医药微生物技术

张坤迪

助理研究员
硕士生导师
0532-58632445
个人简介 科研项目 学术论文 其他介绍

教育背景:

(1) 2013-09至2017-06,中国科学院青岛生物能源与过程研究所,生物化学与分子生物学,博士

(2) 2007-09至2009-06,武汉大学,微生物学,硕士

(3) 2003-09至2007-06,哈尔滨工业大学,生物工程,学士


工作经历:

(1) 2018-03至今,山东大学,微生物技术国家重点实验室(研究院),助理研究员

(2) 2012-02至2018-03,中国科学院青岛生物能源与过程研究所,分子微生物工程团队,助理研究员

(3) 2009-08至2012-12,中国科学院青岛生物能源与过程研究所,微生物资源团队,研究实习员


研究方向:

病原微生物的耐药性及生物被膜形成机制;病原微生物生物被膜成分鉴定及治疗方法的开发

主要项目:

(1)国家自然科学基金委员会面上项目,绿脓菌素调控铜绿假单胞菌多药物外排泵MexAB–OprM表达的分子机制, 2023-01-01至2026-12-31 ,在研,参与

(2)国家自然科学基金委员会面上项目,非催化域结构差异影响外切纤维素酶I降解结晶纤维素效率的机制研究, 2022-01-01至2025-12-31,在研,参与

(3)国家自然科学基金委员会面上项目,YdiV通过控制Fur蛋白折叠路径调控大肠杆菌铁代谢的分子机制, 2020-01-01至2023-12-31,资助期满,参与

(4)山东省自然科学基金委面上项目,阴道加德纳菌山东省流行株的比较基因组学及致病机制研究, 2022-01至2024-12,在研,主持

(5)中国博士后科学基金会面上项目,阴道加德纳菌生物被膜形成与致病性的关系研究, 2018-11至2020-11,结题,主持

代表性论文:

(1)Kundi Zhang; Dandan Jiang; Wolfgang Liebl; Maofeng Wang; Lichuan Gu; Ziyong Liu; Armin Ehrenreich; Confirmation of glucose transporters through targeted mutagenesis and transcriptional analysis in Clostridium acetobutylicum, Fermentation, 2023, 9(64)

(2)Kundi Zhang; Mengyao Lu; Yuxin Qiu; Xiaoxuan Zhu; Hongwei Wang; Yan Huang; Hongjie Dong; Lichuan Gu; Transcriptomic and Proteomic Analysis of Gardnerella vaginalis Responding to Acidic pH and Hydrogen Peroxide Stress, Microorganisms, 2023, 11(3): 695

(3)Fengyu Zhang; Yipeng Wang; Xiaomeng Wang; Hongjie Dong; Min Chen; Ning Du; Hongwei Wang; Wei Hu;Kundi Zhang*; Lichuan Gu*; RT-IVT method allows multiplex real-time quantification of in vitro transcriptional mRNA production, Communications Biology, 2023, 6(1): 453-453

(4)Hongjie Dong#;Kundi Zhang#; Junmei Zhang; Yumeng Xiao; Fengyu Zhang; Maofeng Wang; Hongwei Wang; Guihua Zhao; Shiling Xie; Xiaohong Xie; Wei Hu; Kun Yin; Lichuan Gu; A fast RT-qPCR system significantly shortens the time for SARS-CoV-2 nucleic acid test, Drug Discoveries & Therapeutics, 2023, 17(1): 37-44

(5) Maofeng Wang, Cancan Wu, Nan Liu, Fengyu Zhang, Hongjie Dong, Shuai Wang, Min Chen, Xiaoqiong Jiang,Kundi Zhang*, Lichuan Gu*; SARS-CoV-2 RdRp uses NDPs as a substrate and is able to incorporate NHC into RNA from diphosphate form molnupiravir, International Journal of Biological Macromolecules, 2023, 226: 946-955

(6)Kundi Zhang; Mengyao Lu; Xiaoxuan Zhu; Kun Wang; Xuemei Jie; Tan Li; Hongjie Dong; Rongguo Li; Fengyu Zhang; Lichuan Gu; Antibiotic resistance and pathogenicity assessment of various Gardnerella sp. strains in local China, Frontiers in Microbiology, 2022, 13

(7)Kundi Zhang; Wen Li; Yefei Wang; Yanlin Zheng; Fangcheng Tan; Xiaoqing Ma; Lishan Yao; Bayer Edward A; Lushan Wang; Fuli Li; Processive Degradation of Crystalline Cellulose by a Multimodular Endoglucanase via a Wirewalking Mode, Biomacromolecules, 2018, 19(5): 1686-1696

(8) Min Yang#;Kundi Zhang#; Peiyu Zhang; Xia Zhou; Xiaoqing Ma; Fuli Li; Synergistic Cellulose Hydrolysis Dominated by a Multi-Modular Processive Endoglucanase from Clostridium cellulosi, Frontiers in Microbiology, 2016, 7

(9)Kundi Zhang; Chen, Xiaohua; Schwarz, Wolfgang H; Li, Fuli; Synergism of glycoside hydrolase secretomes from two thermophilic bacteria cocultivated on lignocellulose, Applied and Environmental Microbiology, 2014, 80(8): 2592-2601

(10)Kundi Zhang, Fuli Li*, Isolation and Characterization of a Chromium-resistant BacteriumSerratiasp. Cr-10 from a Chromate-contaminated Site, Appl Microbiol Biotechnol, 2011, 90(3): 1163-1169.

(11)Kundi Zhang, Yang Wang, Yali Tang, Jun Dai, Lei Zhang, Hongli An, Guangchao Luo,Erkin Rahman and Chengxiang Fang*.Niastella populisp. nov., isolated from soil of Euphrates poplar (Populus euphratica) forest, and emended description of the genusNiastella, Int J Syst Evol Microbiol, 2010, 60(7): 542-545.

(12)Kundi Zhang, Yali Tang, Lei Zhang, Jun Dai, Yang Wang, Xuesong Luo, Ming Liu, Guangchao Luo and Chengxiang Fang*.Parasegetibacter luojiensisgen. nov., sp. nov., a novel member of the phylumBacteroidetes,isolated from a Euphrates poplar(Populus euphratica)forest, Int J Syst Evol Microbiol, 2009, 59(12): 3058-3062.

(1)李福利;吕明;苏航;马小清;张坤迪;生物质多糖降解酶功能和催化机制研究,山东省科学技术厅,自然科学,省部二等奖, 2021

(2)李福利;张坤迪;王禄山;一种主产物为纤维四糖的重组纤维素酶及其构建方法和应用, 2022-10-25,中国,专利号CN201810073315.7

(3)谷立川;王茂凤;张坤迪;许素娟;一种降低蛋白质变性温度的方法及其突变体与应用, 2023-07-18,中国,专利号CN202210997990.5

(4)谷立川;肖雨萌;张坤迪;许素娟;一种双Y型纳米抗体及其组装方法和应用, 2023-06-21,中国,专利号CN202310747252.X