教育背景:
2009/09-2015/06 中国科学技术大学 生物化学与分子生物学 博士
2005/09-2009/07 安徽大学 生物技术 学士
工作经历:
2021/08-今 山东大学微生物技术研究院 副研究员
2017/08-2021/07 中国科学院青岛生物能源与过程研究所 博士后
2015/06-2017/07 中国科学技术大学 博士后研究员
研究方向:
细菌基因编辑方法
蛋白质工程与定向进化
大肠杆菌及耐热酵母的代谢工程
多组学的生物信息学分析
主要项目:
更通用的细菌基因编辑方法研究,山东省自然学基金青年基金(ZR2022QC123),15万元,2023.01.01- 2025.12.30,主持。
生物基橡胶绿色制造关键技术-生物基单体制备关键技术-子任务3,国家重点研发计划-绿色生物制造专项(2022YFC2104701),50万元,2022.11-2026.10,骨干(主持子任务3)。
马克斯克鲁维酵母高效生物合3-羟基丙酸及关键酶的迭代定向进化研究,广东省基础与应用基础研究基金-区域联合基金(粤深)-青年基金(2022A1515110047),10万元,2022.10-2025.09,主持。
代表性论文:
Zhang, Jia#; Su, Xiaolu#; Wang, Yefei; Wang, Xiaohang; Zhou, Shiqi; Jia, Hui; Jing, Xiaoyan; Gong, Yanhai;Wang, Jichao*; Xu, Jian*.Improved single-cell genome amplification by a high-efficiency phi29 DNA polymerase.Frontiers in Bioengineering and Biotechnology,2023,11:1233856. (among the topmost viewed and downloaded this year's articles)
Zhang, Jia; Xu, Teng; Wang, Xiaohang; Jing, Xiaoyan; Zhang, Jia; Hong, Jiong; Xu, Jian;Wang, Jichao*. Lignocellulosic xylitol production from corncob waste by engineeredKluyveromyces marxianus.Frontiers in Bioengineering and Biotechnology,2022, 10:1029203.
Zhao, Zhe; Xu, Ying; Jiang, Bo; Qi, Qingsheng; Tang, Ya-Jie; Xian, Mo;Wang, Jichao*; Zhao, Guang*. Systematic Identification of CpxRA-Regulated Genes and Their Roles in Escherichia coli Stress Response.mSystems, 2022, e00419-22.
Hu, Shenglin; Wang, Zhefan; Wang, Dongmei;Wang, Jichao*; Hong, Jiong*. The development of a heterologous gene expression system in thermophilic fungusThermoascus aurantiacus.3 Biotech, 2021, 11(9): 1-15.
Li, Shihua#; Yu, Kai#; Wu, Guandi#; Zhang, Qingfeng; Wang, Panqin; Zheng, Jian; Liu, Ze-Xian;Wang, Jichao*; Gao, Xinjiao*; Cheng, Han*. pCysMod: Prediction of Multiple Cysteine Modifications Based on Deep Learning Framework.Frontiers in Cell and Developmental Biology, 2021, 9:617366..
Wang, Jichao#; Sui, Xinyue#; Ding, Yamei; Fu, Yingxin; Feng, Xinjun; Liu, Min; Zhang, Youming; Xian, Mo*; Zhao, Guang*. A fast and robust iterative genome-editing method based on a Rock-Paper-Scissors strategy.Nucleic Acids Research, 2021, 49(2): e12-e12.
Liu, Xiutao; Feng, Xinjun; Ding, Yamei; Gao, Wenjie; Xian, Mo;Wang, Jichao*; Zhao, Guang*. Characterization and directed evolution of propionyl-CoA carboxylase and its application in succinate biosynthetic pathway with two CO2fixation reactions.Metabolic Engineering, 2020, 62: 42-50.
Yu, Xiao; Afreen, Shagufta; Kong, Qingshan*;Wang, Jichao*. Study on Self-Assembled Morphology and Structure Regulation of alpha-Zein in Ethanol-Water Mixtures.Langmuir, 2020, 36(40): 11975-11984.
Wang, Jichao; Zhang, Tongchuan; Liu, Ruicun; Song, Meilin; Wang, Juncheng; Hong, Jiong; Chen, Quan*; Liu, Haiyan*. Recurring sequence-structure motifs in (βα)8-barrel proteins and experimental optimization of a chimeric protein designed based on such motifs.Biochimica et Biophysica Acta-Proteins and Proteomics, 2017, 1865(2): 165-175.
Ma, Rui;Wang, Jichao; Hou, Zhonghuai*; Liu, Haiyan*. Small-Number Effects: A Third Stable State in a Genetic Bistable Toggle Switch.Physical Review Letters, 2012, 109(24): 248107.