教育背景

博士2008. 09-2013. 07北京大学前沿交叉学科研究院 定量生物学

学士 2004. 09-2008. 07中国海洋大学海洋生命学院 生物科学

工作经历

2019. 09 至今 山东大学微生物技术研究院/国家重点实验室 教授

2013. 10-2019. 08 德国马克斯普朗克陆地微生物研究所 博士后

研究方向

1.微生物环境感应分子机制的研究与信号分子的发现

2.全新生物传感器的设计、合成及应用

3.肠道微生物与环境及宿主的互作机制

4. 代谢途径在单细胞水平的调控和动力学

1. 2021.01-2024.12国家自然科学基金面上项目，基于杂交受体构建策略的胃肠道病原菌趋化受体的配体发现及功能研究，58万，主持

2. 2020.01-2024.12泰山学者青年专家计划，100万元，主持

3. 2019.09-2024.08山东大学齐鲁青年学者建设经费，100万元，主持

4. 2020.07-2021.07微生物技术国家重点实验室开放课题，幽门螺旋杆菌趋化受体TlpA配体化合物的筛选和功能研究，6万元，合作者

5. 2012.01-2015.12国家自然科学基金面上项目，大肠杆菌化学趋向性分子机制研究，75万元，已结题，参与

1.Bi,S.¹, Jin, F.¹, Sourjik, V. Inverted signaling by bacterial chemotaxis receptors.Nat. Commun., 2018, 9:2927.

2. Bi, S., Sourjik, V. Stimulus sensing and signal processing in bacterial chemotaxis.Curr. Opin. Microbiol., 2018, 45:22-29.

3.Bi, S., Yu, D., Si, G., Luo, C., Li, T., Ouyang, Q., Jakovljevice, V., Sourjik, V., Tu, Y., Lai, L. Discovery of novel chemoeffectors and rational design of Escherichia coli chemoreceptor specificity.Proc. Natl. Acad. Sci. U.S.A., 2013, 110:16814–16819.

4. Chen, X.¹,Bi, S.^1,*, Ma, X., Sourjik, V., Lai, L.* Discovery of a new chemoeffector forEscherichia colichemoreceptor Tsr and identification of a molecular mechanism of repellent sensing.ACS BIO & MED CHEM Au, 2022,https://doi.org/10.1021/acsbiomedchemau.1c00055.

5. Bi, S., Pollard, A. M., Yang, Y., Jin, F., Sourjik, V. Engineering hybrid chemotaxis receptors in bacteria.ACS Synth. Biol.2016, 5:989-1001.

6. Bi, S., Lai, L. Bacterial chemoreceptors and chemoeffectors.Cell. Mol. Life Sci., 2015, 72:691-708.

7. Li, N., X, J., Zhang, X., Shi, N., Liu, W., Wu R., Fan, C., Xu, C.,Bi, S.*，Fan,Y*. A novel dimer-induced AIE material as a nano-sensor for colormetric and ratiometric sensing of Erythromycin and metal ions (Zn²⁺, Cd²⁺and Cu²⁺) with different dissociation and re-aggregation processes and cellular imaging applications.Dyes Pigments.2021, 184:108872.

8.Bi, S., Zhang, N., Zuo J., Zhang, P., Zhang, Z., Guo, F. Synthesis, characterization and electrochemical studies on the interaction mechanism of ternary Cu(II) complex with DNA.Asian. J. Chem., 2013, 25:4025-4028.

9.Bi, S., Wang, A., Bi, C., Fan, Y., Xiao, Y., Liu, S., Wang, Q. Coordination polymer of zinc based on chiral non-racemictrans-N,N‘-bis-

(2-hydroxy-1-naphthalidehydene)-(1R,2R)-Cyclohexa-nediamine: Synthesis, crystal structure, novel coordinational models and anticancer activity.Inorg.Chem. Commun., 2012, 15:167-171.

10. Reyes-Darias, J., García, V., Rico-Jiménez, M., Corral-Lugo, A., Lesouhaitier, O., Juárez-Hernández, D., Yang, Y.,Bi, S., Feuilloley, M., Muñoz-Rojas, J., Sourjik, V., Krell, Tino. Specific gamma-aminobutyrate (GABA) chemotaxis inPseudomonadswith different lifestyle.Mol. Microbiol., 2015, 97:488-501.

11. Si, G., Yang, W.,Bi, S., Luo, C., Ouyang, Q. A parallel diffusion-based microfluidic device for bacterial chemotaxis analysis.Lab Chip, 2012, 12:1389-1394.

获奖情况

2020第四届微生物技术国家重点实验室青年人才学术交流会优秀报告三等奖

2013 - 2015 马克斯普朗克学会奖学金

2007第十届“挑战杯”山东省大学生课外学术科技作品竞赛特等奖（第一位）