代表性论文
Zhao Shuang,† Feng Ruiying,† Gu Yuan,† Han Liyuan, Cong Xiaomei, Liu Yang, Liu Shuo, Shen Qiyao, Huo Liujie,Yan Fu*. Heterologous expression facilitates the discovery and characterization of marine microbial natural products.Engineering Microbiology, 2023, doi: 10.1016/j.engmic.2023.100137
Liu Yang,† Zhou Haibo,† Zhao Shuang, Hao Xingkun, Dai Guangzhi, Zhong Lin, Ren Xiangmei, Sui Haiyan, Zhang Youming *,Yan Fu *,Bian Xiaoying*. Biosynthesis oftrans-AT PKS-derived Shuangdaolides featuring a trans-acting enzyme for online epoxidation.ACS Chemical Biology, 2023, 18(12): 2474–2484
Liu Renzong, Sun Yi, Ma Meina, Han Liyuan, Gao Sheng, Zhang Youming,Yan Fu*.Aurantimonas marianensissp.nov., isolated from deep-sea sediment of the Mariana Trench.International Journal of Systematic and Evolutionary Microbiology. 2023, 73(4): 005816.
Zhang Songya,† Chen Yunliang,† Zhu Jing, Lu Qiujie, Cryle Max J.,* Zhang Youming *,Yan Fu*.Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces.Natural Product Reports, 2023, 40, 557-594.
Liu Zhiguo, Yashiroda Yoko, Sun Peng, Ma Hai, Wang Yanan, Li Li,Yan Fu*, Sun Yi*. Argenteolides A and B, glycosylated polyketide–peptide hybrid macrolides from an actinomyceteStreptomyces argenteolus.Organic Letters, 2023, 25(4): 571−575.
Zhong Guannan,† Wang Zong-Jie,†Yan Fu, Zhang Youming, Huo Liujie*. Recent advances in discovery, bioengineering, and bioactivity-evaluation of ribosomally synthesized and post-translationally modified peptides.ACS Bio & Med Chem Au, 2023, 3 (1): 1-31
Wang Zong-Jie,† Liu Xiaotong,† Zhou Haibo,† Liu Yang, Tu Qiang, Huo Liujie,Yan Fu, Müller Rolf, Zhang Youming,* Xu Xiaokun*. Engineered biosynthesis of complex disorazol polyketides in a streamlinedBurkholderia thailandensis.ACS Synthetic Biology, 2023, DOI: 10.1021/acssynbio.2c00610
Wang Zong-Jie†, Liu Xiaotong†, Zhou Haibo†, Liu Yang, Zhong Lin, Wang Xue, Tu Qiang, Huo Liujie,Yan Fu, Gu Lichuan, Müller Rolf, Zhang Youming*, Bian Xiaoying*, Xu Xiaokun*. Engineering ofBurkholderia thailandensisstrain E264 serves as a chassis for expression of complex specialized metabolites.Frontiers in Microbiology,2022, 13: 1073243.
Zhang Chao, Yu Jing, Tu Qiang,Yan Fu,Hu Zhao, Zhang Youming*, Song Chun *. Antioxidant capacities and enzymatic inhibitory effects of different solvent fractions and major flavones from celery seeds produced in different geographic areas in China.Antioxidants, 2022, 11(8), 1542.
Zhang Jingdan, Xu Huizhong, Yang Hu, Li Jia, Xiao Shuai, Hu Shengbiao,Yan Fu, Xia Liqiu *, Zhang Youming *. Screening of a Plesiomonas shigelloides phage and study of the activity of its lysis system.Virus Research, 2021, 306: 198581.
Liu Yang, Zhou Haibo, Shen Qiyao, Dai Guangzhi,Yan Fu, Li Xiaoju, Ren Xiangmei, Sun Qin, Tang Ya-Jie , Zhang Youming, Bian Xiaoying*. Discovery of Polycyclic Macrolide Shuangdaolides by Heterologous Expression of a Cryptic trans-AT PKS Gene Cluster.Organic Letters, 2021, 23(17): 6967-6971.
