医药微生物技术

姜昆

副研究员
硕士生导师
个人简介 科研项目 学术论文

教育背景:

博士2012.7-2018.06南开大学 微生物学

学士2008.09-2012.06曲阜师范大学 生物科学


工作经历:

起止时间 单位名称 专业技术职务

2022-至今,山东大学微生物技术国家重点实验室 副研究员

2018-2022,山东大学微生物技术国家重点实验室 博士后


研究方向:

肠道拟杆菌之间互作的分子机制研究

肠道拟杆菌和宿主之间互作的分子机制研究

杀虫蛋白的杀虫机制研究及改造应用

科研项目:

1.国家自然科学基金面上项目(32372615),2024-2027,在研

2.国家重点研发项目子课题(2023YFA0914301)2024-2028,在研

3.山东大学青年学者未来计划,2023-2027,在研

4.国家自然科学基金青年基金项目(31901943),2020.01-2022.12,结题

5.中国博士后科学基金特别资助(2019T120585),2019.01-2021.07,结题

6.中国博士后科学基金面上项目(2019M652370),2019.01-2020.12,结题

代表性论文:

1.Jiang Kun#, Li, W.#, Tong, M.#, Xu, J.#, Chen, Z.#, Yang, Y., Zang, Y., Jiao, X., Liu, C., Lim, B., Jiang, X., Wang, J., Wu, D., Wang, M., Liu, S. J., Shao, F., & Gao, Xiang*. Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome.Nature microbiology, 2023.

2.Chen Zhe, Shi Yi ting, Wang Dongdong, Liu Xiaoyu, Jiao Xuyao, Gao Xiang*,Jiang Kun*. Structural insight into Bacillus thuringiensis Sip1Ab reveals its similarity to ETX_MTX2 family beta-pore-forming toxin.Pest Manag Sci. 2023

3.Kun Jiang#,*, Zhe Chen#, Yiting Shi, Yuanrong Zang, Chengbin Shang, Xi Huang, Jiahe Zang, Zhudong Bai, Xuyao Jiao, Jun Cai, Xiang Gao*.A strategy to enhance the insecticidal potency of Vip3Aa by introducing additional cleavage sites to increase its proteolytic activation efficiency.Engineering Microbiology, 2023.

4.Jiang Kun#, Chen Zhe#, Zang Yuanrong, Shi Yiting, Shang Chengbin, Jiao Xuyao, Cai Jun, Gao Xiang*.Functional characterization of Vip3Aa from Bacillus thuringiensis reveals the contributions of specific domains to its insecticidal activity.Journal of Biological Chemistry,2023.

5.Lian Huan#,JiangKun#, Tong Ming#, Chen Zhe, Liu Xiaoyu, Jorge E. Galán*, Gao Xiang*. TheSalmonellaeffector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response.Nature Microbiology, 2021.(共同一作

6.Jiang Kun#, Zhang Yan#, Chen Zhe#, Wu Dalei, Cai Jun, Gao Xiang*. Structural and functional insights into the C-terminal fragment of insecticidal Vip3A toxin ofBacillus thuringiensis.Toxins, 2020.

7.Jiang Kun, Hou Xiaoyue, Tan Tongtong, Cao Zhanglei, Mei Siqi, Yan Bing, Chang Jin, Han Lu, Zhao Dan, Cai Jun*. Scavenger receptor-C acts as a receptor forBacillus thuringiensisvegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis.PLoS Pathogens, 2018.

8.Jiang Kun#, Hou Xiaoyue#, Han Lu, Tan Tongtong, Cao Zhanglei, Cai Jun*. Fibroblast Growth Factor Receptor, a Novel Receptor for Vegetative Insecticidal Protein Vip3Aa.Toxins, 2018.

9.Jiang Kun, Mei Si qi, Wang Ting ting, Pan Jin hua, Chen Yue hua, Cai Jun*. Vip3Aa induces apoptosis in cultured Spodoptera frugiperda (Sf9) cells,Toxicon, 2016.

10.Jiang Kun#, Li Li na#, Pan Jin hua, Wang Ting ting, Chen Yue hua, Cai Jun*. YvoA and CcpA repress the expression of chiB in Bacillus thuringiensis,Applied and Environmental Microbiology, 2015.