教育背景
2006/09 - 2011/06 山东大学，微生物学，博士
2009/12 - 2011/02 德国马普生物物理研究所，分子生物学，联合培养博士
2002/09 - 2006/06 山东师范大学，生物科学，学士
工作经历
起止时间 单位名称 专业技术职务
2017.9至今 山东大学微生物技术研究院 副教授
2012.2-2017.8 山东大学生命科学学院 讲师
2012.2-2014.2 山东大学化学与化工学院 博士后
研究方向
1、蛋白质高效合成分泌的途径及调控机制研究
2、基因诱导表达调控机理研究
3、高版本底盘细胞工厂构建及功能产品的高效生产
科研项目
1、国家重点研发计划《工业丝状真菌形态发育和代谢机理研究》子课题
2、国家自然科学基金面上项目《转录辅抑制复合物Cyc8-Tup1在瑞氏木霉纤维素酶基因转录激活中的作用机制》
3、国家自然科学基金青年项目《瑞氏木霉纤维二糖转运蛋白CBT1的结构功能及其在纤维素酶基因诱导表达中的作用机制》
4、山东省优秀中青年科学家奖励基金《瑞氏木霉纤维二糖转运系统在纤维素酶诱导表达中的功能研究》
5、山东省自然科学基金面上项目《里氏木霉氮代谢调控因子TAM1调控纤维素酶基因转录表达的机制研究》
代表性论文
1) Xu WQ, Ren YJ, Xia YX, Liu L, Meng XF, Chen GJ, Zhang WX*, Liu WF.A novel transcriptional repressor specifically regulates xylanase gene 1 in Trichoderma reesei. Biotechnol Biofuels Bioprod. 2023 Oct 27;16(1):161.
2)Yang RF, Wang ZX, Xia YX, Zheng FL, Kang FS, Meng XF, Zhang WX*, Liu WF. Role of the Nitrogen Metabolism Regulator TAM1 in Regulation of Cellulase Gene Expression in Trichoderma reesei. Applied and Environmental Microbiology. 2023 Jan 31;89(1):e0142122.
3)Wu XX, Li FZ, Yang RF, Meng XF, Zhang WX*, Liu WF. Identification of a bidirectional promoter from Trichoderma reesei and its application in dual gene expression. Journal of Fungi. 2022 Oct 10;8(10):1059.
4)Zhang WX1, Guo JQ, Wu XX, Ren YJ, Li CY, Meng XF, Liu WF*. Reformulating the hydrolytic enzyme cocktail of Trichoderma reesei by combining XYR1 overexpression and elimination of four major cellulases to improve saccharification of corn fiber. J Agric Food Chem. 2022 Jan 12;70(1):211-222.
5)Xu WQ, Fang Y, Ding MY, Ren YJ, Meng XF, Chen GJ, Zhang WX*, Liu WF. Elimination of the sugar transporter GAT1 increased xylanase I production in Trichoderma reesei. Frontiers in Microbiology. 2022 Jan 26;13:810066.
6)Zhang WX1, Guo JQ, Wang Z, Li YW, Meng XF, Shen Y, Liu WF*.Improved production of germacrene A, a direct precursor of ß-elemene, in engineered Saccharomyces cerevisiae by expressing a cyanobacterial germacrene A synthase. Microb Cell Fact.2021 Jan 7;20(1):7.
7)Wang L1, Zhang WX1, Cao YL, Zheng FL, Zhao GL, Lv XX, Meng XF, Liu WF*. Interdependent recruitment of CYC8/TUP1 and the transcriptional activator XYR1 at target promoters is required for induced cellulase gene expression in Trichoderma reesei. PLoS Genetics. 2021 Feb 19;17(2):e1009351.
8)An JL, Zhang WX*, Wu WP, Chen GJ, Liu WF. Characterization of a highly stable α-galactosidase from thermophilic Rasamsonia emersonii heterologously expressed in a modified Pichia pastoris expression system. Microbial Cell factories. 2019 Oct 23;18(1):180.
9)Wang L, Lv XX, Cao YL, Zheng FL, Meng XF, Shen Y, Chen GJ, Liu WF*, Zhang WX*. A novel transcriptional regulator RXE1 modulates the essential transactivator XYR1 and cellulase gene expression in Trichoderma reesei. Applied Microbiology and Biotechnology. 2019 Jun;103(11):4511-4523.
10)Wang L, Yang RF, Cao YL, Zheng FL, Meng XF, Zhang WX*, Liu WF*. CLP1, a novel plant Homeo domain protein, participates in regulating cellulase gene expression in the filamentous fungus Trichoderma reesei. Frontiers in Microbiology. 2019 Aug 6;10:1700.
11)Zhou YR, Song XY, Li Y, Shi JC, Shi WL, Chen XL, Liu WF, Liu XM, Zhang WX*, Zhang YZ*. Enhancing peptaibols production in the biocontrol fungus Trichoderma longibrachiatum SMF2 by elimination of a putative glucose sensor. Biotechnology and Bioengineering. 2019 Nov;116(11):3030-3040.
12)Wang X1, Zhang WX1, Zhou H, Chen GJ*, Liu WF*.An extracytoplasmic function sigma factor controls cellulose utilization by regulating the expression of an outer membrane protein in Cytophaga hutchinsonii. Applied and Environmental Microbiology 2019；85(5).
13)Zhang WX1, Kou YB1, Xu JT, Cao YL, Zhao GL, Shao J, Wang H, Wang ZX, Bao XM, Chen GJ, Liu WF*. Two major facilitator superfamily sugar transporters from Trichoderma reesei and their roles in induction of cellulase biosynthesis. Journal of Biological Chemistry. 2013 Nov 15;288(46):32861-72.
