代表性论文
1. Ye, Y. #, Du, L. #, Zhang, X.,Newmister, S. A.,McCauley, M.,Alegre-Requena, J. V., Zhang, W., Mu, S.,Minami, A.,Fraley, A. E.,Adrover-Castellano, M. L.,Carney, N. A., Shende, V. V., Qi, F.,Oikawa, H., Kato, H.,Tsukamoto, S., Paton, R. S.,Williams, R. M.*, Sherman, D. H.*, andLi, S.* Fungal-derived Brevianamide assembly by a stereoselective semi-pinacolase.Nat. Catal.(Accepted)
2. Li, S.*, Du, L., and Bernhardt, R.* Redox partners: Function modulators of bacterial P450 enzymes.Trends Microbiol. 2020, doi.org/10.1016/j.tim.2020.02.012.
3. Jiang, Y., Li, Z., Zheng, S., Xu, H., Zhou, Y. J., Gao, Z., Meng, C. *, andLi, S.* Establishing an enzyme cascade for one-pot production of α-olefns from low-cost triglycerides and oils without exogenous H2O2 addition.Biotechnol. Biofuels 2020, 13, 52.
4. Xu, H., Liang, W., Ning, L., Jiang, Y., Yang, W., Wang, C., Qi, F., Ma, L., Du, L., Fourage, L., Zhou, Y. J. andLi, S.* Directed Evolution of P450 Fatty Acid Decarboxylases via High-Throughput Screening towards Improved Catalytic Activity.ChemCatChem 2019, 11, 1-6..
5. Liu, K., andLi, S.* Biosynthesis of fatty acid derived hydrocarbons: perspectives on enzymology and enzyme engineering,Curr. Opin. Biotech.2019, 62, 7-14.
6. Zhang, W., Du, L., Qu, Z., Zhang, X., Li, F., Li, Z., Qi, F., Wang, X., Jiang, Y., Men, P., Sun, J., Cao, S., Geng, C., Qi, F., Wan, X., Liu, C., andLi, S.* Compartmentalized Biosynthesis of Mycophenolic Acid.Proc. Natl. Acad. Sci. U.S.A. 2019, 116(27), 13305-13310.
7. Jiang, Y., Li, Z., Wang, C., Zhou, Y. J., Xu, H.*, andLi, S.*Biochemical characterization of three newα-olefn-producing P450 fatty acid decarboxylases with a halophilic property.Biotechnol. Biofuels 2019, 12, 79.
8. Zhang, W. #, Du, L. #, Li, F., Zhang, X., Qu, Z., Han, L., Li, Z., Sun, J., Qi, F., Yao, Q., Sun, Y., Geng, C.,Li, S.* Mechanistic insights into interactions between bacterial class I P450 enzymes and redox partners.ACS Catal. 2018, 8, 9992-10003.
9. Jiang, Y.,Li, S.* The catalytic function and application of cytochrome P450 enzymes in biosynthesis and organic synthesis.Chin. J. Org. Chem. 2018,38(9), 2307-2323.
10. Qi, F. #, Lei, C. #, Li, F., Zhang, X., Wang, J., Zhang, W., Fan, Z., Li, W., Tang, G., Xiao, Y.*, Zhao, G.,Li, S. * Deciphering the late steps of rifamycin biosynthesis.Nat. Commun.2018, 9,2342.
11. Chen, H., Meng, X., Xu, X., Liu, W.,Li, S. *The molecular basis for lipase stereoselectivity.Appl. Microbiol. Biotechnol. 2018,102(8),3487-3495.
12. Xu, H., Ning, L., Yang, W., Fang, B., Wang, C., Wang, Y., Xu, J., Colin, S., Laeuffer, F., Fourage, L., andLi, S. * In vitrooxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases.Biotechnol. Biofuels2017, 10,208.
13. Zhang, X., andLi, S.* Expansion of chemical space for natural products by uncommon P450 reactions.Nat. Prod. Rep. 2017, 34(9), 1061-1089.
