代表性论文：
Wang Hongwei, Gu CarinaMuyao, Xu Sujuan, Wang Hongfeng, Zhao Xiaomin, Gu Lichuan. Measurement of optical density of microbes by multi-light path transmission method. mLife. 2024 Dec 1;3(4):565-572.
Wang Maofeng, Wu Cancan, Liu Nan, Jiang Xiaoqiong, Dong Hongjie, Zhao Shubao, Li Chaonan, Xu Sujuan, Gu Lichuan. Regulation of protein thermal stability and its potential application in the development of thermo-attenuated vaccines. Eng Microbiol. 2024 Jun 25;4(3):100162.
Chen Min, Shang Ye, Cui Wenhao, Wang Xiaomeng, Zhu Jiakun, Dong Hongjie, Wang Hongwei, Su Tiantian, Wang Weiwei, Zhang Kundi, Li Bingqing, Xu Sujuan, Hu Wei, Zhang Fengyu, Gu Lichuan. Molecular mechanism of proteolytic cleavage-dependent activation of CadC-mediated response to acid in E. coli. Commun Biol. 2024 Oct 16;7(1):1335.
Dong Hongjie, Zhang Junmei, Zhang Kundi, Zhang Fengyu, Wang Shuai, Wang Qi, Xu Chao, Yin Kun, Gu Lichuan. The cAMP receptor protein from Gardnerella vaginalis is not regulated by ligands. Commun Biol. 2024 Oct 1;7(1):1233.
Yumeng Xiao, Hongjie Dong, Cancan Wu, Kundi Zhang, Xiaoqiong Jiang, Junyu Chen, Hongwei Wang, Sujuan Xu, Fengyu Zhang*, Lichuan Gu*. Nanobody in a Double “Y”-Shaped Assembly: A Promising Candidate for Lateral Flow Immunoassays. Anal Chem. 2024 May 7;96(18):7130-7137.
Fengyu Zhang, Yipeng Wang, Xiaomeng Wang, Hongjie Dong, Min Chen, Ning Du, Hongwei Wang, Wei Hu, Kundi Zhang*,Lichuan Gu*. RT-IVT method allows multiplex real-time quantification of in vitro transcriptional mRNA production.Commun Biol. 2023 Apr 24;6(1):453.
Kundi Zhang , Mengyao Lu, Xiaoxuan Zhu, Kun Wang, Xuemei Jie, Tan Li, Hongjie Dong, Rongguo Li, Fengyu Zhang*,Lichuan Gu*. Antibiotic resistance and pathogenicity assessment of various Gardnerella sp. strains in local China.Front Microbiol. 2022 Sep 26:13:1009798.
Fengyu Zhang, Bingqing Li, Hongjie Dong, Min Chen, Shun Yao, Jingwen Li, Honghai Zhang, Xiangguo Liu, Hongwei Wang, Nannan Song, Kundi Zhang, Ning Du, Sujuan Xu andLichuan Gu*. YdiV regulates Escherichia coli ferric uptake by manipulating the DNA-binding ability of Fur in a SlyD-dependent manner. Nucleic Acids Res 2020 Sep 25;48(17):9571-9588.
Tiantian Su, Jing He, Ningna Li, Shiheng Liu, Sujuan Xu,Lichuan Gu*. A Rational Designed PslG With Normal Biofilm Hydrolysis and Enhanced Resistance to Trypsin-Like Protease Digestion. Front Microbiol. 2020 May 13;11:760.
Xiaoyan Cong, X Zenglin Yuan, X Yijun Du, Bo Wu, Defen Lu, Xiangju Wu, Youjia Zhang, Feng Li, Bin Wei, Jun Li, Jiaqiang Wu, Sujuan Xu, Jinbao Wang, Jing Qi*, Guijun Shang*, andLichuan Gu*. Crystal structures of porcine STINGCBD–CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J Biol Chem. 2019 Jul 26;294(30):11420-11432.
