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夏永振

教授
博士/硕士生导师
15069110069/0532-58631575
个人简介 科研项目 学术论文 其他介绍

教育背景

1. 2009/10-2011/10,德国明斯特大学,分子微生物技术研究所,联合培养博士

2. 2006/09-2012/07,山东大学,微生物技术国家重点实验室,博士

3. 2002/09-2006/07,山东大学,国家生命科学和技术基地班,学士

工作经历

1. 2019/09- 至今, 山东大学“齐鲁青年学者”,微生物技术国家重点实验室,教授(破格)

2. 2018/09 –2019.08, 山东大学,微生物技术国家重点实验室,副教授

3. 2012/07- 2018.09,山东大学,微生物技术国家重点实验室,讲师

4. 2012/07- 2014/07,山东大学,化学与化工学院,博士后

研究领域

  • 细菌硫代谢与环境微生物学

长期专注于环境硫循环的微生物学机制研究。通过系统性研究异养细菌的硫氧化途径,首次阐明了异养代谢在环境硫循环中的重要贡献,为重新认识微生物驱动的硫元素生物地球化学循环提供了新视角。在硫烷代谢研究中取得突破性进展,建立了细菌硫烷检测的创新方法,系统解析了硫烷在细菌抗逆性、耐药性及群体行为调控中的分子机制,填补了原核细胞硫烷代谢研究的空白。

  • 合成生物学与生物技术创新

致力于将基础研究成果转化为实用技术。在分子生物学技术创新方面,建立了高效低成本的DNA克隆方法和感受态细胞制备技术,并深入解析了大肠杆菌DNA短同源重组的分子机制。在合成生物学应用研究中,开发了基于工程益生菌的尿酸代谢调控技术,解决了肠道低氧环境下尿酸降解的技术难题,为代谢性疾病的微生物疗法提供了新策略。

课题项目

1.2024.01-2027.12,国家自然科学基金面上项目,32370037,探究硫氰酸酶协助硫烷硫参与微生物抗氧化的新活性和新机制,在研,主持;

2.2025.10-2028.09,山东省自然科学基金面上项目,ZR2025MS451,蛋白质多硫化修饰:分子机制与检测方法构建及其在细菌中普遍性的初探,在研,主持;

3.2024.01-2026.12,山东省自然科学基金面上项目,ZR2023MC004,新型过氧化物酶的生化性质、反应机制和生理功能的研究,在研,主持;

4.2024.08-2026.08,高效尿酸降解益生菌剂开发与医用测试,横向技术开发课题,在研,主持;

5.2019/07 - 2024/06,国家重点研发计划,基于成药性特征的微生物天然产物合成生物学创制,已结题,子课题负责人;

6.2020/01 - 2023/12,国家自然科学基金重大研究计划,近海沉积物中硫氧化主要菌群与关键通路的研究,子课题负责人;已结题,主持;

7.2019/07 - 2024/06,国家自然基金国际(地区)合作与交流项目,31961133015,合成塑料降解转化微生物菌群,子课题负责人,已结题,主持;

8.2019/01 - 2022/12,国家自然科学基金面上项目,31870085,一条新型异养细菌H2S氧化途径的调控和代谢机制研究,已结题,主持;

9.2016/01 - 2018.12,国家自然科学基金青年项目,31500047,QuikChangeTM定点突变中具有同源末端线性DNA分子形成机制的研究,已结题,主持;

10.2015/01 - 2017/12,山东省博士基金,2015BSE27054,DNA聚合酶的链置换活性在QuikChangeTM定点突变中的作用及新应用,已结题,主持。

代表性论文:

1.Yuqing Yang, Fan Liu, Dihao Zeng, Zhiyi Chen, Mingyu Wang, Luying Xun*,Yongzhen Xia*;Expressing Vitreoscilla hemoglobin inEscherichia coliNissle 1917 enhances its probiotic potential for alleviating ulcerative colitis,J Control Release,2025 Aug 20:386:114149(5 year IF=11.5).

