代表性论文：
1.Sun T#, Liu M#, Li S, Guo J, Liu L, Zhang L,Ma L*, Li S*. Cytochrome P450-catalyzed tetrahydrofuran formation via dual pathways in avermectin biosynthesis.ACS Catal,2025, 15, 3295-3305.
2.Jing X, Gong Y, Diao Z, Ma Y, Meng Y, Chen J, Ren Y, Liang Y, Li Y, Sun W, Zhang J, Ji Y, Cong Z, Li S, Ma B, Cui Z*,Ma L*, Xu J*. Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function by FISH-scRACS-seq.The innovation, 2025, 6(3): 100759
3.Li S, Li Z, Zhang G, Urlacher V,Ma L*, Li S*. Functional analysis of the whole CYPome and Fdxome ofStreptomyces venezuelaeATCC15439.Eng Microbiol, 2024, 4(4): 100166.
4.Zhang G, Du J, Zhang C, Zhao Z, Chen Y, Liu M, Chen J, Fan G,Ma L*, Li S*, Liu K*. Identification of a PET hydrolytic enzyme from the human gut microbiome unveils potential plastic biodegradation in human digestive tract. Int J Biol Macromol, 2024, 283(Pt 3): 137732.
5.Qiu Z#, Liu X#, Yu J, Zhao Y, Zhao GR, Li S, Liu K*, Du L*,Ma L*. Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases. Synth Syst Biotechnol, 2024, 9(2):187-195.
6.Ma L, Sun T, Liu Y, Zhao Y, Liu X, Li Y, Chen X, Cao L, Kang Q, Guo J, Du L, Wang W, Li S*. Enzymatic synthesis of indigo derivatives by tuning P450 BM3 peroxygenases. Synth Syst Biotechnol, 2023, 8(3): 452-461.
7.Liu X#, Li F#, Sun T, Guo J, Zhang X, Zheng X, Du L, Zhang W,Ma L*, Li S. Three pairs of surrogate redox partners comparison for Class I cytochrome P450 enzyme activity reconstitution. Commun Biol, 2022, 5(1): 791.
8.Ma L, Li F, Zhang X, Chen H, Huang Q, Su J, Liu X, Sun T, Fang B, Liu K, Tang D, Wu D, Zhang W, Du L, Li S*. Development of MEMS directed evolution strategy for multiplied throughput and convergent evolution of cytochrome P450 enzymes. Sci China Life Sci, 2022, 65(3): 550-560.
9.Guo J, Li F, Cheng F,Ma L, Liu X, Durairaj P, Zhang G, Tang D, Long X, Zhang W, Du L, Zhang X*, Li S. Bacterial biosynthetic P450 enzyme PikCD50N: a potential biocatalyst for the preparation of human drug metabolites. J Org Chem, 2021, 86(21): 14563-14571.
10.You C, Li F, Zhang X,Ma L, Zhang YZ, Zhang W, Li S*. Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH’involved in mycophenolic acid biosynthesis. FEBS J, 2021, 288, 5768-5780.
11.Li F,Ma L, Zhang X, Chen J, Qi F, Huang Y, Qu Z, Yao L, Zhang W, Kim ES, Li S.Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 fromSebekia benihana. Synth Syst Biotechnol, 2020, 5(3): 236-243.
12.Dong S, Chen J, Zhang X, Guo F,Ma L, You C, Wang X, Zhang W, Wan X, Liu SJ, Yao LS, Li S, Du L*, Feng Y*. Structural basis for selective oxidation of phosphorylated ethylphenolsby cytochrome P450 monooxygenase CreJ. Appl Environ Microbiol, 2021, 87: e00018-21.
13.Li Z, Jiang Y, Zhang X, Chang Y, Li S, Zhang X, Zheng S, Geng C, Meng P,Ma L, Yang Y, Gao Z, Tang YJ, Li S*. Fragrant venezuelaenes A and B with a 5−5−6−7 tetracyclic skeleton: discovery, biosynthesis, and mechanisms of central catalysts. ACS catalysis, 2020, 10, 5846-5851.
14.Li Z#, Jiang Y#, Guengerich FP,Ma L, Li S, Zhang W*. Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications. J Biol Chem. 2020, 295(3): 833-849.
15.Xu H, Liang W, Ning L, Jiang Y, Yang W, Wang C, Qi F,Ma L, Du L, Fourage L, Zhou Y J, Li S*. Directed evolution of P450 fatty acid decarboxylases via high-throughput screening towards improved catalytic activity. ChemCatChem, 2019, 11, 1-6.
16.Yao Q#,Ma L#, Liu L, Ikeda H, Fushinobu S, Li S, Xu LH*. Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) fromStreptomyces avermitilis. J Microbiol Biotechnol, 2017, 27(5): 956-964.
17.Sun Y#,Ma L#, Han D#, Du L, Qi F, Zhang W, Sun J, Huang S, Kim ES*, Li S*.In vitroreconstitution of the cyclosporine specific P450 hydroxylases using heterologous redox partner proteins. J Ind Microbiol Biotechnol, 2017, 44(2): 161-166.
18.Du L,Ma L, Qi F, Zheng X, Jiang C, Li A, Wan X, Liu SJ*, Li S*. Characterization of a unique pathway for 4-cresol catabolism initiated by phosphorylation inCorynebacterium glutamicum. J Biol Chem, 2016, 291(12): 6583-6594.
19.Ma L, Du L, Chen H, Sun Y, Huang S, Zheng X, Kim ES, Li S*. Reconstitution of thein vitroactivity of the cyclosporine-specific P450 hydroxylase fromSebekia benihanaand development of a heterologous whole cell biotransformation system. Appl Environ Microbiol. 2015, 81(18), 6268-6275.
20.Li C#,Ma L#, Mou S, Wang Y, Zheng Z, Liu F, Qi X, An M, Chen H, Miao J*. Cyclobutane Pyrimidine Dimers Photolyase from Extremophilic Microalga: Remarkable UVB Resistance and Efficient DNA Damage Repair, Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2015, 773: 37-42.
21.Liu X#, Song F#,Ma L, Chen C, Xiao X, Ren B, Liu X, Dai H,Piggott AM, Av-Gay Y, Zhang L*, Capon RJ*. Sydowiols A–C:Mycobacterium tuberculosisprotein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus,Aspergillus sydowii.Tetrahedron Letters, 2013, 54(45):6081-6083.
22.Ma L, Liu X, Liang H, Che Y, Chen C, Dai H, Yu K, Liu M, Ma LY, Yang CH, Song F, Wang Y*, Zhang L*. Molecular targets of 14-alpha-lipoyl andrographolide on quorum sensing inPseudomonas aeruginosa. Antimicrob Agents Chemother, 2012, 56(12): 6088-6094.
23.Zeng X, Liu X, Bian J, Pei G, Dai H, Polyak SW, Song F,Ma L, Wang Y*, Zhang L*. Synergistic effect of AL-1 and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin byPseudomonas aeruginosa.Antimicrobial Agents and Chemotherapy, 2011, 55(6): 3015-3017.
24.Ma L, Chen J*, Liu R, Zhang XH, Jiang YA. Mutation of rpoS gene decreased resistance to environmental stresses, synthesis of extracellular products and virulence ofVibrio anguillarum. FEMS Microbiol Ecol, 2009, 70(2): 130-136.
