faculty opinions推荐文章,NPR研究热点)

(2) Xingwang Zhang, Guo Jiawei, Cheng Fangyuan, Li Shengying*,Cytochrome P450 enzymes in fungal natural product biosynthesis,Natural Product Reports, 2021, 38, 1072-1099 (IF: 13.426,封面文章,高被引论文)

(3) Xingwang Zhang and Shengying Li*, Expansion of chemical space for natural products by uncommon P450 reactions,Natural Product Reports, 2017, 34(9): 1061-1089 (IF: 13.426,封面文章)

(4) Shanmin Zheng, Jiawei Guo, Fangyuan Cheng, Zhengquan Gao, Chunxiao Meng*, Shengying Li*, andXingwang Zhang*, Cytochrome P450s in algae: bioactive natural product biosynthesis and light-driven bioproduction,Acta Pharmaceutica Sinica B, 2022, https://doi.org/10.1016/j.apsb.2022.01.013 (IF: 11.614)

(5) Jiawei Guo, Fengwei Li, Fangyuan Cheng, Li Ma, Xiaohui Liu, Pradeepraj Durairaj, Gang Zhang, Dandan Tang, Xiangtian Long, Wei Zhang, Lei Du,Xingwang Zhang*, and Shengying Li, Bacterial biosynthetic P450 enzyme PikCD50N: A potential biocatalyst for the preparation of human drug metabolites. The Journal of Organic Chemistry.2021, 86, 14563−14571. (IF: 4.354)

(6) Xingwang Zhang#,Ping-Lin Li#, Guo-Fei Qin, Shengying Li, de Voogd Nicole J, Xu-Li Tang* and Guo-Qiang Li*, Isolation and Absolute Configurations of Diversiform C-17, C-21 and C-25 Terpenoids from the Marine Sponge Cacospongia sp.,Marine Drugs, 2019, 17(1):14-28. (IF: 5.118)

(7) Ao Zhu#,Xing-Wang Zhang#, Miao Zhang, Wan Li, Zheng-Yue Ma, Hua-Jie Zhu* and Fei Cao*, Aspergixanthones I–K, New Anti-Vibrio Prenylxanthones from the Marine-Derived FungusAspergillus sp. ZA-01,Marine Drugs, 2018, 16(9), 312-320.(IF: 5.118)

(8) Xingwang Zhang, Zhong Li, Lei Du, George E. Chlipala, Patricia C. Lopez, Wei Zhang, David H. Sherman* and Shengying Li*, Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis,Tetrahedron Letters, 2016, 57(52): 5919-5923. (IF: 2.415)

(9) Xing-Wang Zhang#, Xu-Li Tang#, Bao-sheng Liu, Ping-Lin Li*, Guo-Qiang Li*, Characteristic Steroids from the South China Sea GorgonianMuricella sibogae and Their Cytotoxicities,Chemistry and Biodiversity, 2016, 13: 233-237.(IF: 2.408)

(10) Xing-Wang Zhang#, Xu-Li Tang#, Hong-Rui Yuan, Dan-Qing Feng, Pei Su, Ping-Lin Li* and Guo-Qiang Li*, Two New Eunicellin Diterpenoids from the South China Sea Gorgonian Muricella sibogae and Their Bioactivities, Natural Product Research, 2015, 29(21): 1-6.(IF: 2.861)

(11) Ying Ye #, Lei Du #,Xingwang Zhang, Sean A. Newmister, Morgan McCauley, Juan V. Alegre-Requena, Wei Zhang, Shuai Mu, Atsushi Minami, Amy E. Fraley, Maria L. Adrover-Castellano, Nolan A. Carney, Vikram V. Shende, Feifei Qi, Hideaki Oikawa, Hikaru Kato, Sachiko Tsukamoto, Robert S. Paton, Robert M. Williams*, David H. Sherman* and Shengying Li *, Fungal-derived brevianamide assembly by a stereoselective semi-pinacolase,Nature Catalysis, 2020, 3(6), 497-506. (IF: 41.813)

