代表性论文：
1.Wei Zhao, Xiao-Di Zheng, Paula Yun-Zhi Tang, Hong-Mei Li, Xue Liu, Jian-Jiang Zhong, Ya-Jie Tang*. Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination.Medicinal Research Reviews2023, 1:1-31.
2.Ying Cong, Shu-Yue Zhang, Paula Yunzhi Tang, Hong-Mei Li, Xue Liu,Wei Zhao*, Ya-Jie Tang*. Conjugating 4β-NH-(5-aminoindazole)-podophyllotoxin and galectin-1-targeted aptamer for synergistic chemo-immunotherapy of hepatocellular carcinoma.Advanced Healthcare Materials2023, 2203144:1-11.
3.Ying Cong, Shu-Yue Zhang, Hong-Mei Li,Tao Chen,Jian-Jiang Zhong,Wei Zhao*, Ya-Jie Tang*. A truncated DNA aptamer with high selectivity for estrogen receptor-positive breast cancer cells.International Journal of Biological Macromolecules2023, 252:126450.
4.Wei Zhao1, Cong Ying1, Hong-Mei Li, Shengying Li, Yuemao Shen, Qingsheng Qi, Youming Zhang, Yue-zhong Li, Ya-Jie Tang*. Challenges and potential on improving druggability of podophyllotoxin-derived drugs in cancer chemotherapy.Natural Product Reports2021, 38: 470-488. (1with equal contribution to this work)
5.Wei Zhao1, Ying Duan1, Hong-Mei Li,Shengying Li, Yuemao Shen, Youming Zhang, Yue-zhong Li, Ya-Jie Tang*. Triazole/thiadiazole substituted 4'-demethylepipodophyllotoxin derivatives induced apoptosis in HeLa cells by up-regulatingTMEM133.European Journal of Pharmacology2021, 905:174189. (1with equal contribution to this work)
6.Jie Cheng1,Wei Zhao1, Hui Yao1, Yuemao Shen, Youming Zhang, Yue-zhong Li, Qingsheng Qi, Kanokpan Wongprasert,Ya-Jie Tang*. 4,6-O-thenylidene-β-D-glucopyranoside-(2″-acetamido, 3″-acetyl-di-S-5-fluorobenzothizole/5-fluorobenzoxazole)-4'-demethylepipodophyllotoxin as potential antitumor candidate drugs with low toxicityin vivoby reducing DNA toxicity and triggering PI3K/Akt pathway and less inhibition of PI3K.Journal of Medicinal Chemistry2020, 63:2877-2893. (1with equal contribution to this work)
7.Wei Zhao1, Long He1, Tian-Le Xiang,Ya-Jie Tang*. Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.European Journal of Medicinal Chemistry2019, 170:73-86. (1with equal contribution to this work)
8.Qing-Yun Zhang1,Wei Zhao1,Ya-Jie Tang*. Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4'-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of podophyllotoxin.European Journal of Medicinal Chemistry2018, 158:951-964.(1with equal contribution to this work)
9.Wei Zhao1, Chen Zhou1, Ze-Yuan Guan, Fu-Sheng Chen*, Ping Yin*,Ya-Jie Tang*. Structural insights into the inhibition of tubulin by the antitumor agent 4β-S-(1, 2, 4-triazole-3-yl)-podophyllotoxin.ACS Chemical Biology2017,12:746-752. (1with equal contribution to this work)
10.Wei Zhao, Jia-Ke Bai, Hong-Mei Li, Tao Chen, Ya-Jie Tang*. Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity.Scientific Reports2015, 5:10172.
11.Wei Zhao1, Xiao-Hua Wang1, Hong-Mei Li, Shi-Hua Wang, Tao Chen, Zhan-Peng Yuan, Ya-Jie Tang*. Isolation and characterization of polysaccharides with the anti-tumor activity fromTuberfruiting bodies and fermentation system.Applied Microbiology and Biotechnology2014, 98:1991-2002. (1with equal contribution to this work)
12.Wei Zhao1, Lu Chen1, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Zhan-Peng Yuan*, Ya-Jie Tang*. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.Bioorganic & Medicinal Chemistry2014, 22:2998-3007. (1with equal contribution to this work)
13.Wei Zhao1, Dan-Dan Chai1, Hong-Mei Li, Tao Chen,Ya-Jie Tang*. Significance of metal ion supplementation in the fermentation medium on the structure and anti-tumor activity ofTuberpolysaccharides produced byTubersubmerged fermentationProcess Biochemistry2014, 49: 2030-2038. (1with equal contribution to this work)
14.Wei Zhao, Hong-Mei Li, Duan-Ji Wan,Ya-Jie Tang*.Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source.Applied Microbiology and Biotechnology2012, 93:107-115.
15.Wei Zhao, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Duan-Ji Wan, Ya-Jie Tang*. Optimization of a biotransformation process to produce 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin.Process Biochemistry2012, 47:1522-1531.
16.Li Xiao1,Wei Zhao1, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Ya-Jie Tang*. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4′-demethylepipodophyllotoxin derivates with anti-tumor activity by activating ATM/ATR signaling pathways.European Journal of Medicinal Chemistry2014, 80:267-277. (1with equal contribution to this work)
17.Jia-Ke Bai,Wei Zhao, Hong-Mei Li, Ya-Jie Tang*. Novel biotransformation process of podophyllotoxin to 4β-sulfur-substituted podophyllum derivates with anti-tumor activity byPenicillium purpurogenumY.J. Tang.Current Medicinal Chemistry2012, 19:927-936.
18.Ya-Jie Tang*,Wei Zhao, Hong-Mei Li.Novel tandem biotransformation process for the biosynthesis of a novel compound 4-(2, 3, 5, 6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin.Applied and Environmental Microbiology2011, 77:3023-3034.
获奖情况：
2016湖北省自然科学一等奖天然产物生物制造的理论与方法
2014湖北省科技进步一等奖工业微生物发酵关键技术及产业化
所获专利：
Ya-Jie Tang,Wei Zhao.4-Sulfur substituted podophyllotoxin derivatives and preparation method thereof and use thereof (US 11,242,354 B2)
Ya-Jie Tang,Wei Zhao. 4β-anilino substituted podophyllotoxin derivatives preparation method thereof and use thereof (US 11,319,328 B2)
Ya-Jie Tang, Wei Zhao. 4′-Demthylepipodophyllotoxin Derivative, Preparation Method and Use Thereof II (US 8,796,279 B2)
Ya-Jie Tang,Wei Zhao. Sulfur-substituted heterocycles podophyllotoxin derivatives having antitumor activity, method for preparation thereof, and use thereof (EP3686203)
Ya-Jie Tang,Wei Zhao. 4-硫黄置換ポドフィロトキシン系誘導体、その製造方法及び使用(特许第7052018号)
