代表性论文:
1.Glassey, E.#;Zhang, Z.#;King, A. M.; Niquille, D. L.; Voigt, C. A.Computational design of enzyme modified peptides.Nat. Chem.2024(accepted).
2.King, A. M.#;Zhang, Z.#;Glassey, E.;Siuti P.; Clardy J.;Voigt, C. A. Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra.Nat Microbiol.2023,8, 2420–2434.
3.Zhang, Z.; van der Donk, W. A.Nonribosomal Peptide Extension by a Peptide Amino-Acyl tRNA Ligase.J. Am. Chem. Soc.2019, 141, 19625–19633.
4.Zhang, Z.; Mahanta, N.; Hudson, G. A.; Mitchell, D. A.; van der Donk, W. A., Mechanism of a Class C RadicalS-Adenosyl-L-methionine Thiazole Methyl Transferase.J. Am. Chem. Soc.2017,139, 18623-18631.
5.Zhang, Z.; Hudson, G. A.; Mahanta, N.; Tietz, J. I.; van der Donk, W. A.; Mitchell, D. A., Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin.J. Am. Chem. Soc.2016,138, 15511-15514.
6.Hudson, G. A.#;Zhang, Z.#; Tietz, J. I.; Mitchell, D. A.; van der Donk, W. A., In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin.J. Am. Chem. Soc.2015,137, 16012-16015.
7.Ting, C. P.; Funk, M. A.; Halaby, S. L.;Zhang, Z.; Gonen, T.; van der Donk, W. A. Use of a scaffold peptide in the biosynthesis of amino acid–derived natural products.Science2019,365, 280-284.
8.King, A. M.; Anderson, D. A.; Glassey, E.; Segall-Shapiro, T. H.;Zhang, Z.; Niquille, D. L.; Embree, A. C.; Pratt, K.; Williams, T. L.; Gordon, D. B.; Voigt, C. A. Selection for constrained peptides that bind to a single target protein.Nat. Commun.2021, 12 (1), 1-12
9.Cogan, D. P.; Hudson, G. A.;Zhang, Z.; Pogorelov, T. V.; van der Donk, W. A.; Mitchell, D. A.; Nair, S. K., Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.Proc. Natl. Acad. Sci. USA.2017,114, 12928-12933.
10.Mahanta, N.;Zhang, Z.; Hudson, G. A.; van der Donk, W. A.; Mitchell, D. A., Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine ThiazoleC-Methyltransferase in Thiomuracin Biosynthesis.J. Am. Chem. Soc.2017,139, 4310-4313.
11.Glassey, E;King, A. M.; Anderson, D. A.;Zhang, Z.; Voigt, C. A.Functional expression of diverse post-translational peptide-modifying enzymes inEscherichia coliunder uniform expression and purification conditions.PLoS One. 2022, 17(9): e0266488.
12.Yuan, L.;Zhang, Z.; Xu, X.; Zhou, X. Chemical labeling of 5-iodo-2’-deoxyuridine with 4-ethynyl-N-ethyl-1,8-naphthalimide using copper-free Sonogashira cross-coupling in aqueous medium.Synth. Commun.2014, 44, 1007-1011
13.Tian, T.; Xiao, H.;Zhang, Z.; Long, Y.; Peng, S.; Wang, S.; Zhou, X.; Liu, S.; Zhou, X., Sensitive and convenient detection of microRNAs based on cascade amplification by catalytic DNAzymes.Chem. Eur. J.2013,19, 92-95.
14.Yuan, L.; Tian, T.; Chen, Y.; Yan, S.; Xing, X.;Zhang, Z.; Zhai, Q.; Xu, L.; Wang, S.; Weng, X.; Yuan, B.; Feng, Y.; Zhou, X., Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy.Sci. Rep.2013,3, 1811.