教授 & 研究员

王明钰

教授
博士/硕士生导师
0532-58630856
个人简介 科研项目 学术论文 其他介绍
教育背景

博士 起止时间:2003.08-2010.10毕业院校:宾夕法尼亚州立大学 专业:生物化学、微生物学与分子生物学

学士 起止时间:1999.09-2003.07毕业院校:北京大学 专业:生物科学


工作经历

起止时间 单位名称 专业技术职务

2019.09--今 山东大学 教授

2013.09--2019.08山东大学 副教授

2011.07-2013.08 山东大学 讲师

2010.10-2011.04 宾夕法尼亚州立大学 博士后

研究方向

1.临床及环境耐药性机制与调查;

2. 耐药性及其转移的分子调控机制;

3. 体内体外微生物组模型;

4. 微生物感染相关技术开发


科研项目

27.国家重点研发计划政府间合作专项“抗生素耐药因子的来源、动员和扩散”,2022年10月-2025年9月,No. 2022YFE0199800,任务负责人。

26.横向项目“新型冠状病毒核酸LAMP扩增条件的优化与开发”,2021年3月-2023年12月,负责人。

25.山东省重点研发计划(重大科技创新工程)“新型冠状病毒现场快速联合检测技术及装备开发”,2020年12月—2023年12月,No. 2020CXGC011305,课题负责人

24.山东省自然科学基金面上项目“基于WGS的多重耐药性院内传播途径鉴定与阻断技术”,2021年1月-2023年12月,No. ZR2020MH308,参与

23.山东大学基本科研业务费交叉学科培育项目“医疗废水中耐药性威胁的消除及其机制研究”,No. 2018JC013,2018年1月-2020年12月,参与

22.山东大学基本科研业务费交叉学科培育项目“地球大气层中抗生素耐药基因的分布与传播机制研究”,No. 2018JC027,2018年1月-2020年12月,负责人

21.微生物技术国家重点实验室开放课题“口腔溃疡的微生物学基础”,2018年7月-2019年5月,No. M2018-07,负责人

20.横向课题“体育器材及场所的耐药菌污染”,2018年4月-2020年4月,负责人

19.微生物技术国家重点实验室开放课题“Dissemination and removal of antibiotic pollution and resistance in aquatic ecosystems”,2017年5月-2018年5月,参与

18.山东省重点研发计划“口腔感染细菌类型及抗生素耐药性的快速检测技术”,2018年1月-2019年12月,参与

17.济南市文化产业发展专项资金“古籍字画霉变的防治技术”,2017年10月-2019年12月,技术负责人

16.国家重点研发计划“我国传统膳食结构的肠道微生态与健康效应相关性研究”,No. 2017YFD0400301,2017年7月-2020年12月,任务负责人

15.国家自然科学基金面上项目“里氏木霉中诱导纤维素酶表达的碳源信号转导途径及其机制”,No. 31770043,2018年1月-2021年12月,负责人

14.山东大学基本科研业务费交叉学科培育项目“呼吸道病原体的抗生素耐药性及其机制研究”,No. 2017JC028,2017年1月-2019年12月,参与

13. 2016年度生命科学学院创新基金“1型整合子中抗生素耐药基因的表达调控机制”,2016年11月-2016年12月,负责人

12.山东省重点研发计划“高效纤维素酶制剂的理性设计、制备与应用”,No. 2016GSF121040, 2016年9月-2017年12月,负责人

11.山东省科技重大专项(新兴产业)“先进酶制剂生产技术的研究及应用”,No. 2015ZDXX0403A01,2015年7月-2017年9月,参与

10.山东大学基本科研业务费交叉学科培育项目“污水处理系统中抗生素和抗性基因的污染特征与强化去除机制”,No. 2015JC025,2015年1月-2017年12月,交叉学科负责人

9.山东省自主创新及成果转化专项“新型木质纤维素酶系生产制备及产业化开发”,No. 2014CGZH1312,2014年10月-2016年12月,参与

8.横向项目“复合纤维素酶的菌种、生产工艺及薯渣制糖技术”,起止年月2014年4月至2016年6月,参与

7.国家科技支撑计划“秸秆等低值生物质生产高清洁汽柴油技术集成及产业化”课题中“基于木质纤维素的汽油/柴油有效组分的生物转化”,No. 2014BAD02B07,2014年1月-2016年12月,子课题负责人