Zenglin Yuan, Fei Gao, Kun Yin andLichuan Gu*, NrnC, an RNase D-Like Protein From Agrobacterium, Is a Novel Octameric Nuclease That Specifically Degrades dsDNA but Leaves dsRNA Intact. Front Microbiol. 2019, 9:3230
Yongzhen Xia, Kai Li, Jingjing Li, Tianqi Wang,Lichuan Gu* and Luying Xun*. T5 exonuclease-dependent assembly offers a low-cost method for efficient cloning and site-directed mutagenesis. Nucleic acid research, 2019, 47(3):e15.
Feng Wang, Qing He, Jia Yin, Sujuan Xu, Wei Hu* &Lichuan Gu*. BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin.Nature comm., 2018,9:2563.
Feng Wang, Qing He, Kaixuan Su, Tiandi Wei, Sujuan Xu,Lichuan Gu*, Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase,Biochemical Journal, 2018,475(1): 191~205
Huateng Zhang, Jing Su, Yuxin Lin, Haixiu Bai, Jiaxiang Liu, Hui Chen, Lupei Du,Lichuan Gu*, and Minyong Li*. Inhibiting Firefly Bioluminescence by Chalcones.Anal Chem.2017 Jun 6;89(11):6099-6105.
Wenxiao Wu, Jing Su, Chunchao Tang, Haixiu Bai, Zhao Ma, Tianchao Zhang, Zenglin Yuan, Zhenzhen Li, Wenjuan Zhou, Huateng Zhang, Zhenzhen Liu, Yue Wang, Yubin Zhou, Lupei Du,Lichuan Gu*, Minyong Li*. cybLuc: An Effective Aminoluciferin Derivative for Deep Bioluminescence Imaging.Anal Chem.2017 May 2;89(9):4808-4816.
Feng Wang, Qing He, Kaixuan Su, Fei Gao, Yan Huang, Zong Lin, Deyu Zhu*,Lichuan Gu*. The PilZ domain of MrkH represents a novel DNA binding motif.Protein Cell. 2016 Oct;7(10):766-772.
Ying Chen, Shiheng Liu, Cuilan Liu, Yan Huang, Kaikai Chi, Tiantian Su, Deyu Zhu, Jin Peng, Zhijie Xia, Jing He, Sujuan Xu, Wei Hu* &Lichuan Gu*. Dcsbis (PA2771) from Pseudomonas aeruginosa is a highly active diguanylate cyclase with unique activity regulation.Sci Rep.2016 Jul 8;6:29499.
Bin Zhu, Cuilan Liu, Shiheng Liu, HengjiangCong,Lichuan Gu*, Luyan Z. Ma*.Membrane association of SadC enhances its diguanylate cyclase activity to control exopolysaccharides synthesis and biofilm formation in Pseudomonas aeruginosa.Environ Microbiol.2016 Mar 3. doi: 10.1111/1462-2920.13263.
Qing He, Feng Wang, Shiheng Liu, Deyu Zhu, Hengjiang Cong, Fei Gao, Bingqing Li, Hongwei Wang, zong Lin, Jun Liao,Lichuan Gu*.Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase.J Biol Chem.2016 Feb 12;291(7):3668-81.
Shan Yu, Tiantian Su, Shiheng Liu, HUijun Wu, Di Wang, Tianhu Zhao, Zengjun JIn, Wenbin Du, Meijun Zhu, Song Lin Chuan, Liang Yang, Deyu Zhu, andLichuan Gu*, Luyan Ma*.PslG, a self-produced glycosyl hydrolase triggers biofilm disassembly by disrupting exopolysaccharide matrix.Cell Research.2015; 25(12):1352-6.
Shiheng Liu, Tiantian Su, Ying Xu, Cong Zhang, Deyu Zhu, Wenmao Zhang, Jing Su, Kang Wang, Tiandi Wei, Yan Huang, Liming Guo, Sujuan Xu, Ningyi Zhou andLichuan Gu* . Crystal Structure of PnpCD, a Two-subunits Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases.J. Biol. Chem. 2015;290(40):24547-60.
