教育背景：

博士2011.08-2016.05德国莱布尼茨研究院衰老研究所，分子生物学

硕士2008.09-2011.07首都师范大学，生物化学与分子生物学

学士2004.09-2008.07青岛大学，生物技术专业

工作经历:

起止时间 单位名称 专业技术职务

2023.09-至今山东大学微生物技术研究院 研究员

2018.06- 2023.08中国科学院动物研究所 助理研究员

2016.06- 2018.01德国莱布尼茨研究院衰老研究所 博士后

研究方向:

1.大脑发育及退行性疾病

2.微生物群特别是肠道菌群和大脑神经发育与疾病的相互作用

科研项目:

1.2025.01-2027.12山东省泰山青年学者项目，主持，在研

2.2023.09-2028.09山东大学齐鲁青年学者计划学科建设经费，主持,在研

3.2020.01-2022.12国家自然科学基金青年项目，FTO在调节人干细胞稳态和衰老中的作用，主持，结题

代表性论文:

一作/通讯作者文章：

1.Yan S^#, Yuan A^#, Shao G, Zhou W, Xu X, Dong M,Liu X*, Li J*. SUMOylation targets O-GlcNAcase to chaperone-mediated autophagy.J Biol Chem, 2025 May 29, 110314.

2.ZhaoJ^#,ShaoG^#,LuX^#,LvZ, Dong M,Liu X*, Li J*. O-GlcNAcylation of RPA2 at S4/S8 antagonizes phosphorylation and regulates checkpoint activation during replication stress.J Biol Chem, 2024 Nov 2;300(12):107956.

3.LiuX^#,JiaoH^#, Zhang B^#,ZhangS,YanK,QuJ*,ZhangW*,YuL*,LiuGH*.Migrasomes trigger innate immune activation and mediate transmission ofsenescence signals across human cells.Life Medicine,2023, 2(6)

4.Liu X^#, Liu Z^#, Wu Z^#, Ren J^#, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*,Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence.Cell. 2023. 186: 1–18.

5.Wang C^#, Yang K^#,Liu X^#, Wang S, Song M, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer.Research.2023 Jul 27;6:0192.

6.Zhang B^#, Yan H^#,Liu X^#, Sun L^#, Ma S, Wang S, Qu J*, Liu GH*, Zhang W*. SenoIndex: S100A8/S100A9 as a novel aging biomarker.Life Medicine. 2023.Volume 2, Issue 4.

7.Liu X^#，Löhnert N^#, Kristofova M, Qing X, Labisch J, Hofmann S, Ehrenberg S, Sannai M, Jörß T, Ori A, Godmann M, Wang ZQ*. The N-terminal BRCT domain determines MCPH1 function in brain development and fertility.Cell Death Dis. 2021. 12(2):143.

8.Li H^#, Wu Z^#,Liu X^#, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W, Song M*, Song E*, Liu GH*. ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.Protein Cell. 2020. 11(9):688-695.

9.Liu X, Zong W, Li T, Wang Y, Xu X, Zhou ZW*, Wang ZQ*. The E3 ubiquitin ligase APC/C^Cdh1degrades MCPH1 to allow βTrCP2-Cdc25A-mediated mitotic entry and neurogenesis.The EMBO J. 2017. 36(24):e201694443.

10.Li J^#*,Liu X^#, Liao J, Tian J, Wang J, Wang X, Zhang J, Xu X*. MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint.JGeneticsGenomics. 2013.40 (11):575-578.

综述以及评价文章

1.Zhan Y, Su W,Liu X*. Gut microbiota dysbiosis: the hidden roles in human aging and age-related diseases.Oral Sci Homeost Med, 2025, 1, 9610012.

2.Nai S, Song J, Su W,Liu X*. Bidirectional Interplay Among NonCoding RNAs, the Microbiome, and the Host During Development and Diseases.Genes, 2025, 16(208).

3.Aging Biomarker Consortium, et al. Biomarkers of aging.Sci China Life Sci. 2023. May;66(5):893-1066.(共一第二十七位)

4.Liu X, Belmonte JCI, Zhang W,Liu GH*. A Beta-Galactosidase Kiss of Death fo

Senescent Cells.Cell Research. 2020. 30(7):556-557.

5.Liu X, Zhou ZW, Wang ZQ*. The DNA damage response molecule MCPH1 in braindevelopment.Acta Biochimica et Biophysica Sinica. 2016. 48 (7):678-85.