2003-2005 美国麻省理工学院(MIT)博士后
2009 “新世纪百千万人才工程”国家级人选
2012 Spring学术期刊“Bioprocess and Biosystems Engineering”副主编
2014 全国杰出专业技术人才
2014 国家“万人计划”科技创新领军人才
2016 国家杰出青年科学基金
2017 中国化工学会候德榜化工科技创新奖
2024 英国皇家生物学会会士
2024 英国皇家化学学会会士
研究方向：天然药物生物智造
长期致力于“天然药物生物智造”领域的教学与科研，建立了天然产物“新分子、新反应、新药物”上下贯通的“天然药物生物智造”研究新范式，为天然产物“出新率低、成药性差、合成效率低”研究瓶颈的突破提供解决方案。
1.新分子：以鬼臼毒素作为研究对象，基于百万级药靶、千万级活性毒性药代、亿级小分子化合物等数据库，构建预测分子结构改造的多任务学习训练集。基于临床患者需求建立人工智能辅助药物分子设计系统，采用trRosetta、diffusion等算法，全方位迭代学习成药性，自主搭建药物分子智能设计模型。设计靶向性强、高效低毒、生物利用度高的鬼臼类衍生物。
2.新反应：基于化学结构与反应规则相似性的RetroPath2.0等软件及分子设计的逆diffusion结构片段组装过程，构建目标产物生物合成途径的智能设计系统。探究非天然供体引入及其手性控制的酶学机理，建立目标产物人工生物合成途径，实现目标产物的“从无到有”。阐明人工生物合成途径与底盘细胞的适配机制，构建合成效率提升的细胞工厂，实现目标产物的“从低到高”。
3.新药物：以临床价值为导向的新药创制为目标，构建临床肿瘤组织来源的不同分型癌症PDO和PDX药效评价模型，从新分子库中挖掘高活低毒的鬼臼类候选药物。深入开展候选药物的药代/毒代等成药性研究，推进候选药物申报临床试验，努力开发为具有全新抗肿瘤机制I类抗肿瘤新药。
主持科研项目
2017.1-2021.12，天然产物生物制造，国家杰出青年科学基金(21625602)
2019.1-2023.12，含氮杂环鬼臼类候选药物人工合成途径的体内组装，国家自然科学基金重点项目(21838002)
2020.1-2024.12，新天然与人工产物的定向挖掘和高效合成的平台技术，国家重点研发计划“合成生物学”重点专项(2019YFA0905700)
2022.7-2027.6，天然产物生物智造，山东省泰山学者攀登专家(tspd20221101)
科研获奖
2016 湖北省自然科学一等奖，天然产物生物制造的理论与方法
2014 湖北省科技进步一等奖，工业微生物发酵关键技术及产业化
2014 教育部自然科学一等奖，高等真菌和植物的次级代谢物发酵过程调控
2011 湖北省自然科学二等奖，食用菌液体发酵
2010 上海市自然科学二等奖，生化反应工程调控方法研究
2004 教育部自然科学一等奖，生物反应器细胞培养工程研究
1.Shan Wang1,*, Kewen Wu1,Ya-Jie Tang*, Hai Deng*. Dehydroamino acid residues in bioactive natural products. Natural Product Reports 2024, 41: 273-297.(1with equal contribution to this work)
2.Wei Zhao, Xiao-Di Zheng, Paula Yun-Zhi Tang, Hong-Mei Li, Xue Liu, Jian-Jiang Zhong,Ya-Jie Tang*. Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination. Medicinal Research Reviews 2023, 1:1-31.
3.Ying Cong, Shu-Yue Zhang, Paula Yunzhi Tang, Hong-Mei Li, Xue Liu, Wei Zhao*,Ya-Jie Tang*. Conjugating 4β-NH-(5-aminoindazole)-podophyllotoxin and galectin-1-targeted aptamer for synergistic chemo-immunotherapy of hepatocellular carcinoma. Advanced Healthcare Materials 2023, 2203144:1-11.
4.Ying Cong, Shu-Yue Zhang, Hong-Mei Li,Tao Chen,Jian-Jiang Zhong,Wei Zhao*,Ya-Jie Tang*. A truncated DNA aptamer with high selectivity for estrogen receptor-positive breast cancer cells. International Journal of Biological Macromolecules 2023, 252:126450.