Tiantian Su, Shiheng Liu, Kang Wang, Kaikai Chi, Deyu Zhu, Tiandi Wei, Yan Huang, Liming Guo, Wei Hu, Sujuan Xu,Zong Lin,Lichuan Gu*. The REC domain mediated dimerization is critical for FleQ fromPseudomonas aeruginosato function as a c-di-GMP receptor and flagella gene regulator.J. Structural Biology. 2015;192(1):1-13.
Defen Lu, Guijun Shang, Heqiao Zhang, Qian Yu, Xiaoyan Cong,Jupeng Yuan, Fengjuan He, Chunyuan Zhu, Yanyu Zhao, Kun Yin, Yuanyuan Chen, Junqiang Hu, Xiaodan Zhang, Zenglin Yuan, Sujuan Xu,Wei Hu, Huaixing Cang*,Lichuan Gu*.Structural insights into T6SS effector protein Tse3 and Tse3-Tsi3 fromPseudomonas aeruginosareveal a calcium-dependent and membrane-binding mechanism.Molecular Microbiology,2014, Jun;92(5):1092-112.
Shiheng Liu, Conggang Zhang, Tiantian Su, Tiandi Wei, Deyu Zhu, Kang Wang, Yan Huang, Yuhui Dong, Kun Yin, Sujuan Xu, PingXu* andLichuan Gu*.Crystal structure of DszC from Rhodococcus sp. XP at 1.79 Å.Proteins, 2014, 82(9):1708-20.
Jing Su, Cong Zhang, Junjie Zhang, Tiandi Wei, Deyu Zhu, Ningyi Zhou*,Lichuan Gu*.Crystal structure of the γ-hydroxymuconic semialdehyde dehydrogenase from Pseudomonas sp. strainWBC-3, a key enzyme involved in para-Nitrophenol degradation.BMC Struct Biol. 2013, Nov 19;13:30.
Guijun Shang, Deyu Zhu, Ning Li, Junbing Zhang, Chunyuan Zhu, Defen Lu, Cuilan Liu, Qian Yu, Yanyu Zhao, Sujuan Xu,Lichuan Gu*. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.Nat Struct Mol Biol,2012, 19(7):725-7.10.1038/nsmb.2332.
Wei Cheng, Kun Yin, Defen Lu, Bingqing Li, Deyu Zhu, Yuzhen Chen, Hao Zhang, Sujuan Xu, Jijie Chai,Lichuan Gu*. Structural insights into a uniqueLegionella pneumophilaeffector LidA recognizing both GDP and GTP bound Rab1 in their active state.Plos pathogens,2012, Mar;8(3):e1002528.
Ning Li, Conggang Zhang, Bingqing Li, Xiuhua Liu, Yan Huang, Sujuan Xu,Lichuan Gu*. Unique iron coordination in the iron-chelating molecule vibriobactin helps Vibrio cholera evade the mammalian siderocalin-mediated immune response.J. Biol. Chem. 2012, 287(12):8912-9.
Xiuhua Liu, Qian Du, Zhi Wang, Shiheng Liu, Ning Li, Ying Chen, Chunyuan Zhu, Deyu Zhu, Tiandi Wei, Yan Huang, Sujuan Xu,Lichuan Gu*. Crystal Structure of Periplasmic Catecholate-Siderophore Binding Protein VctP fromVibriocholeraeat1.7 Å Resolution.Febs Letter,2012,586(8):1240-4.
Liu Xiuhua, Gong Jing, Wei Tiandi, Wang Zhi, Du Qian, Zhu Deyu, Huang Yan, Xu Sujuan,Gu Lichuan*.Crystal structure of HutZ, a heme storage protein from Vibrio cholerae: A structural mismatch observed in the region of high sequence conservation. BMC Struct Biol. 2012 Sep 26;12:23.
