医药微生物技术

尹贻贞

教授
博士/硕士生导师
个人简介 科研项目 学术论文

教育背景

2011.10-2015.03,日本九州大学药学府,创药科学专业,博士;

2008.09-2011.06,山东大学药学院,药物化学专业,硕士;

2004.09-2008.06,安徽医科大学药学院,药学专业,本科。


工作经历

2020.06-至今,山东大学微生物技术国家重点实验室(微生物技术研究院),教授;

2019.05-2019.12,浙江工业大学绿色制药协同创新中心,校聘教授;

2015.04-2019.03,日本东京大学理学府,特任研究员,日本学术振兴会(JSPS)外国人特别研究员。

研究方向

1.DNA编码非经典环肽库的生物法构建以及基于药物靶标的环肽筛选。

2. 人工核酸用于基因损伤修复机制以及抗肿瘤潜在应用的探讨。

科研项目

1.山东省泰山学者青年专家项目,2021.01-2025.12,主持。

2.厦门大学谱学分析与仪器教育部重点实验室开放课题,2021.01-2022.12,主持。

3. 山东大学“齐鲁青年学者”学科建设经费,2020.06-2025.05,主持。

4.国家青年自然科学基金,2020.01-2022.12,主持。

5. 日本学术振兴促进会(JSPS)外国人特别研究员奖励经费,2016.09-2018.08,主持。

学术论文

1. Huilei Dong, Jinjing Li, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries.J. Am. Chem. Soc. 2022, 144, 5116–5125.

2. Daisuke Hazama,Yizhen Yin, Yoji Murata*, Makoto Matsuda, Takeshi Okamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto, Yuka Kakuchi, Yasuyuki Saito, Takenori Kotani, Yoshihiro Nishimura, Atsushi Nakagawa, Hiroaki Suga*, Takashi Matozaki*. Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy. Cell Chem. Biol. 2020, 27, 1181-1191. (Co-first author)

3.Yizhen Yin, Nobuaki Ochi, Timothy W. Craven, David Baker, Nagio Takigawa, Hiroaki Suga*. De novo carborane-containing macrocyclic peptides targeting human EGFR.J. Am. Chem. Soc. 2019, 141, 19193–19197.

4.Yizhen Yin, Qianran Fei, Weidong Liu, Zhuoru Li, Hiroaki Suga*, Chuanliu Wu*. Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation.Angew. Chem. Int. Edit. 2019, 58, 4880-4885.

5. Alex Vinogradov,Yizhen Yin, Hiroaki Suga*. Macrocyclic peptides as drug candidates: recent progress and remaining challenges.J. Am. Chem. Soc. 2019, 141, 4167-4181.

6. Sayaka Imanishi, Takayuki Katoh,Yizhen Yin, Mituhiro Yamada, Marina Kawai,

Hiroaki Suga*. In Vitro Selection of Macrocyclic D/L-Hybrid Peptides against

Human EGFR.J. Am. Chem. Soc. 2021, 143, 5680–5684.

7. Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini,Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga*, Junichi Takagi*. Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.Nat. Commun. 2021, 12, 1543.

8.Yizhen Yin, Fener Chen*. Targeting human MutT homolog 1 (MTH1) for cancer

eradication: current progress and perspectives. Acta Pharm. Sin. B, 2020, 10, 2259–2271.

9. Changsheng Wu*,Yizhen Yin, Lele Zhu, Youming Zhang, Yue-Zhong Li*. Metagenomic sequencing-driven multidisciplinary approaches to shed light on the untapped microbial natural products.Drug Discov. Today 2022, 27, 730–742.

10. Yahong Tan, Junjie Wu, Lulu Song, Mengmeng Zhang, Christopher John Hipolito, Changsheng Wu, Siyuan Wang*, Youming Zhang,Yizhen Yin*. Merging the Versatile Functionalities of Boronic Acid with Peptides.Int. J. Mol. Sci. 2021, 22, 12958.

11. Jia-Qi Hu, Jing-Jing Wang, Yue-Lan Li, Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen,Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Combining NMR-Based Metabolic Profiling and Genome Mining for the Accelerated Discovery of Archangiumide, an Allenic Macrolide from the Myxobacterium Archangium violaceum SDU8.Org. Lett. 2021, 23, 2114–2119.

12.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferation.Bioorg. Med. Chem. 2016, 24, 3856-3861.

13.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Activities.ChemBioChem 2016, 17, 566-569.

14.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Recognition and excision properties of 8-halogenated-7-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguanosine analogues and Fpg and hOGG1 inhibitors. ChemBioChem 2015, 16, 1190-1198.

15.Yizhen Yin, Yosuke Taniguchi*, Shigeki Sasaki*. Synthesis of 8-Halogenated-7-deaza-2'-deoxyguanosine as an 8-Oxo-2'-deoxyguanosine Analogue and Evaluation of its Base Pairing Properties.Tetrahedron 2014, 70, 2040-2047.

16.Yizhen Yin, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*. Recoverable Pd/C

catalyst mediated dehydrogenation of sterols and an improved synthesis of 1α-hydroxydehydroepiandrosterone.Steroids 2012, 77, 1419–1422.

17.Yizhen Yin, Jian-Ping Li, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*. Advances in the Synthesis of A-Ring 1,7-Enyne Synthons for Active Vitamin D3 Analogues.Curr. Org. Synth. 2011, 8, 374-392.

18. Bing-Lei Gao, Cheng-Mei Zhang,Yi-Zhen Yin, Long-Qian Tang, Zhao-Peng Liu*. Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.Bioorg. Med. Chem. Lett. 2011, 21, 3730-3733.