6.教育部留学归国人员科研启动基金“热纤梭菌中氢酶的分布与性质研究”,2013年12月-2015年12月,负责人

5.国家能源应用技术研究及工程示范项目“生物质醇电联产关键技术和装备研发及应用示范”课题“万吨级纤维素乙醇生产关键技术研究及示范”,No. NY20130402,2013年1月-2015年12月,参与

4.国家自然科学基金青年基金“热纤梭菌中膜上Ech氢酶复合体的功能与性质研究”,No.31200051,2013年1月-2015年12月,负责人

3.国家863计划“新型木质纤维素酶系生产制备”,No.2012AA022302,起止年月2012年11月-2015年12月,参与

2.山东省自然科学基金青年基金“热纤梭菌中的Ech氢酶性质研究”,No.ZR2012CQ022,2012年7月-2015年7月,负责人

1.山东大学自主创新基金项目“热纤梭菌的产氢机制研究”,No. 2011HW008,2011年10月-2013年12月,负责人

代表性论文

78.Wang Y1, Su W1, Liu Z, Wang Y, Li L, Xu H,Wang M*, Shen W*. 2024. The microbiomic signature of haemorrhoids and comparison with associated microbiomes. Front Microbiol 15:1329976.

77.SongY, Huang R, Li L,Wang M, Wang S, Ferry JG*, Yan Z*. 2024. Response to comment on “Humic acid-dependent respiratory growth ofMethanosarcina acetivoransinvolves pyrroloquinoline quinone” by Yuanxu Song et al. ISME J 18(1):wrae019.

76.Yang J1, Li L1, Su W, Zhang S, Xu H,Wang M*, Shen W*. 2024. Microbiomic signatures of anal fistula and putative sources of microbes. Front Cell Infect Microbiol 14: 1332490.

75.Wang W, Ma Y, Ma Y, Zheng X, Yu J, Li L, Liu X, Gao H*, Xu H*,Wang M*. 2024. Significant impact of AcrB amino acid polymorphism at residue 716 on susceptibility to tigecycline and other antibiotics inKlebsiella pneumoniae. ACS Infect Dis 10(2): 541-552.

74.Wang C1, Zhang T1, Wang Y, Wang Y, Pan H, Dong X, Liu S, Cao M, Wang S,Wang M, Li Y, Zhang J*, Hu W*. 2024. Proguanil and chlorhexidine augment the antibacterial activities of clarithromycin and rifampicin againstAcinetobacter baumannii. Int J Antimicrob Agents 63(2):107065.

73.Xu Y1, Wang W1, Su W,Wang M, Xu H*, Zhang X*, Li L*. 2024. A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility inKlebsiella pneumoniae. Microbiol Spectr 12:e02030-23.

72.Jiang K1, Li W1, Tong M1, Xu J1, Chen Z1, Yang Y, Zang Y, Jiao X, Liu C, Lim B, Jiang X, Wang J, Wu D,Wang M, Liu S, Shao F, Gao X*. 2024.Bacteroides fragilisubiquitin homologue drives intraspecies bacterial competition in the gut microbiome. Nat Microbiol 9:70-84.

71. Wang M*. 2023. Editorial: Antimicrobial resistance dissemination and horizontal gene transfer. Front Cell Infect Microbiol 13:1240680.

70.Song Y1, Huang R1, Li L1, Du K, Zhu F, Song C, Yuan X,Wang M*, Wang S*, Ferry JG, Zhou S, Yan Z*. 2023. Humic acid-dependent respiratory growth ofMethanosarcina acetivoransinvolves pyrroloquinoline quinone. ISME J 17:2103–2111.

69.Zhang M, Ma Y, Xu H,Wang M, Li L*. 2023. Surfaces of gymnastic equipment as reservoirs of microbial pathogens with potential for transmission of bacterial infection and antimicrobial resistance. Front Microbiol 14:1192594.

68.LiuX, Dun M, Jian T, Sun Y,Wang M*, Zhang G*, Ling J*. 2023. Cordycepin andCordyceps militarisextracts ameliorates type 2 diabetes mellitus by modulating the gut microbiota and metabolites. Front Pharmcol 14:1134429.

67.Bie L1, Zhang M1, Wang J1, Fang M, Li L, Xu H,Wang M*. 2023. Comparative transcriptomic response analysis ofEscherichia coliK-12 MG1655 to nine representative classes of antibiotics. Microbiol Spectr 11: 00317-23.