5.Wei Zhao1, Cong Ying1, Hong-Mei Li, Shengying Li, Yuemao Shen, Qingsheng Qi, Youming Zhang, Yue-zhong Li,Ya-Jie Tang*. Challenges and potential on improving druggability of podophyllotoxin-derived drugs in cancer chemotherapy. Natural Product Reports 2021, 38: 470-488. (1with equal contribution to this work)
6.Kai-Zhi Jia, Li-Wen Zhu, Xu-Dong Qu, Youming Zhang, Yue-zhong Li, Shengying Li, Yuemao Shen, Qingsheng Qi,Ya-Jie Tang*. EnzymaticO-glycosylation of etoposide aglycone by exploration of the substrate promiscuity for glycosyltransferases. ACS Synthetic Biology 2019, 8:2718-2725.
7.Wei Zhao1, Long He1, Tian-Le Xiang, andYa-Jie Tang*. Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain. European Journal of Medicinal Chemistry 2019, 170:73-86. (1with equal contribution to this work)
8.Li-Wen Zhu,Ya-Jie Tang*.Current advances of succinate biosynthesis in metabolically engineeredEscherichia coli. Biotechnology Advances 2017, 35:1040-1048.
9.Jun-Han Yu1, Li-Wen Zhu1, Shi-Tao Xia1,Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen,Ya-Jie Tang*. Combinatorial optimization of CO2transport and fixation to improve succinate production by promoter engineering. Biotechnology and Bioengineering 2016, 113:1531-1541. (1with equal contribution to this work)
10.Li-Wen Zhu1, Xiao-Hong Li1, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen,Ya-Jie Tang*. Activation ofglyoxylate pathway without the activation ofitsrelated gene in succinate-producing engineeredEscherichia coli. Metabolic Engineering 2013, 20:9-19. (1with equal contribution to this work)
国际发明专利
1.Ya-Jie Tang, Wei Zhao. 4-Sulfur substituted podophyllotoxin derivatives and preparation method thereof and use thereof (US 11,242,354 B2)
2.Ya-Jie Tang, Wei Zhao. 4β-anilino substituted podophyllotoxin derivatives preparation method thereof and use thereof (US 11,319,328 B2)
3.Ya-Jie Tang, Kai-Zhi Jia, Yang-Hua Xu, Quan Zhang, Hong-Mei Li. Methionine lyase encoding gene and biosynthetic method thereof (US 10,308,925 B2)
4.Ya-Jie Tang, Jian-Long Li, Wei Zhao, Hong-Mei Li. Sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof (US 9,828,386 B2)
5.Ya-Jie Tang, Yong Yang, Wei Zhao, Hong-Mei Li. Anilino podophyllin derivative having antitumor activity, method for preparation thereof, and use thereof (US 9,714,254 B2)
6.Ya-Jie Tang, Wei Zhao. 4′-Demthylepipodophyllotoxin derivative, preparation method and use thereof II (US 8,796,279 B2)
7.Ya-Jie Tang. 4′-Demthylepipodophyllotoxin derivative, preparation method and use thereof (US 8,569,309 B2)
8.Ya-Jie Tang, Wei Zhao. Sulfur-substituted heterocycles podophyllotoxin derivatives having antitumor activity, method for preparation thereof, and use thereof (EP3686203)
9.Ya-Jie Tang, Wei Zhao. 4-硫黄置換ポドフィロトキシン系誘導体、その製造方法及び使用(特许第7052018号)
10.Ya-Jie Tang, Wei Zhao. Podophyllotoxin derivative, preparation method and use thereof (PCT/CN2023/10270286.4)
招贤纳士
长期高薪诚聘具有生物学(合成微生物学、结构生物学)、化学(化学生物学、天然产物全合成)、药学等相关研究背景的各类青年才俊(本科生、硕士生、科研助理、科研秘书、博士后、专聘科技人员、预聘制科研教师、齐鲁青年学者、泰山学者、国家四青等)。有意申请者请将详细的个人简历(包含但不限于学习和工作经历、研究工作总结、学术成果及佐证材料等)发送邮件至yajietang@sdu.edu.cn，wei.zhao@sdu.edu.cn。邮件主题请写“申请者姓名+应聘的职位”，经面试考核后择优录取。
