医药微生物技术

庞秀华

教授
博士/硕士生导师
0532-58631505/13969188792
个人简介 科研项目 学术论文

教育背景

博士:1996.9-2000.7;华中农业大学;生物化学与分子生物学

硕士:1989.9-1992.7;中国科学院武汉病毒研究所;病毒学

学士:1985.9-1989.7;山东师范大学;普通生物学

 

工作经历

起止时间 单位名称 专业技术职务 

2009.3-至今 山东大学 教授

2004.3-2009.12 University of Texas Health Science Center at Tyler (USA) Instructor, Research associate senior, Post-doc.

2001.5-2004.2 University of Nancy I (France), Post-doc.


研究方向

1. 放线菌的代谢调控及基础生物学

2.放线菌的资源挖掘与利用

3. 微生物的生物降解及应用

4.海洋微生物的酶及应用

科研项目

1,国家重点研发计划(2018YFC0310603),主持(子课题)

2,国家重点研发计划(2016YFA0601303),主持(子课题)

3,国家自然科学基金应急项目(31741001),主持

4,国家自然科学基金面上项目(31470165),主持

5,国家自然科学基金面上项目(81171540),主持

6,国家自然科学基金面上项目(81071328),主持

7,山东省自然科学基金面上项目(ZR2019MC062),主持

8,山东省自然科学基金面上项目(ZR2010HM007),主持

代表性论文

*:通讯作者

Zhu Y, Wang X, Zhang J, Ni X, Zhang X, Tao M, and Pang X*. 2022. wblA is the target of the orphan response regulator OrrA in Streptomyces. Environmental Microbiology.

Zhu Y, Lu T, Ni X, Zhang X, Liu Y, Cui X, and Pang X*. 2022. Mutation of MtrA at the predicted phosphorylation site abrogates its role as a global regulator in Streptomyces venezuelae. Microbiology Spectrum.

Zhu Y, Wang J, Su W, Li A, and Pang X*. 2022. Effects of dual deletion of glnR and mtrA on the expression of nitrogen metabolism genes in Streptomyces venezuelae. Microbial Biotechnology.

Zhu Y, Zhang P, Lu T, Wang X, Li A, Lu Y, Tao M, and Pang X*. 2021. Impact of MtrA on phosphate metabolism genes and the response to altered phosphate conditions in Streptomyces. Environmental Microbiology 23(11):6907-6923.

Liu M, Xu W, Zhu Y, Cui X, and Pang X*. 2021. The response regulator MacR and its potential in improvement of antibiotic production in Streptomyces coelicolor. Current Microbiology 78 (10):3696-3707.

Zhu Y, Lu T, Zhang J, Tao M, and Pang X*. 2020. A novel XRE-family regulator that controls antibiotic production and development in Streptomyces coelicolor. Applied Microbiology and Biotechnology 104 (23):10075-10089.

Zhu Y, Zhang P, Zhang J, Wang J, Lu Y, and Pang X*. 2020. Impact on multiple antibiotic pathways reveals MtrA as a master regulator of antibiotic production in Streptomyces and potentially in other actinobacteria. Applied and Environmental Microbiology 86 (20): e01201-20.

Zhu Y, Xu W, Zhang P, Zhao Z, Sheng D, Ma W, Zhang YZ, Bai L, and Pang X*. 2020. A hierarchical network of four regulatory genes controls production of the polyene antibiotic Candicidin in Streptomyces sp. FR-008. Applied and Environmental Microbiology 86 (9): e00055-20.

Zhu Y, Zhang P, Zhang J, Xu W, Wang X, Wu L, Sheng D, Ma W, Cao G, Chen X, Lu Y, Zhang Y, and Pang X*. 2019. The developmental regulator MtrA binds GlnR boxes and represses nitrogen metabolism genes in Streptomyces coelicolor. Molecular Microbiology 112 (1):29-46.

Liu M, Zhang P, Zhu Y, Lu T, Wang Y, Cao, G, Shi M, Chen X, Tao M, and Pang X*. 2019. Novel Two-Component system MacRS is a pleiotropic regulator that controls multiple morphogenic membrane protein genes in Streptomyces coelicolor. Applied and Environmental Microbiology 85 (4): e02178-18.

Lu T, Zhu Y, Zhang P, Sheng D, Cao G, Pang X*. 2018. SCO5351 is a pleiotropic factor that impacts secondary metabolism and morphological development in Streptomyces coelicolor. FEMS Microbiology Letter 365 (17), fny150.

Zhang P, Wu L, Zhu Y, Liu M, Wang Y, Cao G, Chen XL, Tao M, Pang X*. 2017. Deletion of MtrA inhibits cellular development of Streptomyces coelicolor and alters expression of developmental regulatory genes. Frontiers in Microbiology 8:2013(1-18).

Cao G, Zhang P, Gu Y, Pang X*. 2017. Gene Over expression in Streptomyces hygroscopicus Associated with DNA amplification. Current Microbiology 74:979-86.

Zhao Z, Shi T, Xu M, Brock NL, Zhao YL, Wang Y, Deng Z, Pang X*, Tao M*. 2016. Hybrubins: Bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes. Organic LETTERS 18(3):572-5.

Cao G, Howard ST, Zhang P, Wang X, Chen XL, Samten B, and Pang X*. 2015. EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR. Microbiology 161(3):477-489.

Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, and Pang X*. 2015. Production of the antibiotic FR-008/Candicidin in Streptomyces sp. FR-008 is coregulated by two regulators, FscRI and FscRIV, from different transcription factor families. Microbiology 161(3):539-552.

Zhang P, Wu H, Chen XL, Deng Z, Bai L, and Pang X*. 2014. Regulation of the Biosynthesis of Thiopeptide Antibiotic Cyclothiazomycin by a Transcriptiona1 Regulator SHJG8833 in Streptomyces hygroscopicus 5008. Microbiology 160 (7):1379-1392.

Pang X*, Samten B, Cao G, Wang X, Tvinnereim A, Chen X, and Howard ST. 2013. MprAB regulates the espA operon in Mycobacterium tuberculosis, and modulates ESX-1 function and host cytokine response. Journal of Bacteriology 195(1):66-75.  

Pang X, Howard ST. 2007. Regulation of the alpha-crystallin gene acr2 by the MprAB two-component system of Mycobacterium tuberculosis. Journal of Bacteriology 189(17):6213-21.

Pang X, Vu P, Byrd TF, Ghanny S, Soteropoulos P, Mukamolova GV, Wu S, Samten B, Howard ST. 2007. Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology 153(4):1229-42.  

Aigle B†, Pang X†, Decaris B, Leblond P. 2005. Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the dupliated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens. Journal of Bacteriology 187(7):2491-500.

Pang X, Aigle B, Girardet JM, Mangenot S, Pernodet JL, Decaris B, Leblond P. 2004. Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome. Antimicrobial Agents and Chemotherapy 48(2):575-88.

Pang X, Zhou X, Sun Y, Deng Z. 2002. Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions. Journal of Bacteriology 184(7):1958-65.