66.Wei X1, Zhang J1, Wang B, Wang W, Sun Y, Li L, Xu H*,Wang M*. 2023. Spatially and temporally confined response of gastrointestinal antibiotic resistance gene levels to sulfadiazine and extracellular antibiotic resistance gene exposure in mice. Biology-Basel 12:210.

65.NieC, Geng X, Ouyang H, Wang L, Li Z,Wang M, Sun X, Wu Y, Qin Y, Xu Y, Tang X, Chen J*. 2023. Abundant bacteria and fungi attached to airborne particulates in vegetable plastic greenhouses. Sci Total Env 857: 159507.

64.Hu J, Li Z, Li L, Sun Y, Shi L, Li W, Zhang J, Wu Y, Xu H*,Wang M*. 2023. Detection of multidrug resistant pathogenic bacteria and novel complex class 1 integrons in campus atmospheric particulate matters. Sci Total Env 856(Part 1): 158976.

63.Li Z, Li M, Tong S, Fang M, Li W, Li L, Li X, Xu H*, Sun X*,Wang M*. 2022. Regionalization and shaping factors for microbiomes and core resistomes in atmospheric particulate matters. mSystems 7:00698-22.

62.Li W1, Yang Z1, Hu J, Wang B, Rong H, Li Z, Sun Y, Wang Y, Zhang X,Wang M*, Xu H*. 2022. Evaluation of culturable ‘last-resort’ antibiotic resistant pathogens in hospital wastewater and implications on the risks of nosocomial antimicrobial resistance prevalence. J Hazard Mat 438:129477.

61.Chen H, Zheng Y,Wang M, Wu Y, Yao M*. 2022. Gene-regulated release of distinctive volatile organic compounds (VOCs) from stressed living cells. Environ Sci Technol 56(13):9546-9555.

60.Li W, Hu J, Li L, Zhang M, Cui Q, Ma Y, Su H, Zhang X*, Xu H*,Wang M*. 2022. New mutations inclsleads to daptomycin resistance in a clinical vancomycin- and daptomycin-resistantEnterococcus faeciumstrain. Front Microbiol 13:896916.

59.Chen H, Wu X, Li L,Wang M, Song C, Wang S, Yan Z*. 2022.In vitroandin vivoroles of cyanobacterial carbonic anhydrase as a biomarker for monitoring antibiotics. J Hazard Mat Lett 3:100055.

58.Zhao R, Li Z, Sun Y, Ge W,Wang M, Liu H, Xun L, Xia Y*. 2022. Engineered Escherichia coli Nissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment. Gut Microb 14(1):e2070391.

57.Zhang X1, Li Z1, Hu J, Yan L, He Y, Li X,Wang M*, Sun X*, Xu H*. 2021. The biological and chemical contents of atmospheric particulate matter and implication of its role in the transmission of bacterial pathogenesis. Environ Microbiol 23(9):5481-5486.

56.李玲,王明钰*,徐海*.新型甲氧苄啶耐药二氢叶酸还原酶DfrB7的生化分析与宿主菌耐药机制研究[J].微生物学报, 2021, 61(12): 4097–4105.

55.Li Z, Shi L, Wang B, Wei X, Zhang J, Guo T, Kong J,Wang M*, Xu H*. 2021.In vitroassessment of antimicrobial resistance dissemination dynamics during multidrug-resistant-bacterium invasion events by using a continuous-culture device. Appl Environ Microbiol 87(6):e02659-20.

54.Li L, Zhang M, Wang W, Xia R, Ma Y, Wei X, Wang X, Sun X,Wang M*, Xu H*. 2021. Identification and characterization of two novel ISCR1-associated genesdfrA42anddfrA43encoding trimethoprim resistant dihydrofolate reductases. Antimicrob Agents Chemother 65(6):e02010-20.

53.李紫云1,贺艳艳1,王娟,王明钰,徐海*.肉食鸡中产超广谱β-内酰胺酶的耐药性大肠杆菌的检测和分析[J].微生物学报, 2021, 61(5): 1233–1245.

52. Wang M1, Wang W1, Niu Y, Liu T, Li L, Zhang M, Li Z, Su W, Liu F, Zhang X*, Xu H*. 2020. A clinical extensively-drug resistant (XDR)Escherichia coliand role of its β-lactamase genes. Front Microbiol 11:590357.

