教授 & 研究员

赵建

教授
博士/硕士生导师
0532-58632409
个人简介 科研项目 学术论文 其他介绍

教育和工作经历:

1999年7月毕业于天津科技大学,获工学博士学位,同年进入山东大学微生物技术国家重点实验室生物学博士后流动站开展研究,2001年8月出站留校工作。2001年9月评聘副教授,硕士生导师;2005年9月破格晋升教授,博士生导师。2006.9-2007.9加拿大康考迪亚大学生物系访问学者,2014.9-2015.5美国威斯康辛大学麦迪逊校区农业与生命科学学院高级研究学者。


学术兼职:

中国食品学会酶制剂分会常务理事

中国生物发酵产业协会理事

中国造纸学会纳米纤维素与材料专业委员会委员

工业酶产业技术创新战略联盟学术委员会委员

黑龙江省寒区环境微生物与农业废弃物资源化利用重点实验室学术委员会委员

国际期刊Paper and Biomaterials, International Journal of Molecular Sciences等的编委


科研方向:

1.木质纤维素降解酶的研发、生产及应用

(1)纤维素酶、半纤维素酶、木质素降解酶如漆酶等各类木质纤维素降解酶类的高产菌株选育及其工程改造;

(2)酶分子工程改造、酶的发酵生产及应用(从实验室、中试到工业化生产规模)

2.植物木质纤维素生物质的生物降解转化和高值化利用

(1)木质纤维素的组分分离技术

(2)生物质酶法降解生产葡萄糖、木糖等可发酵糖技术,建立非粮生物质原料“糖平台”。

(3)半纤维素的降解和转化技术,其中利用玉米芯、阔叶木等原料生产低聚木糖、木糖醇等已经实现工业化生产。

(4)木质素高值化利用技术,如纳米木质素、高性能材料、表面活性剂等

(5)纳米纤维素的酶法制备及其应用

(6)木质纤维素的全组分综合利用技术及其工艺整合,实现生物质炼制(Biomass biorefinery)

3.谷物种皮类生物质降解酶的研制、生产和应用技术

谷物类农产品(如玉米、大豆等)加工副产物—谷物种皮(玉米皮、大豆皮等)高效降解酶系的研制、规模化生产及其应用技术。例如:研发的玉米皮降解酶系可广泛应用于燃料乙醇、柠檬酸等以玉米为原料的生产过程,增加产品收率。

(2)谷物种皮类生物质的生物转化和高值化应用技术。

4.碱性/耐碱性酶类的研发及其应用

适合造纸、纺织、印染、食品等工业不同工艺要求的碱性/耐碱性酶制剂的研发和生产,例如碱性/耐碱性纤维素酶、碱性漆酶、碱性果胶酶等的高产菌株的工程改造和选育、工业用复合酶系研发、生产及其应用等。其中造纸工业用酶和碱性果胶酶已经成功应用于工业化生产。

主持课题

先后主持包括6项国家自然科学基金,国家重点研发计划、国家863计划、国家973计划、国际合作项目、省部级重大重点项目等各类纵向课题20多项,以及与中粮、中石油、国投等多家企业合作的多项横向课题。部分项目如下:

国家重点研发项目:纳米纤维素的酶法制备体系构建及分子量调控(2022YFC3401704), 2022-2027

国家重点研发项目:木质纤维素聚糖酶法降解生产可发酵糖关键技术(2023YFB4203502),2023-2027

国家自然科学基金面上项目:纤维素酶在木质素上的吸附规律和机制及弱木质素吸附性酶的构建, 2019-2022

山东省自然科学基金(重大基础类):木质纤维素类生物质高效降解转化的关键机理研究,2019-2024

山东省重点研发计划(重大科技创新工程)项目:杜仲木质纤维素高值化利用关键技术,2019-2021

中石油合作横向课题:高效纤维素酶菌株构建及发酵产酶技术研究,2018-2023

中石油合作横向课题:玉米纤维产乙醇关键技术研究,2022-2026

山东省重点研发计划:甜高粱秆固体发酵残渣生物转化生产液体燃料乙醇及其综合利用研究,2019-2021

国家自然科学基金面上项目:木质纤维素材料预处理过程中木质素结构和性质的变化及其对纤维素酶吸附的影响及机制,2013-2016

山东省自主创新重大专项:造纸行业生物质主流组分分离与高值利用关键技术研究与示范,2014-2017

国家973计划(2011CB707401):生物质预处理及对纤维素酶解与转化的影响机制,2011-2015

国家863计划(2012AA022203B):造纸用木质素酶和纤维素酶的分子改造及应用,2012-2015

研究成果

以第一或通讯作者在国内外发表研究论文200余篇,其中SCI、EI等收录超百篇;已授权国家发明专利11件;参与编写著作4部,译著1部。

近年来发表的部分文章:

2024年

1 Xianqin LU, Xuezhi Li, Jian Zhao*,Improving enzymatic efficiency of β-glucosidases in cellulase system by altering its binding behavior to the insoluble substrate during bioconversion of lignocellulose. Bioresource Technology, 2024,391, part A:129974

2 Qinqin Zhao1, Zheng Zhang1, Zhihao Liu, Huiqi Liang, Liwei Gao, Jian Zhao*, Guodong Liu*, Yinbo Qu. A closed-loop strategy for on-site production of saccharolytic enzymes for lignocellulose biorefinery using internal lignocellulosic hydrolysates, Chemical Engineering Journal, 2024, 480:148272

3 Wan Sun, Zheng Zhang, Xuezhi Li*, Xianqin Lu, Guodong Liu, Yuqi Qin, Jian Zhao*, Yinbo Qu. Production of single cell protein from brewer’s spent grain through enzymatic saccharification and fermentation enhanced by ammoniation pretreatment, Bioresource Technology, 2024, 394:130242

4 Yuqing Zhang, Huiwen Li, Qi Xin, Jian Zhao, Tao Xia,*, Xianqin Lu*,The role of glycosylation in non-productive adsorption of cellulase to lignin isolated from pretreated corn stover,International Journal of Biological Macromolecules,2024,266(Part 1): 130836

5 Qi Xin, Huiwen Li. Wan Sun, Xuezhi Li, Xianqin Lu*, Jian Zhao*. Lignin-xylan nanospheres prepared by green and quick method from lignocellulose and used as additive in PVA films, International Journal of Biological Macromolecules, 2024, 264:129763

6 Zheng Zhang, Jing Xing, Xuezhi Li, Xianqin Lu, Guodong Liu, Yinbo Qu*, Jian Zhao*. Research progress on cellulases from filamentous fungi and its production, International Journal of Biological Macromolecules, 2024, 277:134539

7 Huiwen Li, Qi Xin, Xuezhi Li, Xianqin Lu*, Jian Zhao*. Microwave-associated ZnCl2 pretreatment followed by enzymatic hydrolysis for high-efficiency production of nanocellulose from Eucalyptus Dissolving Pulp, Chemical Engineering Journal, 2024, 500: 157280

8 Jiamin Huang, Xuezhi Li, Jian Zhao *, Yinbo Qu. Fed-batch strategy achieves the production of high concentration fermentable sugar solution and cellulosic ethanol from pretreated corn stover and corn cob.International Journal of Molecular Sciences, 2024, 25(22), 12306

2023年

1 Tiantian Yang, Xuezhi Li, Yingjie Guo, Jian Zhao*, Yinbo Qu. Preparation of nanocellulose crystal from bleached pulp with an engineering cellulase and co-production of ethanol, Carbohydrate Polymers, 2023, 301(Part A): 120291

2 Guo Yingjie, Zheng Zhang, Jinze Dou, Guodong Liu, Xuezhi Li*, Jian Zhao*. Structural characterization of corn fiber hemicelluloses extracted by organic solvent and screening of degradation enzymes, Carbohydrate Polymers, 2023,313:120820

