教育背景

博士：1996.9-2000.7；华中农业大学；生物化学与分子生物学

硕士：1989.9-1992.7；中国科学院武汉病毒研究所；病毒学

学士：1985.9-1989.7；山东师范大学；普通生物学

工作经历

起止时间 单位名称 专业技术职务 

2009.3-至今 山东大学 教授

2004.3-2009.12 University of Texas Health Science Center at Tyler (USA) Instructor, Research associate senior, Post-doc.

2001.5-2004.2 University of Nancy I (France), Post-doc.

1.放线菌的代谢调控及生物学

2．放线菌的资源挖掘与利用

3.微生物的生物降解及应用

4．海洋微生物的酶及应用

科研项目

1，国家重点研发计划（2018YFC0310603），主持（子课题）

2，国家重点研发计划（2016YFA0601303），主持（子课题）

3，国家自然科学基金面上项目（32270072），主持

4，国家自然科学基金应急项目（31741001），主持

5，国家自然科学基金面上项目（31470165），主持

6，国家自然科学基金面上项目（81171540），主持

7，国家自然科学基金面上项目（81071328），主持

8，山东省自然科学基金面上项目（ZR2019MC062），主持

9，山东省自然科学基金面上项目（ZR2010HM007），主持

研究论文

*:通讯作者

★ Zhu Y,Wang X, Zhang J, Ni X, Zhang X, Tao M,andPang X*. 2022.wblAis the target of the orphan response regulatorOrrA inStreptomyces coelicolor. EnvironmentalMicrobiology 24(7):3081-3096.

★Zhu Y, Wang J, Su W, Ting Lu, Li A, andPang X*. 2022.Effects of dual deletion ofglnR andmtrA on the expression ofnitrogen metabolism genes inStreptomyces venezuelae.MicrobialBiotechnology 15(6):1795-1810.

★Zhu Y, Lu T, Ni X, Zhang X, Liu Y, Cui X,andPang X*. 2022. Mutation of MtrA at the predicted phosphorylation site abrogates its role as a global regulatorinStreptomycesvenezuelae.MicrobiologySpectrum 10(2):e0213121.

★Zhu Y,Zhang P,LuT, Wang X, Li A, Lu Y, Tao M, andPang X*.2021. Impact of MtrA on phosphate metabolism genes and the response to altered phosphate conditions inStreptomyces. EnvironmentalMicrobiology23(11):6907-6923.

★ Liu M, Xu W, Zhu Y, Cui X, andPang X*.2021. The response regulator MacR and its potential in improvement of antibiotic production inStreptomyces coelicolor. Current Microbiology 78 (10):3696-3707.

★Zhu Y,Lu T, Zhang J, Tao M, andPang X*. 2020.A novel XRE-family regulator that controls antibiotic production and development inStreptomyces coelicolor. Applied Microbiology and Biotechnology104 (23):10075-10089.

★Zhu Y,Zhang P,Zhang J,Wang J,Lu Y,andPang X*. 2020. Impact on multiple antibiotic pathways reveals MtrA as a master regulator of antibiotic production in Streptomyces and potentially in other actinobacteria.Applied and Environmental Microbiology 86 (20): e01201-20.

★Zhu Y,Xu W, ZhangP,Zhao Z, Sheng D, Ma W, Zhang YZ, Bai L, andPang X*. 2020.A hierarchical network of four regulatory genes controls production of the polyene antibiotic Candicidin inStreptomyces sp. FR-008.Applied and Environmental Microbiology 86(9): e00055-20.

★Zhu Y, Zhang P, Zhang J, Xu W, Wang X, Wu L, Sheng D, Ma W, Cao G, Chen X, Lu Y, Zhang Y, andPang X*. 2019. The developmental regulator MtrA binds GlnR boxes and represses nitrogen metabolism genes inStreptomyces coelicolor.Molecular Microbiology 112 (1):29-46.

★ Liu M, Zhang P, Zhu Y, Lu T, Wang Y, Cao, G, Shi M, Chen X, Tao M, andPang X*. 2019. Novel Two-Component system MacRS is a pleiotropic regulator that controls multiple morphogenic membrane protein genes in Streptomyces coelicolor.Applied and Environmental Microbiology 85 (4): e02178-18.

★ Lu T, Zhu Y, Zhang P, Sheng D, Cao G,Pang X*. 2018. SCO5351 is a pleiotropic factor that impacts secondary metabolism and morphological development inStreptomyces coelicolor. FEMS Microbiology Letter 365 (17), fny150.

★ Zhang P, Wu L, Zhu Y, Liu M, Wang Y, Cao G, Chen XL, Tao M,Pang X*. 2017. Deletion of MtrA inhibits cellular development ofStreptomyces coelicolor and alters expression of developmental regulatory genes.Frontiers in Microbiology 8:2013(1-18).

★Cao G, Zhang P, Gu Y,Pang X*. 2017.Gene Over expression inStreptomyces hygroscopicusAssociated with DNA amplification.Current Microbiology74:979-86.

★ Zhao Z, Shi T, Xu M, Brock NL, Zhao YL, Wang Y, Deng Z,Pang X*, Tao M*. 2016. Hybrubins: Bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes.OrganicLETTERS 18(3):572-5.

★ Cao G, Howard ST, Zhang P, Wang X, Chen XL, Samten B, andPang X*. 2015.EspR, a regulator of the ESX-1 secretion system inMycobacterium tuberculosis, is directly regulated by the two-component systemsMprAB and PhoPR.Microbiology 161(3):477-489.

★ Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, andPang X*. 2015. Production of the antibiotic FR-008/Candicidin inStreptomyces sp. FR-008 is coregulated by two regulators, FscRI and FscRIV, from different transcription factor families.Microbiology 161(3):539-552.

★ Zhang P, Wu H, Chen XL, Deng Z, Bai L, andPang X*. 2014. Regulation of the Biosynthesis of Thiopeptide Antibiotic Cyclothiazomycin by a Transcriptiona1 Regulator SHJG8833 inStreptomyces hygroscopicus 5008.Microbiology 160 (7):1379-1392.

★ Pang X*, Samten B, Cao G, Wang X, Tvinnereim A, Chen X, and Howard ST. 2013. MprAB regulates theespA operon inMycobacterium tuberculosis, and modulates ESX-1 function and host cytokine response.Journal ofBacteriology 195(1):66-75.

★ Pang X, Howard ST. 2007. Regulation of the alpha-crystallin gene acr2 by the MprAB two-component system ofMycobacterium tuberculosis. Journal ofBacteriology 189(17):6213-21.

★ Pang X, Vu P, Byrd TF, Ghanny S, Soteropoulos P, Mukamolova GV, Wu S, Samten B, Howard ST. 2007. Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant ofMycobacterium tuberculosis.Microbiology 153(4):1229-42.

★ Aigle B†,Pang X†, Decaris B, Leblond P. 2005. Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the dupliated type II polyketide synthase alp gene cluster inStreptomyces ambofaciens.Journal ofBacteriology 187(7):2491-500.

★ Pang X, Aigle B, Girardet JM, Mangenot S, Pernodet JL, Decaris B, Leblond P. 2004. Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of theStreptomyces ambofaciens linear chromosome.AntimicrobialAgents andChemotherapy 48(2):575-88.

★ Pang X, Zhou X, Sun Y, Deng Z. 2002.Physical map of the linear chromosome ofStreptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions.Journal ofBacteriology 184(7):1958-65.