51.Yang Z, Cui Q, An R, Wang J, Song X, Shen Y,Wang M*, Xu H*. 2020. Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis (RAS)-affected patients. BMC Oral health 20:128.

50.Wei T, Gong J, Qu G,Wang M*, Xu H. 2019. Interactions betweenYersinia pestisV-antigen (LcrV) and human Toll-like Receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights. BMC Immunol 20:48.

49.Yu T, Kong J, Zhang L, Gu X,Wang M, Guo T*. 2019. New crosstalk between probioticsLactobacillus plantarumandBacillus subtilis. Sci Rep 9(1):13151. doi: 10.1038/s41598-019-49688-8.

48.Wang F1,Wang M1, Zhao Q, Niu K, Liu S, He D, Liu Y, Xu S, Fang X*. 2019. Exploring the relationship betweenClostridium thermocellumJN4 andThermoanaerobacterium thermosaccharolyticumGD17. Front Microbiol 10: 2035.

47.王明钰,张伟,郭卫华,刘振美,谭保才,泰山学堂助力山大生命拔尖学子小天下,创新人才培养模式培养拔尖创新人才-“生物学科拔尖学生培养试验计划”十年探索和实践,高等教育出版社, 2019, 87-100.

46. Li L, Yu T, Ma Y, Yang Z, Wang W, Song X, Shen Y, Guo T, Kong J,Wang M*, Xu H*. 2019. The genetic structures of an Extensively Drug Resistant (XDR)Klebsiella pneumoniaeand its plasmids. Front Cell Infect Microbiol 8: 446

45.Wang M1,Ma Y1, Li L, Wang B, Wei X, Zhang M, Wang J, Cui Q, Li Z*, Xu H*. 2019. The diversity of glycosylation of cellobiohydrolase I fromTrichoderma reeseidetermined with mass spectrometry. Biochem Biophys Res Commun508(3): 818-824.

44. Bie L, Fang M, Li Z,Wang M*, Xu H *. 2018. Identification and characterization of new resistance-conferring SGI1s (Salmonellagenomic island 1) inProteus mirabilis. Front Microbiol 9: 3172.

43. Wan X, Gao M, Wang Y, Xu H,Wang M, Wang X*. 2017. Formation, characteristics and microbial community of aerobic granular sludge in the presence of sulfadiazine at environmentally relevant concentrations. Bioresour Technol250:486-494.

42.Yuan S, Gao M, Ma H, Afzal MZ, Wang Y,Wang M, Xu H, Wang S, Wang X*. 2018. Qualitatively and quantitatively assessing the aggregation ability of sludge during aerobic granulation process combined XDLVO theory with physicochemical properties. J Environ Sci 67: 154-160. doi: 10.1016/j.jes.2017.08.015.

41. Yuan S, Gao M, Zhu F, Afzal MZ, Wang Y, Xu H,Wang M, Wang S, Wang X*. 2017. Disintegration of aerobic granules during prolonged operation. Environ Sci: Water Res Technol3:757.

40. Wang M1, Shen W1, Yan L, Wang X, Xu H*. 2017. Stepwise impact of urban wastewater treatment on bacterial community structure, content of antibiotics, and prevalence of antimicrobial resistance. Environ Pollut 231(P2):1578-1585.

39.李紫云,王明钰,徐海*.细菌II型、III型整合子在耐药性传播中的作用[J].中国抗生素杂志, 2018,43(2):156-162.

38.崔庆宇,王明钰,徐海*.lux荧光报告系统的研究进展[J].中国生物工程杂志, 2017,37(8):66-71.

37.Wang M, Zhang M, Li L, Dong Y, Jiang Y, Liu K, Zhang R, Jiang B, Niu K, Fang X*. 2017. Role ofTrichoderma reeseimitogen-activated protein kinases (MAPKs) in cellulase formation. Biotechnol Biofuels10:99.

36.Guo N, Wang Y*, Yan L, Wang X,Wang M, Xu H, Wang S*. 2017. Effect of bio-electrochemical system on the fate and proliferation of antibiotic resistance genes during the treatment of chloramphenicol wastewater. Water Res117:95-101.

35.马亚楠,王明钰*,徐海.纤维素酶糖基化的研究进展[J].微生物学报, 2017,57(8):1-8.

