医药微生物技术

尹贻贞

教授
博士/硕士生导师
个人简介 科研项目 学术论文

教育背景

2011.10-2015.03,日本九州大学药学府,创药科学专业,博士;

2008.09-2011.06,山东大学药学院,药物化学专业,硕士;

2004.09-2008.06,安徽医科大学药学院,药学专业,本科。


工作经历

2020.06-至今,山东大学微生物技术国家重点实验室(微生物技术研究院),教授;

2019.05-2019.12,浙江工业大学绿色制药协同创新中心,校聘教授;

2015.04-2019.03,日本东京大学理学府,特任研究员,日本学术振兴会(JSPS)外国人特别研究员。

研究方向

1.基于无细胞体系的非天然氨基酸的体外核糖体翻译。

2. 抗菌、抗病毒与抗肿瘤环肽的超高通量筛选、合成与活性评估。

3. 人工智能(AI)驱动的环肽药物发现。

科研项目

1.国家自然科学基金面上项目(22277065),2023.01-2026.12,主持。

2.山东省泰山学者青年专家项目,2021.01-2025.12,主持。

3.厦门大学谱学分析与仪器教育部重点实验室开放课题,2021.01-2022.12,主持。

4. 山东大学“齐鲁青年学者”学科建设经费,2020.06-2025.05,主持。

5.国家青年自然科学基金(81903425),2020.01-2022.12,主持。

6. 日本学术振兴促进会(JSPS)外国人特别研究员奖励经费,2016.09-2018.08,主持。

学术论文

1. Huilei Dong, Jinjing Li, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries.J. Am. Chem. Soc. 2022, 144, 5116–5125. (IF:16.383)

2. Daisuke Hazama,Yizhen Yin, Yoji Murata*, Makoto Matsuda, Takeshi Okamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto, Yuka Kakuchi, Yasuyuki Saito, Takenori Kotani, Yoshihiro Nishimura, Atsushi Nakagawa, Hiroaki Suga*, Takashi Matozaki*. Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy. Cell Chem. Biol. 2020, 27, 1181-1191. (Co-first author) (IF:9.039)

3.Yizhen Yin, Nobuaki Ochi, Timothy W. Craven, David Baker, Nagio Takigawa, Hiroaki Suga*. De novo carborane-containing macrocyclic peptides targeting human EGFR.J. Am. Chem. Soc. 2019, 141, 19193–19197. (IF:16.383)

4.Yizhen Yin, Qianran Fei, Weidong Liu, Zhuoru Li, Hiroaki Suga*, Chuanliu Wu*. Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation.Angew. Chem. Int. Edit. 2019, 58, 4880-4885. (IF:16.823)

5. Alex Vinogradov,Yizhen Yin, Hiroaki Suga*. Macrocyclic peptides as drug candidates: recent progress and remaining challenges.J. Am. Chem. Soc. 2019, 141, 4167-4181. (IF:16.383)

6. Sayaka Imanishi, Takayuki Katoh,Yizhen Yin, Mituhiro Yamada, Marina Kawai,

Hiroaki Suga*. In Vitro Selection of Macrocyclic D/L-Hybrid Peptides against

Human EGFR.J. Am. Chem. Soc. 2021, 143, 5680–5684. (IF:16.383)

7. Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini,Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga*, Junichi Takagi*. Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.Nat. Commun. 2021, 12, 1543. (IF:17.694)

8. Junjie Wu, Mengmeng Zhang, Lulu Song, Yahong Tan, Yosuke Taniguchi, Christopher John Hipolito, Youming Zhang*,Yizhen Yin*. Implications of N7-hydrogen and C8-keto on the base pairing, mutagenic potential and repair of 8-oxo-2′-deoxy-adenosine: Investigation by nucleotide analogues.Bioorg. Chem. 2022, 127, 106029. (IF:5.307)

9.Yizhen Yin, Fener Chen*. Targeting human MutT homolog 1 (MTH1) for cancer

eradication: current progress and perspectives. Acta Pharm. Sin. B, 2020, 10, 2259–2271. (IF:14.903)

10. Changsheng Wu*,Yizhen Yin, Lele Zhu, Youming Zhang, Yue-Zhong Li*. Metagenomic sequencing-driven multidisciplinary approaches to shed light on the untapped microbial natural products.Drug Discov. Today 2022, 27, 730–742. (IF:8.369)

11. Yahong Tan, Junjie Wu, Lulu Song, Mengmeng Zhang, Christopher John Hipolito, Changsheng Wu, Siyuan Wang*, Youming Zhang,Yizhen Yin*. Merging the Versatile Functionalities of Boronic Acid with Peptides.Int. J. Mol. Sci. 2021, 22, 12958. (IF:6.208)

12. Jia-Qi Hu, Jing-Jing Wang, Yue-Lan Li, Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen,Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Combining NMR-Based Metabolic Profiling and Genome Mining for the Accelerated Discovery of Archangiumide, an Allenic Macrolide from the Myxobacterium Archangium violaceum SDU8.Org. Lett. 2021, 23, 2114–2119. (IF:6.072)

13.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferation.Bioorg. Med. Chem. 2016, 24, 3856-3861. (IF:3.461)

14.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Activities.ChemBioChem 2016, 17, 566-569. (IF:3.461)

15.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Recognition and excision properties of 8-halogenated-7-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguanosine analogues and Fpg and hOGG1 inhibitors. ChemBioChem 2015, 16, 1190-1198. (IF:3.461)

16.Yizhen Yin, Yosuke Taniguchi*, Shigeki Sasaki*. Synthesis of 8-Halogenated-7-deaza-2'-deoxyguanosine as an 8-Oxo-2'-deoxyguanosine Analogue and Evaluation of its Base Pairing Properties.Tetrahedron 2014, 70, 2040-2047. (IF:2.388)

17.Yizhen Yin, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*. Recoverable Pd/C

catalyst mediated dehydrogenation of sterols and an improved synthesis of 1α-hydroxydehydroepiandrosterone.Steroids 2012, 77, 1419–1422. (IF:2.76)

18.Yizhen Yin, Jian-Ping Li, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*. Advances in the Synthesis of A-Ring 1,7-Enyne Synthons for Active Vitamin D3 Analogues.Curr. Org. Synth. 2011, 8, 374-392. (IF:2.276)

19. Bing-Lei Gao, Cheng-Mei Zhang,Yi-Zhen Yin, Long-Qian Tang, Zhao-Peng Liu*. Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.Bioorg. Med. Chem. Lett. 2011, 21, 3730-3733. (IF:2.94)