教育背景
博士 1998.09-2012.06 山东大学 微生物学
硕士 1989.09-1992.06 山东师范大学 植物学
学士 1985.09-1989.06 山东师范大学 生物学
工作经历
起止时间 单位名称 专业技术职务
1992.07-1998.09 山东省农业科学院棉花研究中心 助理研究员
1998.10-2002.08 山东大学微生物技术国家实验室 讲师
2002.09-2004.08 山东大学微生物技术国家实验室 副教授
2004.09-至今 山东大学微生物技术国家实验室 教授
2007-至今 山东大学微生物技术国家实验室 博士生导师
研究方向
海洋微生物科学与技术
主要研究内容：
（1）海洋极端微生物独特的生命特征与环境适应机制及结构基础；
（3）海洋微生物酶学与重要海洋有机碳、氮、磷、硫生物地球化学循环的分子机制；
（3）海洋微生物资源开发与利用技术。
科研项目
1、国家自然科学基金面上项目：诱导细菌胞外蛋白酶表达的胞外诱导物和细胞膜上的信号感应受体研究，2017/01-2020/12，68万元，主持。
2、国家自然科学基金面上项目：深海细菌新型M12家族弹性蛋白酶myroilysin 对胶原蛋白的膨胀机制及应用，2013/01-2016/12，81万元，主持。
3、国家863课题： M23家族金属蛋白酶Pseudoalterin的制备及其抑制耐药性金黄葡萄球菌的应用评价，2014/01-2016/12, 177万元，主持。
4、国家自然科学基金面上项目：海洋细菌分泌的PL18家族褐藻酸裂解酶的成熟机制及其N端结构域的功能、2012/01-2015/12，72万元，主持。
5、国家863课题：海洋适冷表达体系的建立及适冷蛋白酶的重组表达与稳定性改造，2006/01-2012/12，192万元，主持。
代表性论文
1. Fei Xu, Fang Dong, Peng Wang, Hai-Yan Cao, Chun-Yang Li, Ping-Yi Li, Xiu-Hua Pang, Yu-Zhong Zhang,Xiu-Lan Chen*, Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6.J Biol Chem.March 17, 2017， 292, 4457-4468.
2. Ping-Yi Li#, Qiong-Qiong Yao#, Peng Wang, Yi Zhang, Yue Li, Yan-Qi Zhang, Jie Hao, Bai-Cheng Zhou,Xiu-Lan Chen*, Mei Shi, Yu-Zhong Zhang, Xi-Ying Zhang*, A Novel Subfamily Esterase with a Homoserine Transacetylase-like Fold but No Transferase Activity.Applied and Environmental Microbiology, May 2017 Volume 83 Issue 9 e00131-17.
3. Ping-Yi Li#, Yi Zhang#, Bin-Bin Xie*, Yan-Qi Zhang, Jie Hao, Yue Wang, Peng Wang, Chun-Yang Li, Qi-Long Qin, Xi-Ying Zhang, Hai-Nan Su, Mei Shi, Yu-Zhong Zhang,Xiu-Lan Chen*, Structural and Mechanistic Insights intothe Improvement of the Halotolerance of a Marine Microbial Esterase by Increasing Intra- and Interdomain Hydrophobic Interactions.Applied and Environmental Microbiology, 83：e01286-17.
4.Fei Xu, Peng Wang, Yu-Zhong Zhang,Xiu-Lan Chen*, Diversity of Three-Dimensional Structures and Catalytic Mechanisms of Alginate Lyases.Appl Environ Microbiol, 84:e02040-17.
5.Ang Liu, Yang Yu, Qi Sheng, Xiao-Yu Zheng, Jin-Yu Yang, Ping-Yi Li, Mei Shi, Bai-Cheng Zhou, Yu-Zhong Zhang,Xiu-Lan Chen*（2016）Identification of four kinds of 2′, 3′-cNMPs inEscherichia coliand a simple and efficient method for their simultaneous preparation. ACS Chemical Biology11: 2414-2419.
6. Ping-Yi Li,Xiu-Lan Chen, Peng Ji, Chun-Yang Li, Peng Wang, Yi Zhang, Bin-Bin Xie, Qi-Long Qin, Hai-Nan Su, Bai-Cheng Zhou, Yu-Zhong Zhang, and Xi-Ying Zhang*,Interdomain Hydrophobic Interactions Modulate the Thermostability of Microbial Esterases from the Hormone-Sensitive Lipase Family.J. Biol. Chem.2015 290: 11188-11198.
7. Zi-Chao Yu,Xiu-Lan Chen,Qing-Tao Shen, Dian-Li Zhao, Bai-Lu Tang, Hai-Nan Su, Zhao-Yu Wu, Qi-Long Qin, Bin-Bin Xie, Xi-Ying Zhang, Yong Yu, Bai-Cheng Zhou, Bo Chen and Yu-Zhong Zhang* Filamentous phages prevalent inPseudoalteromonasspp. confer properties advantageous to host survival in Arctic sea ice,ISME Journal,2015 Mar 17;9:871-81.
8.Chun-Yang Li, Tian-Di Wei, Sheng-Hui Zhang,Xiu-Lan Chen,Xiang Gao, Peng Wang, Bin-Bin Xie, Hai-Nan Su, Qi-Long Qin, Xi-Ying Zhang, Juan Yu, Hong-Hai Zhang, Bai-Cheng Zhou, Gui-Peng Yang and Yu-Zhong Zhang*, Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide,Proc Natl Acad Sci U S A2014, 111(3):1026-1031.
9.Hui-Lin Zhao,Xiu-Lan Chen,Bin-Bin Xie,Ming-Yang Zhou,Xiang Gao,Xi-Ying Zhang,Bai-Cheng Zhou,Anthony S. WeissandYu-Zhong Zhang*, Elastolytic mechanism of a novel M23 metalloprotease pseudoalterin from deep-sea Pseudoalteromonas sp. CF6-2: cleaving not only glycyl bonds in the hydrophobic regions, but also peptide bonds in the hydrophilic regions involved in crosslinking,J Biol Chem.2012,;287(47):39710-20.
10. Guo-Yan Zhao, Ming-Yang Zhou, Hui-Lin Zhao,Xiu-Lan Chen*, Bin-Bin Xie, Xi-Ying Zhang, Hai-Lun He, Bai-Cheng Zhou, Yu-Zhong Zhang. Tenderization effect of cold-adapted collagenolytic protease MCP-01 on beef meat at low temperature and its mechanism.Food Chem.2012;134(4):1738-44.