14. Du, L. #, Dong, S. #, Zhang, X., Jiang, C., Chen, J., Yao, L., Wang, X., Wan, X., Liu, X., Wang, X., Huang, S., Cui, Q., Feng, Y. *, Liu, S.*, andLi, S.*Selective oxidation of aliphatic C–H bonds in alkylphenols by a chemomimetic biocatalytic system.Proc. Natl. Acad. Sci. U.S.A. 2017,114(26), E5129-E5137.
15. Li, Z., Du, L., Zhang, W., Zhang, X., Jiang, Y., Liu, K., Men, P., Xu, H., Fortman, J. L., Sherman, D. H., Yu, B., Gao, S.,Li, S.* Complete elucidation of the late steps of bafilomycin bios ynthesis inStreptomyces lohii.J. Biol. Chem. 2017,292(17), 7095-7104.
16. Fang, B. #, Xu, H. #, Liu, Y., Qi, F., Zhang, W., Chen, H., Wang, C., Wang, Y., Yang, W., andLi, S.* Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleTJE.Sci. Rep.2017, 7, 44258.
17. 孙月, 马莉, 陈辉, 徐卉芳, 郑贤良, 齐凤霞, 李盛英*. 脂肪酶—P450脂肪酸脱羧酶融合蛋白催化的α烯烃合成[J].科学通报, 2017, 62(31), 3576-3582.
18. Sun, Y. #, Ma, L. #, Han, D. #, Du, L., Qi, F., Zhang, W., Sun, J., Huang, S., Kim, E.-S.,* andLi, S.* In vitro reconstitution of the cyclosporine specific P450 hydroxylases using heterologous redox partner proteins. J. Ind. Microbiol. Biotechnol.2016, 44(2),161-166.
19. Zhang, X., Li, Z., Du, L., Chlipala, G. E., Lopez, P. C., Zhang, W., Sherman, D. H.*, andLi, S.* Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.Tetrahedron Lett. 2016, 57(52), 5919-5923.
20. Zheng, X., Fang, B., Han, D., Yang, W., Qi,F., Chen, H., andLi, S.* Improving the Secretory Expression of an α-Galactosidase fromAspergillus niger in Pichia pastoris.PLoS ONE 2016,11(8), e0161529.
21. Du, L., Ma, L., Qi, F., Zheng, X., Jiang, C., Li, A., Wan, X., Liu, S.-J.*, andLi, S.* Characterization of a unique pathway for 4-cresol catabolism initiated by phosphorylation inCorynebacterium glutamicum. J. Biol. Chem. 2016, 291(12), 6583-6594.
22. 李众, 张伟, 李盛英*. 细胞色素P450酶与微生物药物创制[J].微生物学报, 2016, 56(3), 496-515.
23. Ma, L., Du, L., Chen, H., Sun, Y., Huang, S., Zheng, X., Kim, E.-S.*, andLi, S.*Reconstitution of the in vitro activity of the cyclosporine-specific P450 hydroxylase fromSebekia benihana and development of a heterologous whole cell biotransformation system. Appl. Environ. Microbiol. 2015, 81(18), 6268-6275.
24. Yan, J.*, Liu, Y., Wang, C., Han, B., andLi, S.*Assembly of lipase and P450 fatty acid decarboxylase to constitute a novel biosynthetic pathway for production of 1-alkenes from renewable triacylglycerols and oils.Biotechnol. Biofuels 2015, 8, 34.
25. Zhang, W., Cao, S., Qiu, L., Qi, F., Li, Z., Yang, Y., Huang, S., Bai, F., Liu, C., Wan, X.,* andLi, S.* Functional Characterization of MpaG’, theO-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid.Chembiochem 2015, 16(4), 565-569.
26. Yan, J.*, Zheng, X., Du, L., andLi, S.* Integrated lipase production and in situ biodiesel synthesis in a recombinant Pichia pastoris yeast: an efficient dual biocatalytic system composed of cell free enzymes and whole cell catalysts.Biotechnol. Biofuels 2014, 7, 55.