3 Jincheng Wang, Zhaoxi Liu, Xuezhi Li, Guodong Liu, Jian Zhao*. Elucidating structure of pectin in ramie fiber to customize enzyme cocktail for high-efficiency enzymatic degumming, Carbohydrate Polymers,2023, 314: 120954

4 Jinze Dou*, Jincheng Wang, Sami Hietala, Dmitry V. Evtuguin, Tapani Vuorinen* and Jian Zhao. Structural features of lignin–hemicellulose–pectin (LHP) orchestrate a tailored enzyme cocktail for potential applications in bark biorefineries, Green Chemistry, 2023, 25, 5661–5678

5 Pratima Waghmare, Nuo Xu, Pankajkumar Waghmare, Guodong Liu, Yinbo Qu, Xuezhi Li, Jian Zhao*. Production and Characterization of Cellulose Nanocrystals from Eucalyptus Dissolving Pulp using Endoglucanases fromMyceliophthora thermophila,International Journal of Molecular Sciences, 2023, 24, 10676

6 Tiantian Yang, Xuezhi Li*, Nuo Xu, Yingjie Guo, Guodong Liu and Jian Zhao*. Preparation of cellulose nanocrystals from commercial dissolving pulp using an engineered cellulase system,Bioresources and Bioprocessing, 2023, 10: 42

7 Qinqin Zhao, Zezheng Yang, Ziyang Xiao, Zheng Zhang, Jing Xing, Huiqi Liang, Liwei Gao, Jian Zhao, Yinbo Qu, Guodong Liu, Structure-guided engineering of transcriptional activator XYR1 for inducer-free production of lignocellulolytic enzymes inTrichoderma reesei. Synthetic and Systems Biotechnology, 2023, 8:732-740

2022年

1 Xiujun Zhang, Yueyan Hu, Guodong Liu, Meng Liu, Zhonghai Li, Jian Zhao, Xin Song, Yaohua Zhong, Yinbo Qu, Lushan Wang, Yuqi Qin.The complex Tup1‐Cyc8 bridges transcription factor ClrB and putative histone methyltransferase LaeA to activate the expression of cellulolytic genes,Molecular Microbiology,2022;00:1–21.

2 Dou Jinze*; Wang, Jincheng; Zhao Jian*; Vuorinen Tapani. Tailor-made Enzyme Consortium Segregating Sclerenchyma Fibre Bundles from Willow Bark.Green Chem. 2022,24(6):2576-25872022-3-21

3 Yingjie Guo, Jiamin Huang, Nuo Xu, Hexue Jia, Xuezhi Li*, Jian Zhao* and Yinbo Qu. A detoxification-free process for enhanced ethanol production from corn fiber under semi-simultaneous saccharification and fermentation. Frontiers in Microbiology, 2022, 13, 861918

4 Hexue Jia; Xiaoting Feng; Jiamin Huang; Yingjie Guo; Daolei Zhang; Xuezhi Li*; Jian Zhao*.Recombinant Family 1 Carbohydrate-Binding Modules Derived From Fungal Cellulase Enhance Enzymatic Degradation of Lignocellulose as Novel Effective Accessory Protein, Front. Microbiol. 2022,13: 876466

5 Yingjie Guo, Guodong Liu, Yanchun Ning, Xuezhi Li1*, Shiyang Hu, Jian Zhao*, Yinbo Qu. Production of cellulosic ethanol and value-added products from corn fiber. Bioresources and Bioprocessing, 2022, 9:81

6 Wan Sun, Xuezhi Li, Jian Zhao*, Yuqi Qin*. Pretreatment Strategies to Enhance Enzymatic Hydrolysis and Cellulosic Ethanol Production for Biorefinery of Corn Stover.International Journal of Molecular Sciences,2022,23(21), 13163.

