生物与医药

张熙颖

教授
博士/硕士生导师
0532-58632590
个人简介 科研项目 学术论文

教育背景

博士起止时间: 2001-2004毕业院校:山东大学专业:微生物学

硕士起止时间:1994-1997毕业院校:上海医药工业研究院专业:微生物制药

学士起止时间:1990-1994毕业院校:山东大学专业:微生物工程


工作经历

起止时间 单位名称 专业技术职务

2005-2006 国家海洋局厦门第三海洋研究所 博士后(副研究员)

2007.01-2008.09 山东大学 讲师

2008.09-2015.09 山东大学 副教授

2015.09-至今 山东大学 教授

研究方向

1. 海洋微生物多样性,系统学及其可培养化技术

2. 海洋微生物生态功能及其环境适应机制

3. 海洋微生物酶学


科研项目

1. 2021-2024 大洋表层海水中富营养细菌与寡营养细菌共存与互作机制:以Pseudoalteromonas属和Brachybacterium属菌株为例 国家自然基金面上项目

2. 2017-2020 深海细菌及其分泌的M23家族蛋白酶在 深海肽聚糖再循环利用中的作用及机制研究 国家自然基金面上项目

3. 2012-2015 深海新型细菌胶原蛋白酶mycolysin对胶原蛋白 的降解机制及其C端新类型结构域的功能研究 国家自然基金面上项目

4. 2018-2021 极地微生物新型生物制品的研制及其应用潜力评价 国家重点研发计划项目课题

5. 2017-2021 海山区微生物多样性 国家科技基础资源调查专项课题子课题

代表性论文

1.Xiao-Yan He, Ning-Hua Liu, Ji-Qing Liu, Ming Peng, Zhao-Jie Teng, Tie-Ji Gu, Xiu-Lan Chen, Yin Chen, Peng Wang, Chun-Yang Li, Jonathan D Todd, Yu-Zhong Zhang*, Xi-Ying Zhang* (2023) SAR92 clade bacteria are potentially important DMSP degraders and sources of climate-active gases in marine environments. mBio, 14(6): e0146723.

2. Ning-Hua Liu, Jun Ma, Si-Qi Lin, Kui-Dong Xu, Yu-Zhong Zhang, Qi-Long Qin*, Xi-Ying Zhang* (2023) Biogeographic distribution patterns of the bacterial and archaeal communities in two seamounts in the Pacific Ocean. Frontiers in Marine Science. 10: 1160321.

3.Yan Wang, Hai-Nan Su, Hai-Yan Cao, Si-Min Liu, Shi-Cheng Liu, Xia Zhang, Peng Wang, Chun-Yang Li, Yu-Zhong Zhang, Xi-Ying Zhang*, Xiu-Lan Chen* (2022) Mechanistic insight into the fragmentation of type I collagen fibers into peptides and amino acids by a Vibrio collagenase. Applied and Environmental Microbiology, 88(7): e0167721.

4. Jian Li, Jun-Hui Cheng, Zhao-Jie Teng, Zhong-Zhi Sun, Xiao-Yan He, Peng Wang, Mei Shi, Xiao-Yan Song, Xiu-Lan Chen, Yu-Zhong Zhang, Xinmin Tian*, Xi-Ying Zhang* (2021) Taxonomic and enzymatic characterization of Flocculibacter collagenilyticus gen. nov., sp. nov., a novel gammaproteobacterium with high collagenase production. Frontiers in Microbiology, 12: 621161.

5. Shan Zhang, Wei-Xiong Liu, Ning-Hua Liu, Xiao-Yan He, Hai-Nan Su, Chun-Yang Li, Yu-Zhong Zhang, Xiao-Yan Song, Xi-Ying Zhang* (2020). Antarcticimicrobium sediminis gen. nov., sp. nov., isolated from Antarctic intertidal sediment, transfer of Ruegeria lutea to Antarcticimicrobium gen. nov. as Antarcticimicrobium luteum comb. nov. International Journal of Systematic and Evolutionary Microbiology 70(4): 2624-2631.