(12) Zhong Li, Yuanyuan Jiang,Xingwang Zhang, Yimin Chang, Shuai Li, Xiaomin Zhang, Shanmin Zheng, Ce Geng, Ping Men, Li Ma, Ying Yang, Zhengquan Gao, Yajie Tang, and Shengying Li*. Fragrant Venezuelaenes A and B with A 5-5-6-7 Tetracyclic Skeleton: Discovery, Biosynthesis, and Mechanisms of Central Catalysts.ACS Catalysis 2020,10(10): 5846-5851.(IF: 13.084)

(13) Wei Zhang, Lei Du, Zepeng Qu,Xingwang Zhang, Fengwei Li, Zhong Li, Feifei Qi, Xiao Wang, Yuanyuan Jiang, Ping Men, Jingran Sun, Shuangna Cao, Ce Geng, Fengxia Qi, Xiaobo Wan, Changning Liu, and Shengying Li * Compartmentalized Biosynthesis of Mycophenolic Acid.Proceedings of National Academy of Science of the United States of America 2019, 116(27), 13305-13310. (IF: 11.205)

(14) Feifei Qi#, Chao Lei#, Fengwei Li,Xingwang Zhang, Jin Wang, Wei Zhang, Zhen Fan, Weichao Li, Gong-Li Tang, Youli Xiao*, Guoping Zhao and Shengying Li*,Nature Communications, 2018, 9:2342-2351. (IF: 14.919)

(15) Wei Zhang#, Lei Du#, Fengwei Li,Xingwang Zhang, Zepeng Qu, Lei Han, Zhong Li, Jingran Sun, Fengxia Qi, Qiuping Yao, Yue Sun, Ce Geng and Shengying Li*, Mechanistic Insights into Interactions between Bacterial Class I P450 Enzymes and Redox Partners,ACS Catalysis, 2018, 8, 9992–10003. (IF: 13.084)

(16) Lei Du#, Sheng Dong#,Xingwang Zhang, Chengying Jiang, Jingfei Chen, Lishan Yao, Xiao Wang, Xiaobo Wan, Xi Liu, Xinquan Wang, Shaohua Huang, Qiu Cui, Yinggang Feng, Shuang-Jiang Liu* and Shengying Li*. Selective oxidation of aliphatic C–H bonds in alkylphenols by a chemomimetic biocatalytic system,Proceedings of National Academy of Science of the United States of America, 2017, 114(26): E5129–E5137. (IF: 11.205)

(17) Li Ma,Fengwei Li,Xingwang Zhang,Hui Chen,Qian Huang,Jingran Sun,Xiaohui Liu,Tianjian Sun,Bo Fang,Kun Liu,Dandan Tang,Dalei Wu, Wei Zhang,Lei Du,Shengying Li*. Development of MEMS directed evolution strategy for multiplied throughput and convergent evolution of cytochrome P450 enzymes.ScienceChina-Life Science,2022,65(3): 550-560. (IF: 6.038)

(18) Cai You,Fengwei Li,Xingwang Zhang, Li Ma,Yuzhong Zhang,Wei Zhang,Shengying Li*. Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH'involved in mycophenolic acid biosynthesis.TheFEBS Journal, 2021, 288, 5768-5780. (IF: 5.542)

(19) Zhong Li#, Lei Du, Wei Zhang,Xingwang Zhang, Yuanyuan Jiang, Kun Liu, Ping Men, Huifang Xu, Jeffrey L. Fortman, David H. Sherman, Bing Yu, Song Gao, and Shengying Li*. Complete elucidation of the late steps of bafilomycin bosynthesis inStreptomyces lohii,Journal of Biological Chemistry, 2017, 292(17): 7095-7104.(IF:5.157)

(20) Sheng Dong.#,Jingfei Chen#,Xingwang Zhang,Fei Guo,Li Ma,Cai You,Xiao Wang,Wei Zhang,Xiaobo Wan,Shuang-Jiang Liu,Li-Shan Yao,Shengying Li, Lei Du*, andYingang Feng* Structural basis for selective oxidation of phosphorylated ethylphenolsby cytochrome P450 monooxygenase CreJ. Applied and Environmental Microbiology, 2021, 87: e00018-21. (IF: 4.792)

获奖情况

山东大学 微生物技术研究院,2021年度“科研之星”


所获专利

李盛英、张兴旺、郭嘉伟,一种用于制备药物代谢产物的生物酶系统及其应用,中国发明专利,申请号:202110446489.5,2021.4.25.