代表性论文
Chen H#, Zhong L#, Zhou H#, Sun T, Zhong G, Tu Q, Zhuang Y, Bai X, Wang X, Xu J, Xia L, Shen Y, Zhang Y*,Bian X*.Biosynthesis of Glidomides and Elucidation of Different Mechanisms for Formation of β-OH Amino Acid Building Blocks.Angew Chem Int Ed. 2022, 61(35): e202203591.Highlighted as theFrontispiece.
LiuJ, Wang X,DaiG, Zhang Y,Bian X*.Microbial Chassis Engineering Drives Heterologous Production of Complex Secondary Metabolites.Biotechnol Adv. 2022,59: 107966.
Shen Q#, Zhou H#, Dai G, Zhong G, Huo L, Li A, Liu Y, Yang M, Ravichandran V, Zheng Z, Tang YJ, Jiao N, Zhang Y,Bian X*. Characterization of a Cryptic NRPS Gene Cluster in Bacillus velezensis FZB42 Reveals a Discrete Oxidase Involved in Multithiazole Biosynthesis.ACS Catalysis. 2022, 12(6): 3371-3381.HighlightinHot off the PressofNatural Product Reports.
Wang X#, Zheng W#, Zhou H, Tu Q, Tang YJ, Stewart AF*, Zhang Y*,Bian X*. Improved dsDNA recombineering enables versatile multiplex genome engineering of kilobase-scale sequences in diverse bacteria.Nucleic Acids Res. 2022, 50(3): e15.
Zhang X, Xu X, You C, Yang C, Guo J, Sang M, Geng C, Cheng F, Du L, Shen Y, Wang S, Lan H, Yang F, Li Y, Tang YJ, Zhang Y,Bian X*, Li S*, Zhang W*. Biosynthesis of chuangxinmycin featuring a deubiquitinase-like sulfurtransferase.Angew Chem Int Ed. 2021,60(46): 24418-24423. Recommended inFaculty OpinionsandHot off the PressofNatural Product Reports.
Liu J, Zhou H, Yang Z, Wang X, Chen H, Zhong L, Zheng W, Niu W, Wang S, Ren X, Zhong G, Wang Y, Ding X, Müller R, Zhang Y,Bian X*. Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria.Nat Commun. 2021, 12: 4347.被Nat Commun编辑选为“生物技术与方法”高亮文章.
Zhong L#,DiaoX#,Zhang N#, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y*, Wu D*,Bian X*.Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis.Nat Commun.2021, 12: 296.被Nat Commun编辑选为“有机化学与化学生物学”高亮文章.
Liu Y#, Zhou H#, Shen Q, Dai G, Yan F, Li X, Ren X, Sun Q, Tang YJ, Zhang Y,Bian X*. Discovery of Polycyclic Macrolide Shuangdaolides by Heterologous Expression of a Cryptic trans-AT PKS Gene Cluster.Org Lett. 2021. 23(17): 6967-6971.
Ouyang Q, Wang X, Zhang N, Zhong L, Liu J, Ding X, Zhang Y,Bian X*.Promoter screening facilitates heterologous production of complex secondary metabolites in Burkholderiales strains.ACS Synth Biol.2020, 9(2):457-460.
Wang ZJ, Zhou H, Zhong G, Huo L, Tang YJ, Zhang Y*,Bian X*. Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.Org Lett. 2020, 22(3): 939-943.
Zheng W#, Wang X#, Zhou H, Zhang Y*, Li A*,Bian X*. Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters.Microb Biotechnol.2020, 13(2): 397-405.获Microb Biotechnol（2020, 13:1702-1704）的Highlight栏目重点介绍。
Jing X#, Cui Q#, Li X, Yin J, Ravichandran V, Pan D, Fu J, Tu Q, Wang H*,Bian X*, Zhang Y*. Engineering Pseudomonas protegens Pf-5 to improve its antifungal activity and nitrogen fixation.Microb Biotechnol. 2020, 13(1): 118-133.
Huo L, Hug JJ, Fu C,Bian X*, Zhang Y*, Müller R*. Heterologous expression of bacterial natural product biosynthetic pathways.Nat Prod Rep.2019, 36(10):1412-1436.入选ESI热点论文和高被引论文
Wang X#, Zhou H#, Chen H#, Jing X, Zheng W, Li R, Sun T, Liu J, Fu J, Huo L, Li YZ, Shen Y, Ding X, Müller R,Bian X*, Zhang Y*. Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proc Natl Acad Sci U S A. 2018, 115 (18): E4255-E4263.获Curr Opin Microbiol和Curr OpinChemBiol重点推荐。
Bian X#, Tang B#, Yu Y, Tu Q, Gross F, Wang H, Li A, Fu J, Shen Y, Li YZ, Stewart AF, Zhao G, Ding X*, Müller R*, Zhang Y*.Heterologous production and yields improvement of epothilones in the Burkholderiales strain DSM 7029.ACS Chem Biol.2017; 12 (7): 1805-1812. Highlight in Hot off the Press of Natural Product Reports
Bian X, Plaza A, Zhang Y*, Müller R*. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chem Sci.2015, 6(5): 3154-3160,
Bian X, Plaza A, Zhang Y*, Müller R*. Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.J Nat Prod. 2012, 75(9):1652-1655. 2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products
Fu J#,Bian X#, Hu S, Wang H, Huang F, Seibert PM, Plaza A, Xia L, Müller R*, Stewart AF*, Zhang Y*. Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.Nat Biotechnol. 2012, 30(5): 440-446. Highlighted in‘Cover Paper’ and ‘News and Views’ of Nature Biotechnology, and Research Highlighted in Nature Methods
获奖情况
2022年山东省和山东大学优秀博士学位论文指导教师
2022年第十三届青岛市青年科技奖
2021年度微生物技术研究院“科研之星”
2022Natural Product ReportsEmerging Investigator Lectureship提名
2021年第五届微生物技术国家重点实验室青年人才学术交流会优秀报告一等奖
2019年度教育部自然科学二等奖，Red/ET基因组编辑与微生物资源发掘，排名第三
2015年中国微生物学会学术年会优秀学术论文交流奖(中国微生物学会)
2013 DECHMA travel grant for 1st European Conference on Natural Products (德国化学工程与生物技术协会)
2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products (美国生药学会)
所获专利
卞小莹，武大雷，钟林，刁晓彤，张娜，张友明。控制脂肽脂链长度改变的关键氨基酸位点及其突变体和应用，ZL202011423361.9
卞小莹，钟林，张娜，陈汉娜，武大雷，张友明。控制脂肽脂链长度改变的关键交换结构域及其突变体和应用，ZL202011422022.9
卞小莹，王雪，陈汉娜，周海波，张友明。一组伯克氏菌同源重组酶及其表达载体与应用，ZL201710685563.2
卞小莹，张友明，许晓坤。创新霉素生物合成基因簇及其应用，ZL201710146841.7
Y. Zhang, J. Fu,X. Bian, F. Stewart, R. Müller.Heterologous hosts.US 9,580,717 B2