李瑞娟，赵晓雨，杨润雨，刘洋，颜富，王海龙，张友明，符军*．噬菌体重组酶介导的DNA同源重组工程．微生物学通报. 2021, 48(9): 3230−3248.
Chen Hanna, Sun Tao, Bai Xianping, Yang Jie,Yan Fu, Yu Lei, Tu Qiang, Li Aiying, Tang Yajie, Zhang Youming,* Bian Xiaoying * and Zhou Haibo*. Genomics-driven activation of silent biosynthetic gene clusters inBurkholderia gladioliby screening recombineering system.Molecules, 2021, 26, 700.
Yan Fuand Müller Rolf*.Class I methyltransferase VioH catalyzes unusual SAM cyclization leading to 4-methylazetidinecarboxylic acid formation in vioprolide biosynthesis.ACS Chemical Biology, 2019, 14(1), 99–105.
Yan Fu,# Auerbach David,# Chai Yi, Keller Lena, Tu Qiang, Hüttel Stephan, Glemser Ameli, Grab A. Hanusch, Bach Thorsten, Zhang Youming,* Müller Rolf*. Biosynthesis and heterologous production of vioprolides: rational biosynthetic engineering and unprecedented 4-methylazetidinecarboxylic acid formation.Angewandt Chemie International Edition, 2018, 57(28):8754-8759.
Yan Fu,# Burgard Christian,# Popoff Alexander, Zaburannyi Nestor, Zipf Gregor, Maier Josef, Bernauer S. Hubert, Wenzel C. Silke, Müller Rolf*.Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production.Chemical Science, 2018, 9, 7510-7519.
Auerbach David,#Yan Fu,# Zhang Youming and Müller Rolf*. Characterization of an unusual glycerate esterification process in vioprolide biosynthesis.ACS Chemical Biology, 2018, 13(11), 3123–3130 .
Bian Xiaoying, Plaza Alberto,Yan Fu, Zhang Youming, Müller Rolf*. Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide.Biotechnology and bioengineering, 2015, 112(7):1343-1353.
Yin Jia, Hoffmann Michael, Bian Xiaoying, Tu Qiang,Yan Fu, Xia Liqiu, Ding Xuezhi, Stewart A. Francis, Müller Rolf, Fu Jun, Zhang Youming*. Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster fromStreptomyces albusDSM41398 inStreptomyces coelicolorA3(2).Scientific reports, 2015, 5, 15081.
Yan Fu, Cheng Xing, Ding Xuezhi, Yao Ting, Chen Hanna, Li Wenping, Hu Shengbiao, Yu Ziquan, Sun Yunjun, Zhang Youming, Xia Liqiu*. Improved insecticidal toxicity by fusing Cry1Ac ofBacillus thuringiensiswith Av3 ofAnemonia viridis.Current Microbiology, 2014, 68(5):604-609.
梁毅偈,孙运军,胡胜标,颜富,张旭,白利明,张友明,丁学知,夏立秋*.大肠杆菌Nissle1917 L-天冬酰胺酶Ⅱ基因在大肠杆菌BL21中的表达与抗肿瘤活性.微生物学通报, 2014, 41(4): 607−613.
Zhang Yunlei, Zhang Youming, Xia Liqiu,* Zhang Xiangli, Ding Xuezhi,Yan Fu, Wu Feng.E.coliNissle 1917 targets and cures the primary tumors through expressing azurin protein.Applied Environmental Microbiology, 2012, 78(21):7603-7610.
Li Wenping, Xia Liqiu,* Ding Xuezhi, Lv Yuan, Luo Yushuang, Hu Shengbiao, Yin Jia,Yan Fu. Expression and characterization of a recombinant Cry1Ac crystal protein fused with an insect-specific neurotoxinω-ACTX-Hv1a inBacillus thuringiensis.Gene, 2012, 498(2):323-327.
