副教授 & 副研究员

李平一

教授
博士/硕士生导师
0532-58632590
个人简介 科研项目 学术论文 其他介绍


教育背景

博士2006-2011 山东大学 微生物学

学士2002-2006 山东大学 生物技术


工作经历

2022.09-至今 山东大学微生物技术国家重点实验室  教授

2018.06-2022.08 山东大学微生物技术国家重点实验室  副研究员

2016.07-2018.05 山东大学海洋研究院  副研究员

2012.02-2015.12 山东大学化学与化工学院  博士后


研究方向

1.海洋环境中高分子量有机质的降解过程及机制研究

2.海洋来源有机碳降解酶的挖掘、功能及结构分析

3.海洋中难培养微生物的富集培养及生理与遗传特征分析

科研项目

1.国家自然科学基金面上项目,42176229,2022.01-2025.12,主持

2.国家自然科学基金重大研究计划培育项目,91751101,2018.01-2020.12,主持

3.国家自然科学基金面上项目,41676180,2017.01-2020.12,主持

4.青岛海洋科学与技术国家实验室开放基金项目,QNLM2016ORP0310,2017.04-2020.03,主持

5.山东大学未来学者计划,2017WLJH57,2017.07-2022.06,主持

6.山东大学基本科研业务费,2016TB010,2016.07-2018.12,主持

7.中国博士后科学基金面上资助,2013M53158,2013.08-2015.08,主持

8.山东省博士后创新基金,201301009,2013.10-2015.10,主持

代表性论文

1. Jiang WX#,Li PY#*, Chen XL, Zhang YS, Wang JP, Wang YJ, Sheng Q, Sun ZZ, Qin QL, Ren XB, Wang P, Song XY, Chen Y, Zhang YZ*. A pathway for chitin oxidation in marine bacteria. Nat Commun, 2022, 13:5899

2. Qin QL#, Wang ZB#, Cha QQ, Liu SS, Ren XB, Fu HH, Sun ML, Zhao DL, McMinn A, Chen Y, Chen XL, Zhang YZ*,Li PY*. Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level. Environ Microbiol, 2022, 24:98-109

3. Zhang Y#, Ding HT#, Jiang WX, Zhang X, Cao HY, Wang JP, Li CY, Huang F, Zhang XY, Chen XL, Zhang YZ*,Li PY*.Active site architecture of an acetyl xylan esterase indicates a novel cold adaptation strategy. J Biol Chem, 2021, 297:100841

4. Wang Y#,Li PY#, Zhang Y, Cao HY, Wang YJ, Li CY, Wang P, Su HN, Chen Y, Chen XL*, Zhang YZ*. 3,6-anhydro-L-galactose dehydrogenaseVvAHGD is a member of a new aldehyde dehydrogenase family and catalyzes by a novel mechanism with conformational switch of two catalytic residues cysteine 282 and glutamate 248. J Mol Biol, 2020, 432:2186-2203

5.Wang YJ, Jiang WX, Zhang YS, Cao HY, Zhang Y, Chen XL, Li CY, Wang P, Zhang YZ, Song XY*, Li PY*. Structural insight into chitin degradation and thermostability of a novel endochitinase from the glycoside hydrolase Family 18. Front Microbiol, 2019, 10:2457

6. Chen XL#, Zhao F#, Yue YS, Zhang XY, Zhang YZ,Li PY*. A new group of modular xylanases in glycoside hydrolase family 8 from marine bacteria. Appl Environ Microbiol, 2018, 84: e01785-18

7.Li PY#, Zhang Y#, Xie BB*, Zhang YQ, Hao J, Wang Y, Wang P, Li CY, Qin QL, Zhang XY, Su HN, Shi M, Zhang YZ, Chen XL*. Structural and mechanistic insights into the improvement of the halotolerance of a marine microbial esterase by increasing intra- and interdomain hydrophobic interactions.Appl Environ Microbiol, 2017, 83: e01286~17

8.Li PY#, Yao QQ#, Wang P, Zhang Y, Li Y, Zhang YQ, Hao J, Zhou BC, Chen XL*, Shi M, Zhang YZ, Zhang XY*.A novel subfamily esterase with a homoserine transacetylase-like fold but no transferase activity. Appl Environ Microbiol, 2017, 83:e00131~17

9.Li PY, Chen XL, Ji P, Li CY, Wang P, Zhang Y, Xie BB, Qin QL, Su HN, Zhou BC, Zhang YZ, Zhang XY*. Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family.J Biol Chem, 2015, 290: 11188~11198

10.Li PY, Ji P, Li CY, Zhang Y, Wang GL, Zhang XY, Xie BB, Qin QL, Chen XL, Zhou BC, Zhang YZ*. Structural basis for dimerization and catalysis of a novel esterase from the GTSAG motif subfamily of the bacterial hormone-sensitive lipase family.J Biol Chem, 2014, 289: 19031~19041

11.Li PY, Xie BB*, Zhang XY, Qin QL, Dang HY, Wang XM, Chen XL, Yu J, Zhang YZ*. Genetic structure of three fosmid-fragments encoding 16S rRNA genes of the Miscellaneous Crenarchaeotic Group (MCG): implications for physiology and evolution of marine sedimentary archaea.Environ Microbiol, 2012, 14: 467~479

所获专利

1.一种双酶催化N-乙酰-D-葡萄糖酸内酯生产2-酮基-3-脱氧-D-葡萄糖酸的方法,ZL202210367611.4,第二位

2. Method for producing 2-keto-3-deoxygluconate from 2-(acetylamino)-2-deoxy-D-gluconic acid by two enzymes, US 11,946,092 B2,第二位

3.一种海洋适冷酯酶及其编码基因E40与应用,ZL201510025698.7,第二位。

4.一种海洋酯酶及其编码基因E32与应用,ZL201510216087.0,第二位。