2.Fan Liu#, Min Wang#,Huaiwei Liu,Xianzhe Gong,Ning Du,Qilong Qin,Yun Tian,Luying Xun*,Yongzhen Xia*;Development and application of a highly specific whole-cell biosensor for supersulfide detection in environmental samples,Biosensors and Bioelectronics,2025Nov,287,117731.(5 year IF=10.1)

3.Zhiyi Chen,Zhiyi Chen, Luying Xun,Yongzhen Xia*, Xianzhe Gong*, Overlooked role of heterotrophic prokaryotes in sulfur oxidation makes the sediment of the Bohai Sea a sufficient sink of hydrogen sulfide, mBio, 2025 Jul 7:e0172225; (5 year IF= 5.9)

4.Tianqi Wang, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*,Oxidants induce Escherichia coli MarR glutathionylation in the presence of glutathione, Redox Biology,2025 Apr 11:83:103629.(5 year IF=13.1)

5.Tianqi Wang, Xiaoju Li, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*,Microorganisms uptake zero-valent sulfur via membrane lipid dissolution of octasulfur and intracellular solubilization as persulfide,Science of the Total Environment,2024 Apr 20:922:170504. (5 year IF=8.7)

6.Tianqi Wang, Guomei Zhong, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*,A common mechanism for rapid transfer of zero-valent sulfur between microbial cells, Science of the Total Environment,2023 Sep 15;891:164461. (5 year IF=8.7)

7.Chao Tang#; Jingjing Tang#;Yuemeng Shen; Menghui Liu; Honglei Liu; Huaiwei Liu; LuyingXun*;Yongzhen Xia*; A sulfide-sensor and a sulfane sulfur-sensor collectively regulate sulfur-oxidation for feather degradation byBacillus licheniformis, Communications Biology, 2023, 6(1): 167-167. (5 year IF=5.8)

8.Mingxue Ran, Qingbin Li, Yufeng Xin, Shaohua Ma, Rui Zhao, Min Wang, Luying Xun*,Yongzhen Xia*, Rhodaneses minimize the accumulation of cellular sulfane sulfur to avoid disulfide stress during sulfide oxidation in bacteria, Redox Biology, 2022 Jul; 53: 102345. (5 year IF=13.1)

9.Rui Zhao, Zimai Li, Yuqing Sun, Wei Ge, Mingyu Wang, Huaiwei Liu, Luying Xun,Yongzhen Xia*,EngineeredEscherichia coliNissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment,Gut Microbes,2022 Jan-Dec; 14(1):2070391. (5 year IF=13.4)

10.Ran Mingxue, Wang Tianqi, Shao Ming, Chen Zhigang, Liu Huaiwei,Xia Yongzhen*, Xun Luying*,Sensitive Method for Reliable Quantification of Sulfane Sulfur in Biological Samples, Analytical Chemistry,2019, 17;91(18):11981-11986 (5 year IF=6.6)

11.Xia Yongzhen, Li Kai, Li Jingjing, Wang Tianqi, Gu Lichuan*, Xun Luying*. T5 exonuclease-dependent assembly offers a low-cost method for efficient cloning and site-directed mutagenesis, Nucleic Acids Research, 2019, 47(3):e15 (5 year IF=16.8)

12.Yongzhen Xia, Chuanjuan Lü, Ningke Hou, Yufeng Xin, Jihua Liu, Honglei Liu*, Luying Xun*, Sulfide production and oxidation by heterotrophic bacteria under aerobic conditions. ISME Journal, 2017, Dec;11(12):2754-2766. (5 year IF=12.5)

其他论文成果:

13.Menghui Liu, Wei Ge, Guomei Zhong, Yuqing Yang, Luying Xun,Yongzhen Xia*;Dual-Plasmid Mini-Tn5 System to Stably Integrate Multicopy of Target Genes inEscherichia coli,ACS Synth Biol,2024 Nov 15;13(11):3523-3538.

14.Guanhua Xuan, Luying Xun,Yongzhen Xia*,MarR family proteins sense sulfane sulfur in bacteria, mLife, 2024 2024 May 15;3(2):231–239.

15.Yuqing Yang, Menghui Liu, Tianqi Wang, Qian Wang, Huaiwei Liu, Luying Xun,Yongzhen Xia*; An Optimized Transformation Protocol forEscherichia coliBW3KD with Supreme DNA Assembly Efficiency; Microbiol Spectr. 2022 Dec 21;10(6):e0249722.

16.Qiaoli Yu, Mingxue Ran, Yuping Xin, Huaiwei Liu, Honglei Liu,Yongzhen Xia*, Luying Xun*; The Rhodanese PspE Converts Thiosulfate to Cellular Sulfane Sulfur inEscherichia coli; Antioxidants (Basel). 2023 May 20;12(5):1127.

17.Huangwei Xu#, Guanhua Xuan#, Huaiwei Liu, Honglei Liu,Yongzhen Xia*, Luying Xun*, Sulfane Sulfur Is an Intrinsic Signal for the Organic Peroxide Sensor OhrR ofPseudomonas aeruginosa, Antioxidants (Basel),2022 Aug 26;11(9):1667.