34.Bie L, Wu H, Wang X,Wang M*, Xu H*. 2017. Identification and Characterization of new SXT/R391 family integrative and conjugative elements (ICEs) inProteus mirabilisisolates from broiler carcasses. Int J Antimicrob Agents50(2):242-246

33.Yan Z,Wang M, Ferry JG*. 2016. A Ferredoxin- and F420H2-dependent, electron-bifurcating, heterodisulfide reductase with homologs in the domainsBacteriaandArchaea. mBio8:e02285-16.

32.Yan L, Liu D, Wang X, Wang Y,Wang M*, Xu H*. 2017. Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China. Sci Rep7:40610.

31. Wang M*, Hou J*. 2017. Biorefinery of lignocellulosics for biofuels and biochemicals, p 143-191.InLau PCK (ed), Quality living through chemurgy and green chemistry, Springer-Verlag GamH, Germany.

30.Wu H,Wang M,Liu Y, Wang X, Wang Y, Lu J, Xu H*. 2016. Data on the phylogenetic typing, integron gene cassette array analysis, multi-drug resistance analysis and correlation between antimicrobial resistance determinants inKlebsiellastrains. Data Brief8:1289-1294.

29. Wang M, Zhao Q, Li L, Niu K, Li Y, Wang F, Jiang B, Liu K, Jiang Y, Fang X*. 2016. Contributing factors in the improvements of cellulosic H2production inClostridium thermocellum/Thermoanaerobacteriumco-cultures. Appl Microbiol Biotechnol100(19):8607-8620.

28.Liu R, Wang X*, Zhang Y,Wang M, Gao M, Wang S. 2016. Optimization of operation conditions for the mitigation of nitrous oxide (N2O) emissions from aerobic nitrifying granular sludge system. Environ Sci Pollut Res23(10):9518-9528.

27.沈伟涛,王明钰,王允坤,王新华,徐海*.抗生素含量测定方法的分析综述[J].中国生物工程杂志, 2016, 36(6): 119-126.

26.Wu H,Wang M, Liu Y, Wang X, Wang Y, Lu J, Xu H*. 2016. Characterization of antimicrobial resistance inKlebsiellaspecies isolated from chicken broilers. Int J Food Microbiol232:95-102.

25.Gao M, Yang S,Wang M, Wang X*. 2016. Nitrous oxide emissions from an aerobic granular sludge system treating low-strength ammonium wastewater. J Biosci Bioeng doi: 10.1016/j.jbiosc.2016.04.004.

24.Jiang B, Zhang R, Feng D, Wang F, Liu K, Jiang Y, Niu K, Yuan Q,Wang M,Wang H, Zhang Y, Fang X*. 2016. A Tet-on and Cre-loxP based genetic engineering system for convenient recycling of selection markers inPenicillium oxalicum. Front Microbiol7:486.

23.Wang F, Jiang Y, Guo W, Niu K, Zhang R, Hou S,Wang M, Yi Y, Zhu C, Jia C, Fang X*. 2016. An environmentally friendly and productive process for bioethanol production from potato waste. Biotechnol Biofuels9:50.

22.Liu K, Dong Y, Wang F, Jiang B,Wang M,Fang X*. 2016. Regulation of cellulase expression, sporulation and morphogenesis by velvet family proteins inTrichoderma reesei. Appl Microbiol Technol100(2):769-779.

21. Wang M,Han L, Liu S, Zhao X, Yang J, Loh SK, Sun X, Zhang C, Fang X*. 2015. A Weibull statistics-based lignocellulose saccharification model and a built-in parameter accurately predict lignocellulose hydrolysis performance. Biotechnol J10(9):1424-1433.

20.Wang F, Liu K, Han L, Jiang B,Wang M, Fang X*. 2015. Function of a p24 heterodimer in morphogenesis and protein transport inPenicillium oxalicum. Sci Rep5:11875.

19.Wang M, Yang H, Zhang M, Liu K, Wang H, Luo Y, Fang X*. 2015. Functional analysis ofTrichoderma reeseiCKIIα2, a catalytic subunit of casein kinase II. Appl Microbiol Biotechnol99(14):5929-5938.

18. Wang M,Dong Y, Zhao Q, Wang F, Liu K, Jiang B, Fang X*. 2014. Identification of the role of a MAP kinase Tmk2 inHypocrea jecorina(Trichoderma reesei). Sci Rep 4:6732.

17.张杰,王明钰,张晓东,方诩*,李红震.以木质纤维素原料生产生物丁醇的研究进展[J].生物产业技术, 2014, 2014(7月): 59-64.