2021年

1 Yueyan Hu, Kaili Zhao, Yinbo Qu, Xin Song, Jian Zhao, Yuqi Qin.Penicillium oxalicumS-adenosylmethionine synthetase is essential for the viability of fungal cells and the expression of genes encoding cellulolytic enzymes,Fungal Biology,

2 Haiyan Chen, Xuezhi Li, Shaoyang Yu, Yuqi Qin*, Yinbo Qu, Jian Zhao,*.Potassium Permanganate Assisted Organosolv Pretreatment Enhances Enzymatic Hydrolysis of Corn Stover,GCB-Bioenergy,2021, 13:665-678.

3 Hexue Jia; Wan Sun; Xuezhi Li*; Jian Zhao*.Cellulose induced protein 1 (Cip1) fromTrichoderma reeseienhances the enzymatic hydrolysis of pretreated lignocellulose, Microbial Cell Factories, 2021, 20(1):136

4 叶延欣,宁艳春,李雪芝*,岳 军,刘国栋,赵建*. β-木糖苷酶及其在纤维素乙醇生产中的应用研究进展,生命科学,2021,33(6):773-780

5 Liwei Gao, Xin He, Yingjie Guo, Zehua Wu, Jian Zhao, Guodong Liu*, Yinbo Qu. Combinatorial Engineering of Transcriptional Activators inPenicillium oxalicumfor Improved Production of Corn-Fiber-Degrading Enzymes, J. Agric. Food Chem. 2021, 69(8):2539–2548

6 Xiaoting Feng, Yini Yao, Nuo Xu, Hexue Jia, Xuezhi Li*, Jian Zhao*, Shicheng Chen, and Yinbo Qu. Pretreatment Affects Profits From Xylanase During Enzymatic Saccharification of Corn Stover Through Changing the Interaction Between Lignin and Xylanase Protein,Frontiers in Microbiology, 2021, vol 12, Article 754593

2020年

1 Daolei Zhang, Xuezhi Li*, Jian Zhao*. Fusarium concolor X4 pretreatment suppresses light-induced yellowing of high-yield pulp. BioMed Research International, 2020, Article 9497215.

2 Tiantian Yang, Yingjie Guo, Na Gao, Xuezhi Li, Jian Zhao*. Modification of a cellulase system by engineeringPenicillium oxalicumto produce cellulose nanocrystal, Carbohydrate Polymers, 2020, Vol 234, 115862

3 Tiantian Yang, Xuezhi Li, Yingjie Guo, Shengjuan Peng, Guodong Liu, Jian Zhao*. Effect of endoglucanases from different glycoside hydrolase families on enzymatic preparation of cellulose nanocrystal. Industrial Crops and Products, 155(2020):112755

4 Xiujun Zhang, Mengxue Li, Yingying Zhu, Ling Yang, Yanan Li, Jingyao Qu, Lushan Wang, Jian Zhao, Yinbo Qu, Yuqi Qin*.Penicillium oxalicumputative methyltransferase Mtr23B has similarities and differences with LaeA in regulating conidium development and glycoside hydrolase gene expression, Fungal Genetics and Biology, 143(2020):103445

5 Li Xuezhi, Zhao Jian*, Biotreatment of wastewater from soda-pretreatment process of corn stover using white-rot fungus Z-6, Paper and Biomaterials, 2020, 5(4):8-17

2019年

1 Fenfen Guo,Xuezhi Li*, Jian Zhao*, Guanxi Li, Peike Gao, Xiaolong Han Optimizing Culture Conditions by Statistical Approach to Enhance Production of Pectinase fromBacillussp. Y1. BioMed Research International,2019, Article ID 8146948

2 Yanan Li; Yueyan Hu; Zhu Zhu; Kaili Zhao; Guodong Liu; Lushan Wang; Yinbo Qu; Jian Zhao; Yuqi Qin*. Normal transcription of cellulolytic enzyme genes relies on the balance between the methylation of H3K36 and H3K4 inPenicillium oxalicum. Biotechnology for Biofuels, 2019, 12:198

3 Ya'nan Li, Yueyan Hu, Kaili Zhao, Yunjun Pan, Yinbo Qu, Jian Zhao, Yuqi Qin*. The indispensable role of histone methyltransferase PoDot1 in extracellular glycoside hydrolase biosynthesis ofPenicillium oxalicum, Frontiers in Microbiology, 2019, 10: 2566