27. Zhang, W., Liu, Y., Yan, J., Cao, S., Bai, F., Yang, Y., Huang, S., Yao, L., Anzai, Y., Kato, F., Podust, L. M., Sherman, D. H.*, andLi, S.* New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.J. Am. Chem. Soc. 2014, 136(9), 3640-3646. (Faculty of 1000 Prime: http://f1000.com/prime/718276150)
28. Liu, Y., Wang, C., Yan, J., Zhang, W., Guan, W., Lu, X., andLi, S.* Hydrogen peroxide-independent production ofα-alkenes by OleTJE P450 fatty acid decarboxylase.Biotechnol. Biofuels 2014, 7, 28.
29. Yan, J.*, Zheng, X., andLi, S.* A novel and robust recombinantPichia pastoris yeast whole cell biocatalyst with intracellular overexpression of aThermomyces lanuginosus lipase: preparation, characterization and application in biodiesel production.Bioresour. Technol. 2014, 151, 43-48.
30. Zhang W., Fortman, J. L., Carlson, J. C., Yan, J., Liu, Y., Bai, F., Guan, W., Jia, J., Matainaho, T., Sherman, D. H.*, andLi, S.* Characterization of the bafilomycin biosynthetic gene cluster fromStreptomyces lohii.Chembiochem, 2013, 14(3), 301-306.
31. Li, S., Tietz, D. R., Rutaganira, F. U., Kells, P. M., Anzai, Y., Kato, F., Pochapsky, T. C., Sherman, D. H., and Podust, L. M.*Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions.J. Biol. Chem. 2012, 287(45), 37880-37890.
32. Li, S., Anand, K., Tran, H., Yu, F., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Tsukamoto, S., Williams, R. M.*, and Sherman, D. H.*Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.MedChemComm 2012, 3(8), 987-996.
33. Li, S., Finefield, J. M., Sunderhaus, J. D., McAfoos, T. J., Williams, R. M.*, and Sherman, D. H.*Biochemicalcharacterization of NotB as an FAD-dependentoxidase in thebiosynthesis ofnotoamideindolealkaloids.J. Am. Chem. Soc.2012, 134(2), 788-791.
34. Carlson, J. C.#,Li, S. #, Gunatilleke, S. S., Anzai, Y., Burr, D. A., Podust, L. M., and Sherman, D. H.* Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes.Nat. Chem.2011, 3(8), 628-633.
35. Carlson, J. C. #,Li, S.#, Douglas, A. B., and Sherman, D. H.*Isolation and characterization of tirandamycins from a marine-derivedStreptomyces sp.J. Nat. Prod. 2009, 72(11), 2076-2079.
36. Li, S., Chaulagain, M. R., Knauff, A. R., Podust, L. M., Montgomery, J.*, and Sherman, D. H.* Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 monooxygenase.Proc. Natl. Acad. Sci. U.S.A. 2009, 106(44), 18463-18468.
37. Li, S.,Anzai, Y., Kinoshita, K., Kato, F., Sherman, D. H.* Functional analysis of MycE and MycF, twoO-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.Chembiochem 2009, 10(8), 1297-1301.
38. Li, S., Ouellet, H.,Sherman, D. H., Podust, L. M.* Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC fromStreptomyces venezuelae.J. Biol. Chem. 2009, 284(9), 5723-5730.
39. Anzai, Y. #,Li, S. #, Chaulagain, M. R., Kinoshita, K., Kato, F., Montgomery, J., Sherman, D. H.*Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics.Chem. Biol. 2008, 15(9), 950-959.
40. Li, S., Podust, L. M., Sherman, D. H.*Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.J. Am. Chem. Soc. 2007, 129(43), 12940-12941.
41. Li, S., Grüschow, S., Dordick, J. S., Sherman, D. H.*Molecular analysis of the role of tyrosine 224 in the active site ofStreptomyces coelicolor RppA, a bacterial type III polyketide synthase.J. Biol. Chem. 2007, 282(17), 12765-12772.
42. Li, S., Wang, J., Zheng, Z., Xu, Q., Huang, Y., Zhao, Y., Su, W.*1-(2,4-Dihydroxy-3,5-Dimethylphenyl)-ethanone (Clavatol).Acta. Cryst. 2003, E59, o1649-o1650.
43. 李盛英, 郑忠辉*. 国外海洋抗肿瘤活性物质的研究与开发[J].海洋通报,2003, 22(2), 76-82.