教育背景
博士 2010.10-2014.12 格罗宁根大学 专业：微生物生理
硕士 2007.09-2010.07 山东大学 专业：微生物
学士 2003.09-2007.07 山东大学 专业：生物技术（生命科学基地）
工作经历
起止时间 单位名称 专业技术职务
2016.12-现在 山东大学微生物技术研究院 副研究员
2015.1-2016.12 格罗宁根大学 博士后
研究方向
丝状真菌蛋白分泌机制研究
丝状真菌天然产物细胞工厂构建
功能糖合成及肠道微生物的代谢研究
科研项目
1. 国家自然科学基金面上项目，31970071，2020.1-2023.12，主持，58万
2. 国家重点研发计划子课题，2019YFA0905703-03，2020.1-2024.12，主持，71万
3. 国家自然科学青年基金，31800047，2019.1-2021.12，主持，25万
4. 山东省自然科学基金博士基金，ZR2018BC006，2018.1-2020.12，主持，10万
5. 山东大学未来学者计划，2018.9-2023.6，主持，50万
6. 中国博士后科学基金面上项目，2017M622186，2017.12-2019.08，主持，5万，已结题
7. 山东大学基本科研业务经费，2017TB0010，2017.1-2019.12, 主持，15万，已结题
代表性论文
Liu L, Xu M, Cao Y, Wang H, Shao J, Xu M, Zhang Y, Wang Y, Zhang W,Meng X*, Liu W (2020) Biochemical Characterization of Xylanases from Streptomyces sp. B6 and Their Application in the Xylooligosaccharide Production from Viscose Fiber Production Waste. J Agric Food Chem 68(10):3184-3194
Meng, X., Liu, H., Xu, W., Zhang, W., Wang, Z., &Liu, W*. (2020). Metabolic engineeringSaccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone. Microb Cell Fact, 19(1), 21.
Zhang F, Liu H,Zhang, T.Pijning T, Yu L, Zhang W, Liu W*, Meng X*. Biochemical and genetic characterization of fungal proline hydroxylase in echinocandin biosynthesis.Appl Microbiol Biotechnol. 2018,102(18):7877-7890.
Meng X, Gangoiti J, Wang X, Grijpstra P, van Leeuwen SS, Pijning T, Dijkhuizen L*. Biochemical characterization of a GH70 protein fromLactobacillus kunkeei DSM 12361 with two catalytic domains involving branching sucrase activity. Appl Microbiol Biotechnol. 2018 Sep;102(18):7935-7950.
Wang L, Zheng F, Zhang W, Zhong Y, Chen G,Meng X*，Liu W (2018)A copper-controlled RNA interference system for reversible silencing of target genes inTrichoderma reesei. Biotechnol Biofuels 11: 33.
Wang Z, An N, Xu W, Zhang W, Meng X*, Chen G, Liu W*. (2018)Functional characterization of the upstream components of the Hog1-like kinase cascade in hyperosmotic and carbon sensing in Trichoderma reesei.Biotechnol Biofuels 11: 97.
Meng X, Gangoiti J,de Kok N,van Leeuwen SS, Pijning T, Dijkhuizen L* (2018) Biochemical characterization of two GH70 family 4,6-α-glucanotransferases with distinct product specificity from Lactobacillus aviarius subsp.aviarius DSM 20655.Food Chem,253:236-246
Meng X, Pijning T, Kralj S, Gerwig GJ, Kamerling JP & Dijkhuizen L* (2017) Characterization of the glucansucrase GTF180 W1065 mutant enzymes producing polysaccharides and oligosaccharides with altered linkage specificity.Food Chemistry,217:81-90 .
Meng X, Gangoiti J, Bai Y, Pijning T, van Leeuwen SS, Dijkhuizen L* (2016)Structure-function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes.Cell Mol Life Sci, 73(14):2681-706.
Meng X, Dobruchowska JM, Pijning T, Gerwig GJ, Dijkhuizen L* (2016) Synthesis of new hyper-branched α-glucans from sucrose byLactobacillus reuteri 180 glucansucrase mutants. J Agric Food Chem, 64 (2), 433–442.
Meng X, Pijning T, Dobruchowska JM, Gerwig GJ, Kamerling JP & Dijkhuizen L* (2016) Structural determiants of alternating (α1→4) and (α1→6) linkage specificity in reuteransucrase ofLactobacillus reuteri. Sci Rep 6:35261
Meng X, Pijning T, Dobruchowska JM, Gerwig GJ, Dijkhuizen L* (2015)Characterization of the functional roles of amino acid residues in acceptor binding subsite +1 in the active site of the glucansucrase GTF180 enzyme of Lactobacillus reuteri 180.J Biol Chem, 290 (50): 30131-30141.
Meng X, Dobruchowska JM, Pijning T, Gerwig GJ, Kamerling JP, Dijkhuizen L* (2015) Truncation of domain V of the multidomain glucansucrase GTF180 ofLactobacillus reuteri 180 heavily impairs its polysaccharide-synthesizing ability. Appl Microbiol Biotechnol, 99 (14):5885-5894.
Meng X, Dobruchowska JM, Gerwig GJ, Kamerling JP, Dijkhuizen L* (2015) Synthesis of oligo- and polysaccharides byLactobacillus reuteri121 reuteransucrase at high concentrations of sucrose. Carbohydr Res, 414:85-92.
Meng X, Dobruchowska JM, Pijning T, López CA, Kamerling JP, Dijkhuizen L* (2014)Residue Leu940 has a crucial role in the linkage and reaction specificity of the glucansucrase GTF180 of the probiotic bacteriumLactobacillus reuteri180. J Biol Chem, 289 (47):32773-32782.