2018年

1 Xianqin Lu, Xiaoting Feng, Xuezhi Li, Jian Zhao*. Binding and hydrolysis properties of engineered cellobiohydrolases and endoglucanases. Bioresource Technology, 2018. 267:235-241

2 Xianqin Lu, Xiaoting Feng, Xuezhi Li, Jian Zhao*. The adsorption properties of endoglucanase to lignin and their impact on hydrolysis, Bioresource Technology, 2018. 267:110-116

3 Can Wang, Xianqin Lu, Jia Gao, Xuezhi Li, Jian Zhao*. Xylo-oligosaccharides Inhibit Enzymatic Hydrolysis by Influencing Enzymatic Activity of Cellulase fromPenicillium oxalicum, Energy & Fuels, 2018, 32: 9427-9437

4 Jian Du, Wenxia Song, Xiu Zhang, Jian Zhao, Guodong Liu, Yinbo Qu*, Differential Reinforcement of enzymatic hydrolysis by adding chemicals and accessory proteins to high solid loading substrates with different pretreatments. Bioprocess and Biosystems Engineering 2018, 41:1153-1163

5 Jian Du, Xiu Zhang, Xuezhi Li, Jian Zhao, Guodong Liu⁎, Baoyu Gao, Yinbo Qu. The cellulose binding region inTrichoderma reeseicellobiohydrolase I has a higher capacity in improving crystalline cellulose degradation than that ofPenicillium oxalicum, Bioresource Technology, 2018. 266:19-25

2017年

1 Jian Dua, Yuan Cao, Guodong Liu, Jian Zhao, Xuezhi Li, Yinbo Qu*. Identifying and overcoming the effect of mass transfer limitation on decreased yield in enzymatic hydrolysis of lignocellulose at high solid concentrations. Bioresource Technology, 2017,229:88-95

2Meimei Wang,·Yanxin Ye,·Xuezhi Li,·Hao Chen,·Jian Zhao*,Utility of co-expressed alkali-tolerant endoglucanase and xylanase in ameliorating wheat straw chemical pulp properties, Cellulose, 2017,24(5), 2299-2311

3 Yanxin Ye,Xuezhi Li, Yuan Cao, Jian Du, Shicheng Chen, Jian Zhao*. A β-xylosidase hyper-productionPenicillium oxalicummutant enhanced ethanol production from alkali-pretreated corn stover. Bioresource Technology, 2017,245:734-742

4 Yanxin Ye, Xuezhi Li, Jian Zhao*. Production and Characteristics of a Novel Xylose- and Alkali-tolerant GH 43 β-xylosidase fromPenicillium oxalicumfor Promoting Hemicellulose Degradation. Scientific Reports, 2017, 7:11600

5 Xianqin Lu, Can Wang, Xuezhi Li, Jian Zhao*. Temperature and pH influence adsorption of cellobiohydrolase onto lignin by changing the protein properties. Bioresource Technology, 2017,245:819-825

6 Meimei Wang, Jian Du, Daolei Zhang, Xuezhi Li, Jian Zhao*. Modification of Different Pulps by Homologous Overexpression Alkali-Tolerant Endoglucanase inBacillus subtilisY106, Scientific Reports, 2017, 7:3321

7 Xianqin Lu, Can Wang, Xuezhi Li, Jian Zhao*, Xuebing Zhao. Studying nonproductive adsorption ability and binding approach of cellobiohydrolase to lignin during bioconversion of lignocellulose, Energy & Fuels, 2017, 31 (12): 14393–14400, 2017-10-19

荣誉奖励:

2024年辽宁省自然科学二等奖

2014年山东省科技进步二等奖

2014年山东省优秀硕士学位论文指导奖

2014年山东大学优秀硕士学位论文指导奖

2004年山东省科学技术发明二等奖

2004年山东高等学校优秀科研成果二等奖(自然科学类)


指导的多名博士生和硕士生连续多年获得国家奖学金、优秀毕业生等。