6. Xiu-Lan Chen#, Jin-Yu Yang#, Xiao-Yu Zheng, Qi Sheng, Lei Wang, Yu-Zhong Zhang, Qi-Long Qin*, Xi-Ying Zhang* (2019) Tripeptides from casein are signal molecules to induce the expression of the extracellular protease MCP-01 gene in marine bacterium Pseudoalteromonas sp. SM9913. Frontiers in Microbiology, 10: 1354.

7. Ping-Yi Li, Qiong-Qiong Yao, Peng Wang, Yi Zhang, Yue Li, Yan-Qi Zhang, Jie Hao, Bai-Cheng Zhou, Xiu-Lan Chen *, Mei Shi, Yu-Zhong Zhang and Xing-Ying Zhang*, A novel subfamily esterase with a homoserine transacetylase-like fold but no transferase activity. Applied and Environmental Microbiology, 2017, 83(9): pii: e00131-17.

8. Ning Wang#, Fei Xu#, Xi-Ying Zhang*, Xiu-Lan Chen, Qi-Long Qin, Bai-Cheng Zhou, Yu-Zhong Zhang, Mei Shi* (2017) Changchengzhania lutea gen. nov., sp. nov., a new member of the family Flavobacteriaceae isolated from Antarctic intertidal sediment. Journal of Systematic and Evolutionary Microbiology, 67(12):5187-5192.

9. Xi-Ying Zhang, Xiao-Xu Han, Xiu-Lan Chen, Hong-Yue Dang, Bin-Bin Xie, Qi-Long Qin, Mei Shi*, Bai-Cheng Zhou, Yu-Zhong Zhang (2015) Diversity of cultivable protease-producing bacteria in sediments of Jiaozhou Bay, China. Frontiers in Microbiology, 6: 1021.

10. Ping-Yi Li, Xiu-Lan Chen, Peng Ji, Chun-Yang Li, Peng Wang, Yi Zhang, Bin-Bin Xie, Qi-Long Qin, Hai-Nan Su, Bai-Cheng Zhou, Yu-Zhong Zhang, Xi-Ying Zhang* (2015) Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family. Journal of Biological Chemistry, 290(17): 11188-11198.

11. Chun-Yang Li, Xiu-Lan Chen, Qi-Long Qin, Peng Wang, Wei-Xin Zhang, Bin-Bin Xie, Hai-Nan Su, Xi-Ying Zhang*, Bai-Cheng Zhou, Yu-Zhong Zhang (2015) Structural insights into the multispecific recognition of dipeptides of deep-sea gram-negative bacterium Pseudoalteromonas sp. strain SM9913. Journal of Bacteriology, 197(6): 1125-1134.

12. Li-Yuan Ran, Hai-Nan Su, Ming-Yang Zhou, Lei Wang, Xiu-Lan Chen, Bin-Bin Xie, Xiao-Yan Song, Mei Shi, Qi-Long Qin, Xiuhua Pang, Bai-Cheng Zhou, Yu-Zhong Zhang*, Xi-Ying Zhang* (2014) Characterization of a novel subtilisin-like protease myroicolsin from deep sea bacterium Myroides profundi D25 and molecular insight into its collagenolytic mechanism. Journal of Biological Chemistry, 289(9): 6041-6053.

13. Qi-Long Qin#, Xi-Ying Zhang#, Xu-Min Wang, Gui-Ming Liu, Xiu-Lan Chen, Bin-Bin Xie, Hong-Yue Dang, Bai-Cheng Zhou, Jun Yu, Yu-Zhong Zhang* (2010) The complete genome of Zunongwangia profunda SM-A87 reveals its adaptation to the deep-sea environment and ecological role in sedimentary organic nitrogen degradation. BMC Genomics, 11:247.