Shiheng Liu, Conggang Zhang, Ning Li, Bei Niu, Mengyuan Liu, Xiuhua Liu, Tiandi Wei, Deyu Zhu, Yan Huang, Sujuan Xu and Lichuan Gu*.Crystal structure of ISC binding ISC domain of VibB fromVibrio choleraeat atomic resolution: a snapshot right before the enzymatic reaction.Acta Crystallogr D Biol Crystallography,2012,68(Pt 10):1329-38.
Bingqing Li, Ning Li, Feng Wang, Liming Guo, Yan Huang, Xiuhua Liu, Tiandi Wei, Deyu Zhu, Cuilan Liu, Hongfang Pan, Sujuan Xu, Hong-Wei Wang,Lichuan Gu*. Structural insight of a concentration-dependent mechanism by which YdiV inhibitsEscherichia coliflagellum biogenesis and motility.Nucleic acid research, 2012,40(21):11073-85.
Guijun Shang, Xiuhua Liu, Defen Lu, Junbing Zhang, Ning Li, Chunyuan Zhu, Shiheng Liu, Qian Yu, Yanyu Zhao, Heqiao Zhang, Junqiang Hu, Huaixing Cang, Sujuan Xu,Lichuan Gu*. Structural insight into functioning ofPseudomonas aeruginosapeptidoglycan-hydolase Tse1 and its immunity protein Tsi1.Biochemical Journal2012, 448(2):201-11.
Yong Gong, Deyu Zhu, Jingjin Ding, Chuan-Na Dou, Xiaoming Ren, Lichuan Gu, Tao jiang & Dacheng Wang. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5′-adenylated DNA.Nat Struct Mol Biol. 2011, 18(11), 1297-9.
Jing Su, Qiang Wang, Jinhong Feng, Cong Zhang, Deyu Zhu, Tiandi Wei, Wenfang Xu,Lichuan Gu*.Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.Bioorg Med Chem.2011,19(9), 2991-6.
Xiuhua Liu, Qian Du, Zhi Wang, Deyu Zhu, Yan Huang, Ning Li, Sujuan Xu,Lichuan Gu*. Structural and biochemical analysis of EfeB/YcdB from Escherichia coli O157: Asp235 plays different roles in different enzyme-catalyzed processes.J. Biol. Chem. 2011, 286(17), 14922-31.
Linjie Chen, Huayi Wang, Jie Zhang,Lichuan Gu, Niu Huang, Jian-Min Zhou & Jijie Chai. Structural basis for the catalytic mechanism of phosphothreonine lyase.Nature Structural & Molecular Biology.2008,15, 101 - 102
Min Hu,Lichuan Gu, Philip D. Jeffrey, and Yigong Shi. Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.PLoS Biol. 2006 Feb;4(2):e27.
Liang Feng#, Suiping Zhou#,Lichuan Gu#, David A. Gell, Joel P. Mackay, Mitchell J. Weiss, Andrew J. Gow and Yigong Shi. Structure of oxidized -haemoglobin bound to AHSP reveals a protective mechanism for haem.Nature. 2005 Jun 2;435(7042):697-701. (#These authors contributed equally).
Nieng Yan#,Lichuan Gu#, David Kokel*, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, and Yigong Shi. Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4.Mol Cell. 2004 Sep 24;15(6):999-1006. (#These authors contributed equally)
Eric N. Shiozaki,Lichuan Gu, Nieng Yan, and Yigong Shi. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.Mol Cell.2004 May 7;14(3):405-12.
Lichuan Gu, Zhiqing Wang, Shiying Song, Yuyan Shu, Zhengjiong Lin. Crystal structures of an acidic phospholipase A(2) from the venom of Naja Kaouthia.Toxicon. 2002, 40(7):917-22.
Lichuan Gu, Hailong Zhang, Shiying Song, Yuancong Zhou, Zhengjiong Lin. Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus.Acta Crystallogr D Biol Crystallography. 2002, 58(Pt 1):104-10.