18.Qiaoli Yu, Mingxue Ran, Yuqing Yang, Huaiwei Liu, Luying Xun*,Yongzhen Xia*, Optimization of a Method for Detecting Intracellular Sulfane Sulfur Levels and Evaluation of Reagents That Affect the Levels inEscherichia coli, 2022 Jul; 11(7): 1292., Antioxidants (Basel).

19.Tianqi Wang, Yuqing Yang, Menghui Liu, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*,Elemental Sulfur Inhibits Yeast Growth via Producing Toxic Sulfide and Causing Disulfide Stress, Antioxidants (Basel)., 2022 Mar 17;11(3):576.

20.Yuqing Yang, Qiaoli Yu, Min Wang, Rui Zhao, Huaiwei Liu, Luying Xun,Yongzhen Xia*,Escherichia coliBW25113 Competent Cells Prepared Using a Simple Chemical Method Have Unmatched Transformation and Cloning Efficiencies, Front Microbiol., 2022 Mar 24;13:838698.

21.Tianqi Wang, Mingxue Ran, Xiaoju Li, Yequn Liu, Yufeng Xin, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, The Pathway of Sulfide Oxidation to Octasulfur Globules in the Cytoplasm of Aerobic Bacteria, Appl Environ Microbiol., 2022 Feb 8;88(3): e0194121.

22.Huangwei Xu, Guanhua Xuan, Huaiwei Liu,Yongzhen Xia*, Luying Xun*,Sulfane Sulfur Is a Strong Inducer of the Multiple Antibiotic Resistance Regulator MarR inEscherichia coli, Antioxidants (Basel)., 2021 Nov 6;10(11):1778.

23.Guanhua Xuan, Chuanjuan Lv, Huangwei Xu, Kai Li, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence inPseudomonas aeruginosaPAO1,Antioxidants (Basel)., 2021 Sep 21;10(9):1498.

24.Yuqing Yang, Tianqi Wang, Qiaoli Yu, Huaiwei Liu, Luying Xun,Yongzhen Xia*, The pathway of recombining short homologous ends inEscherichia colirevealed by the genetic study, Mol Microbiol., 2021 Jun;115(6):1309-1322.

25.Yufeng Xin, Rui Gao, Feifei Cui, Chuanjuan Lü, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, The Heterotrophic BacteriumCupriavidus pinatubonensisJMP134 Oxidizes Sulfide to Sulfate with Thiosulfate as a Key Intermediate,Appl Environ Microbiol.,2020 Oct 28;86(22):e01835-20.

26.Guanhua Xuan, Chuanjuan Lü, Huangwei Xu, Zhigang Chen, Kai Li, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, Sulfane Sulfur is an intrinsic signal activating MexR-regulated antibiotic resistance inPseudomonas aeruginosa, Mol Microbiol., 2020 Dec;114(6):1038-1048.

27.Liu Huaiwei, Fan Kaili, Li Huanjie, Wang Qingda, Yang Yunyun, Li Kai,Xia Yongzhen*, LuyingXun*,Synthetic Gene Circuits EnableEscherichia coliTo Use Endogenous H2S as a Signaling Molecule for Quorum Sensing, ACS Synth Biol. 2019, 20;8(9):2113-2120.

28.Kai Li, Yufeng Xin, Guanhua Xuan, Rui Zhao, Huaiwei Liu,Yongzhen Xia*, Luying Xun*.Escherichia coliuses different enzymes to produce H2S and reactive sulfane sulfur from L-cysteine, Front Microbiol.,2019 Feb 20;10:298.

学术成绩

近5年以通讯作者身份发表SCI论文23篇,其中一区论文9篇,影响因子大于10的论文7篇。研究成果发表在Redox Biology、Gut Microbes、Journal of Controlled Release、Biosensors and Bioelectronics等领域内顶级期刊上,主持国家自然科学基金等国家级科研项目5项,省级项目2项,人才项目1项。

所获专利

(1)一种依赖T5核酸外切酶和PEG8000完成DNA组装的试剂盒及其应用,中国发明专利,ZL201810779148.8.

(2)一种适于制备高效价感受态细胞的缓冲液及其应用,中国发明专利,CN 202110795317.9.

(3)一株适用多种感受态制备方法的高效价大肠杆菌克隆菌株及其应用,中国发明专利,CN202110794350.X.

(4)一种降解尿酸的工程益生菌及其构建方法和应用,中国发明专利,CN202210134048.6.

学术任职与荣誉

中国环境微生物专委会委员,山东大学齐鲁青年学者,山东省高层次人才。