科研项目
山东大学齐鲁青年学者学科建设经费，2019-2023，经费100万元，主持，在研。
国家自然科学基金面上项目：无义介导的mRNA降解通路分子Smg6在哺乳动物大脑发育中的功能及其机制研究，2018.01-2021.12， 直接经费60万元，在研，主持。
科技部国家重点研发计划干细胞及转化研究专项子课题：造血干细胞发育、维持与再生的调控机制，2016.7-2020.12，经费144万元，在研，子课题负责人。
国家自然科学基金面上项目：DNA双链断裂修复基因Nbs1在造血干细胞维持和衰老中的功能研究，2015.01-2019.12，直接经费57万元，主持，已结题。
浙江省自然科学基金一般项目：DNA双链断裂修复基因 Nbs1在胚胎造血干细胞中的功能及其机制研究，2016.01-2018.12 , 经费9万元，主持，已结题。
人社部留学回国人员科技项目择优支持，2016.01-2016.12,经费6万元，主持，已结题。
发表论文（*，通讯作者；#，共同第一）
独立工作发表论文列表（2015.09-至今）
1.Wang JP, Chai BH, Yang YL, Chen CY, Ren YX, Li Y, Wang ZQ,Li T*. JADE1 is dispensable for the brain development in mice. 695:149421(2024).Biochem Biophys Res Commun.独立通讯作者
2.Ma X, Li Y, Chen C, Shen Y, Wang H,Li T*. Spatial expression of the NMD factors UPF3A and UPF3B among mouse tissues.Journal of Zhejiang University-Science B (Biomedicine & Biotechnology).24(11):1062-1068 (2023).独立通讯作者
3.Chen C#, Shen Y#, Li L, Ren Y, Wang ZQ,Li T*. UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells.Life Science Alliance. 6(6): e202201589 (2023).独立通讯作者
4.Wang YR, Zong W, Sun WL, Chen CY, Wang ZQ*,Li T*. The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice.Cells.11(17):2715 (2022).共同通讯作者
5.Zong W, Gong YM, Sun WL,Li T, Wang ZQ. PARP1: Liaison of Chromatin Remodeling and Transcription.Cancers.14(17), 4162 (2022).
6.Zhang L, Yang F,Li T,Dayananda B, Lin L, Lin C. Lessons from the diet: Captivity and sex shape the gut microbiota in an oviparous lizard (Calotes versicolor).Ecol Evol.12(2): e8586 (2022).
7.Guerra GM, May D, Kroll T, Koch P, Groth M, Wang ZQ,Li T, Grigaravicius P. Cell Type-Specific Role of RNA Nuclease SMG6 in Neurogenesis.Cells.10(12):3365 (2021).
8.Chen Y, Sun J, Ju Z, Wang ZQ,Li T*. Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.Cell Prolif.54(3): e12972 (2021).独立通讯作者
9.Zhou ZW, Kirtay M, Schneble N, Yakoub G, Ding M, Rüdiger T, Siniuk K, Lu R, Jiang YN,Li T,et al. NBS1 interacts with Notch signaling in neuronal homeostasis.Nucleic Acids Res.48(19):10924-10939 (2020).
10.Wan X, Zhu X, Wang H, Feng Y, Zhou W, Liu P, Shen W, Zhang L, Liu L,Li T, et al. PGC1α protects against hepatic steatosis and insulin resistance via enhancing IL10‐mediated anti‐inflammatory response.FASEB J.4(8):10751-10761 (2020).
11.Zhu X, Shen W, Yao K, Wang H,Li T, Song L, Diao D, Mao G, et al. Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.Circulation Res.125 (7): 707-719 (2019).
12.Diao D#, Wang H#,Li T#,et al. Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan.EMBO Rep.19: e45494 (2018).
13.Han X#, Wei Y#, Wang H#, Wang F, Ju ZY,Li T*. Nonsense -mediated mRNA decay: a ‘nonsense’ pathway makes sense in stem cell biology.Nucleic Acids Res.46 (3): 1038–1051 (2018).独立通讯作者
14.Li T*, Zhou ZW, Ju Z, Wang ZQ. DNA damage response in hematopoietic stem cell ageing.Genomics, Proteomics & Bioinformatics.14(3): 147-154 (2016).独立通讯作者
15.Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Rudolph KL, Liu G,Li T,Ju Z. SIRT6 maintains hematopoietic stem cell homeostasis through the epigenetic regulation of Wnt signaling.Cell Stem Cell.18: 495-507 (2016).
博士后期间发表论文：
16.Liu X, Zong W,Li T, Wang Y, Xu X, Zhou ZW, Wang ZQ. The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1‐βTrCP2‐Cdc25A‐mediated mitotic entry to ensure neurogenesis.EMBO J.36 (24): 3666-3681 (2017).
17.Li T, Shi Y, Wang P, Guachalla LM, Sun B, Joerss T, Chen YS, Groth M, Krueger A, Platzer M, Yang YG, Rudolph KL, Wang ZQ. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.EMBO J.34:1630-1647 (2015). (Highlighted in Lou et al. EMBO J, 34: 1606-1608.)
18.Zhou ZW, Liu C,Li T, et al. An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.PLoS Genet.9(8): e1003702 (2013).
19.Li T, Wang ZQ. Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage.Mech Ageing Dev.132 (8-9), 382-388 (2011).
20.Saidi A,Li T#, Weih F, Concannon P, Wang ZQ. Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V (D) J recombination and T-cell development.Mol Cell Biol.30 (23), 5572-5581 (2010).
