医药微生物技术

高翔

教授
博士/硕士生导师
第周苑A座-319室
个人简介 科研项目 学术论文 其他介绍

课题组网站

gaolab.qd.sdu.edu.cn


教育背景

博士起止时间:2007/09-2012/06 毕业院校:清华大学专业:生物学

学士起止时间:2003/09-2007/06 毕业院校:山东大学 专业:生物科学


工作经历

起止时间 单位名称 专业技术职务

2017/07−至今 山东大学 教授

2012/07−2017/07 耶鲁大学 博士后


研究方向

1. 病原微生物致病的分子机制。

2.肠道病原微生物(沙门氏菌)、肠道菌群(拟杆菌)以及宿主之间相互作用的分子机制。

1.双亚利桑那沙门氏菌类伤寒毒素组装模式及致病机制研究,国家自然科学基金委面上项目,2024-2027,主持

2.SK10-ARG-2,横向项目,2023-2024,主持

3.功能微生物(群)及其代谢产物调控动物发育和抗病分子机制子课题,国家重点研发计划,2023-2027,主持

4.肠道菌群互作,国家自然科学基金优秀青年科学基金项目,2022-2024,主持

5.致病微生物Ⅲ型分泌系统结构与功能的研究,国家重点研发计划,政府间国际科技创新合作重点专项,2019-2022,主持

6.沙门氏菌SopD效应蛋白家族功能的研究以及人伤寒沙门氏菌动物模型的优化,国家自然科学基金委面上项目,2018-2021,主持

7.国家海外高层次人才青年项目,2017-2020,主持

8.新型冠状病毒现场快速联合检测技术及装备开发,山东省重点研发计划,2020-2023,参加

9.奶牛乳腺炎病学研究及新型疫苗研制,山东省自然科学基金重大基础研究项目,2019-2024,参加

10.山东省泰山学者(青年项目),2017-2021,主持

11.人体肠道微生物与人类健康,山东大学青年交叉科学创新群体,2020-2023,主持

12.病原微生物的致病机制及抗感染药物的开发,山东大学国际科研合作种子基金,2019-2022,主持

2017年至今

1.Kun Jiang#, Weixun Li#, Ming Tong#, Jinghua Xu#, Zhe Chen#, Yan Yang, Yuanrong Zang, Xuyao Jiao, Chang Liu, Bentley Lim, Xianzhi Jiang, Jiawei Wang, Dalei Wu, Mingyu Wang, Shuangjiang Liu, Feng Shao, andXiang Gao*(2024).Bacteroides fragilisUbiquitin Homologue Drives Intraspecies Bacterial Competition in the Gut Microbiome.Nature Microbiology.9(1):70-84. (#, Co-first author)

2.Zhe Chen, Yiting Shi, Dongdong Wang, Xiaoyu Liu, Xuyao Jiao,Xiang Gao*, Kun Jiang* (2023) Structural Insight intoBacillus thuringiensisSip1Ab Reveals Its Similarity to ETX_MTX2 Family Beta-pore-forming Toxin.Pest Manag Sci.79(11):4264-4273

3.KunJiang#, Zhe Chen#, Yuanrong Zang, Yiting Shi, Chengbin Shang, Xuyao Jiao, Jun Cai,Xiang Gao*(2023)Functional Characterization of Vip3Aa fromBacillus ThuringiensisReveals the Contributions of Specific Domains to Its Insecticidal Activity.J Biol Chem. 299(3):103000.(#, Co-first author)

4.Yunjun Pan#, Guobang Li#, Ruxin Liu, Jiawei Guo, Yunjie Liu, Mingyu Liu, Xingwang Zhang, Luping Chi, Kangwei Xu, Ruibo Wu, Yuzhong Zhang, Yuezhong Li,Xiang Gao*, Shengying Li* (2023) Unnatural Activities and Mechanistic Insights of Cytochrome P450 PikC Gained from Site-specific Mutagenesis by Non-canonical Amino Acids.Nature Communications.14(1):1669.(#, Co-first author)

5.Kun Jiang#, Zhe Chen#, Yiting Shi, Yuanrong Zang, Chengbin Shang, Xi Huang, Jiahe Zang, Zhudong Bai, Xuyao Jiao, Jun Cai,Xiang Gao*(2023) A Strategy to Enhance the Insecticidal Potency of Vip3Aa by Introducing Additional Cleavage Sites to Increase Its Proteolytic Activation Efficiency.Engineering Microbiology. 3(4):100083. (#, Co-first author)

6.Xiaoyu Liu, Zhe Chen, Xuyao Jiao, Xukai Jiang, Jicheng Qiu, Fuping You, Hongan Long, Hongzhi Cao, Casey C. Fowler,Xiang Gao* (2022) Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.mBio.13(1): e0191621.

7.Lili Cao, Yujie Luo, Xuefei Guo, Shengde Liu, Siji Li, Junhong Li, Zeming Zhang, Yingchi Zhao, Qiao Zhang, Feng Gao, Xiong Ji,Xiang Gao, Yunfei Li* and Fuping You*(2022)SAFA Facilitates Chromatin Opening of Immune Genes through Interacting with Nascent Antiviral RNAs.Plos Pathogens. 18(6):e1010599.