16.Suharti S,Wang M, de Vries S, Ferry JG*. 2014. Characterization of the RnfB and RnfG Subunits of the Rnf Complex from the ArchaeonMethanosarcina acetivorans. PLoS ONE9(5):e97966.

15.王方忠,蒋艺,刘奎美,姜宝杰,王明钰,方诩*.丝状真菌中纤维素酶与半纤维素酶的合成调控[J].生物加工过程, 2014, 12(1): 72-79.

14.王明钰,沈煜,徐孝刚,邵明,魏天迪,方诩*.山东大学生物类拔尖人才培养模式的探索[J].高校生物学教学研究(电子版), 2013, 3(4): 3-6.

13.Wang F, Liang Y,Wang M, Yang H, Liu K, Zhao Q, Fang X*. 2013. Functional diversity of the p24γ homologue Erp reveals physiological differences between two filamentous fungi. Fungal Genet Biol61:15-22.

12.自振滔,石文昊,李钰茜,翟贞文,韩丽娟,王明钰*,方诩*.利用等离子诱变技术改造纤维素酶生产丝状真菌工业菌株[J].中国酿造, 2013, 32(S1): 5-8.

11.Wang M,He D, Liang Y, Liu K, Jiang B, Wang F, Hou S, Fang X*. 2013. Factors involved in the response to improvement of agitation during cellulase production fromPenicillium decumbensJUA10-1. J Ind Microbiol Biotechnol40(9):1077-1082.

10. Wang M,Zhao Q, Yang J, Jiang B, Wang F, Liu K, Fang X*. 2013. A mitogen-activated protein kinase Tmk3 participates in high osmolarity resistance, cell wall integrity maintenance and cellulase production regulation inTrichoderma reesei. PLoS ONE8(8): e72189.

9. Wang M,Mu Z, Wang J, Hou S, Han L, Dong Y, Xiao L, Xia R, Fang X*. 2013. The identification of and relief from Fe3+inhibition for both cellulose and cellulase in cellulose saccharification catalyzed by cellulases fromPenicillium decumbens. Bioresour Technol133:507-512.

8. Wang M, Liu K, Dai L, Zhang J, Fang X*. 2013. The structural and biochemical basis for cellulose biodegradation. J Chem Technol Biot88(4):491-500.

7.Zhang J,Wang M, Gao M, Fang X*, Yano S, Qin S, Xia R. 2013. Efficient acetone-butanol-ethanol production from corncob with a new pretreatment technology - wet disk milling. Bioenerg Res6(1):35-43.

6.周广麒,李晶晶,李忠海,吕晶,王明钰,曲音波,方诩*.斜卧青霉转录调控因子BglR的缺失对纤维素酶生产的影响[J].微生物学通报, 2012, 39(10): 1379-1387.

5.周广麒,吕晶,李忠海,李晶晶,王明钰,曲音波,肖林,覃树林,赵海涛,夏蕊蕊,方诩*.斜卧青霉去泛素化蛋白酶CREB的缺失提高纤维素酶的生产[J].生物工程学报, 2012, 28(8): 959-972.

4.王涫,王明钰,穆子铭,侯少莉,伏小平,方诩*.里氏木霉纤维素酶生产工艺的优化[J].黑龙江农业科学, 2012, 2012(5): 108-111.

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所获专利

7.王明钰,陶继方,庞子瑞,史路路,谢晓鸿,谢世灵,胡玮,谷立川,徐海,李玲.一种甩动式微流控芯片、核酸检测设备及方法:中国,202410730678.9[P].

6.王明钰,于江浩,徐海,李玲.一种利用NHS活化的琼脂糖凝胶的核酸富集方法:中国,202410376978.1[P].

5.王明钰,于江浩,徐海,李玲. NHS活化的羧基化琼脂糖及其制备和在核酸去除中的应用:中国,202410376971.X[P]

4.王明钰,徐海,房萌.一种能在水环境中去除抗生素耐药基因的人工合成蛋白:中国,202110685532.3 [P].

3.王明钰,徐海.一种利用生物发光报告系统鉴定抗生素种类的方法:中国,201910526550.X [P].

2.王明钰,徐海.一种利用生物发光报告系统判定抗生素作用机制的方法:中国,201910526571.1[P].

1.王明钰, 赵秋爽,方诩, 候少丽. 一种真菌纤维素酶酶系组成/特性调控基因及其应用: 中国,201310142896.2[P].