8.Jiao Pan, Weiyi Li, Jiahao Ni, Kun Wu, Iain Konigsberg, Caitlyn E. Rivera, Clayton Tincher, Colin Gregory, Xia Zhou, Thomas G. Doak, Heewook Lee, Yan Wang,Xiang Gao, Michael Lynch and Hongan Long*(2022). Rates of Mutations and Transcript Errors in the Foodborne PathogenSalmonella entericasubsp.enterica.Molecular Biology and Evolution.39(4):msac081.

9.Adaobi Ojiakor, Rachel N Gibbs, Zhe Chen,Xiang Gao, Casey C Fowler* (2022). The Evolutionary Diversification of theSalmonella artABToxin Locus.Front Microbiol.13:1016438.

10.Jinghua Xu, Jiuqing Wang, Aijun Liu, Yanqing Zhang*,Xiang Gao* (2021) Structural and Functional Analysis of SsaV Cytoplasmic Domain and Variable Linker States in the Context of the InvA-SsaV Chimeric Protein.Microbiology Spectrum.9(3): e01251-21.

11.Huan Lian#, Kun Jiang#, Ming Tong#, Zhe Chen, Xiaoyu Liu, Jorge E. Galan*, andXiang Gao* (2021)TheSalmonellaEffector Protein SopD targets Rab8 GTPase to positively and negative regulate the inflammatory response.Nature Microbiology.6(3)658-671. (#, Co-first author)

12.Kun Jiang#, Yan Zhang#, Zhe Chen#, Dalei Wu, Jun Cai andXiang Gao* (2020) Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin ofBacillus thuringiensis.Toxins.12: 1-15. (#, Co-first author)

13.Peiyan Wang#, Siji Li#, Yingchi Zhao, Baohuan Zhang, Yunfei Li, Shengde Liu, Hongqiang Du, Lili Cao, Meiling Ou, Xiaohong Ye, Peng Li,Xiang Gao, Penghua Wang, Chunxia Jing, Feng Shao, Guang Yang* and Fuping You* (2019) The GRA15 Protein fromToxoplasma gondiiEnhances Host Defense Responses by Activating theInterferonStimulator STING.J Biol Chem. 294(45): 16494-16508. (#, Co-first author)

14.Lili Cao#, Shengde Liu#, Yunfei Li, Guang Yang, Yujie Luo, Siji Li, Hongqiang Du, Yingchi Zhao, Dandan Wang, Jingxuan Chen, Zeming Zhang, Mo Li, Songying Ouyang,Xiang Gao, Yujie Sun, Zekun Wang, Long Yang, Rongtuan Lin, Penghua Wang and Fuping You* (2019) The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.Cell Host Microbe.26(3): 369-384. (#, Co-first author)

15.Yiqiao Bao, Andrew A. Verdegaal, Brent W. Anderson, Natasha A. Barry, Jing He,Xiang Gao, Andrew L. Goodman (2021) A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria.mBio. 12(4): e00656-21.

16.Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki and Jorge E. Galan* (2017) Evolution of Host Adaptation in theSalmonellaTyphoid Toxin.Nature Microbiology.12, 1592-1599.

17.Casey Fowler, Shu-Jung Chang,Xiang Gao, Tobias Geiger, Gabrielle Stack and Galan, Jorge E*(2017)Emerging Insights into the Biology of Typhoid Toxin.Curr. Opin. Microbiol. 35: 70-77. (invited review paper)

2017年以前

(1)Stefania Spanò#,Xiang Gao#, Sebastian Hannemann#, María Lara-Tejero and Jorge E. Galan* (2016) A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.Cell Host Microbe.19(2):216-26. (#, Co-first author)

(2)Lingquan Deng#, Jeongmin Song#,Xiang Gao#, Jiawei Wang, Hai Yu, Xi Chen, Nissi Varki, Yuko Naito-Matsui, Jorge Galan* and Ajit Varki* (2014) Host Adaptation of a Bacterial Toxin from the Human PathogenSalmonellaTyphi.Cell.159(6):1290-9. (#, Co-first author)

(3)Jeongmin Song#,Xiang Gao#and Jorge E. Galan*(2013) Structure and Function of theSalmonellaTyphi Chimaeric A(2)B(5) Typhoid Toxin.Nature.499(7458):350-4. (#, Co-first author; Highlighted by F1000)

(4)Xiang Gao#, Lijun Zhou#, Xuyao Jiao, Feiran Lu, Chuangye Yan, Xin Zeng, Jiawei Wang and Yigong Shi* (2010) Mechanism of Substrate Recognition and Transport by an Amino Acid Antiporter.Nature.463, 828-832. (#, Co-first author)

(5)Xiang Gao#, Feiran Lu#, Lijun Zhou#, Shangyu Dang, Linfeng Sun, Xiaochun Li, Jiawei Wang and Yigong Shi* (2009) Structure and Mechanism of an Amino Acid Antiporter.Science.324, 1565-1568. (#, Co-first author)

获奖情况

2015年获Blavatnik Regional Award Finalist

2014 年获James Hudson Brown - Alexander B. Coxe Fellowship

2011年获吴瑞奖


学术兼职

山东微生物学会基础微生物专业委员会副主任委员2021-2026

中国生物物理学会肠道菌群分会委员2021-2025

《微生物学通报》编辑委员会编委2021-2026

中国遗传学会微生物遗传专业委员会委员2019-2023

中国病理生理学会系统生物学医学专委会委员2019-2023

Engineering Microbiology杂志执行编委