代表性论文
2017年至今：
（1）Dongdong Wang #，Zhe Chen #，Chunyu Xu，Xuyao Jiao，Min Yue，Xiang Gao*. (2025) Functional synergy of heteropentameric B subunits underlies virulence in a Salmonella A2B5 toxin.PLoS Pathog.21(11):e1013684.(#, Co-first author)
（2）Piqian Gong, Guobang Li, Weixun Li, Mengyuan Xu, Xuyao Jiao, Xudong Chen, Beile Gao,Xiang Gao*.(2025) Cryo-EM structure of the QseG-QseE complex reveals an accessory protein-driven two-component system activationmechanism.mBio.Published onlineNov 17,2025.
（3）Weixun Li , Shuaining Zheng , Xiaoning Xu , Jing He , Xuyao Jiao , Mingyu Wang , Wei Hu , Shengying Li , Xianzhi Jiang , Bentley Lim , Feng Shao ,Xiang Gao*. (2025) A conserved adaptor orchestrates co-secretion of synergistic type VI effectors in gut Bacteroidota.Cell Host & Microbe.33(11):1901-1915.
（4）Jing He, Zhe Chen, Kun Jiang, Yan Yang, Weixun Li , Xiaotong Wang, Xiaoning Xua, Shuaining Zheng, Xuyao Jiao, Xudong Chen , Liujie Huo, Bentley Lim, Shuang-Jiang Liu, andXiang Gao*.(2025) A nonenzymatic effector disrupts Bacteroides cell wall homeostasis via OmpA targeting to mediate interbacterial competition.PNAS.122(41):e2513207122.
（5）Weixun Li，Xiang Gao*.(2025) Structural plasticity of bacterial ubiquitin-like proteins in stress sensing.STRUCTURES.33(6):989-991.
（6）Yuanyuan Jiang#, Piqian Gong#, Zijia Li#, Zhong Li, Yuxuan Li, Binju Wang, He Huang*, Wei Peng*,Xiang Gao*, and Shengying Li* (2025) Unexpected Activities of CYP152 Peroxygenases towards Non-carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility.Angewandte Chemie International Edition.64(31): e202506614.(#, Co-first author)
（7）Kun Jiang#, Xinxin Pang#, Weixun Li#, Xiaoning Xu, Yan Yang, Chengbin Shang &Xiang Gao*.（2025）Interbacterial warfare in the human gut: insights from Bacteroidales’ perspective.Gut Microbes.17(1)：2473522.(#, Co-first author)
（8）Xiao Ding , Nick Lung-Ngai Ting , Chi Chun Wong , Pingmei Huang , Lanping Jiang , Chuanfa Liu , Yufeng Lin , Shiyu Li , Yujie Liu , Mingxu Xie , Weixin Liu , Kai Yuan , Luyao Wang , Xinyue Zhang , Yanqiang Ding , Qing Li , Yang Sun , Yinglei Miao , Lanqing Ma ,Xiang Gao, Weixun Li, William K K Wu , Joseph J Y Sung , Sunny Hei Wong , Jun Yu*. (2025) Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity.Cell Host &Microbe.33(6):941-956.
（9）Yuqing Yan , Li Tian , Ying Zhao , Baoqin Xuan , Xitao Xu , Jinmei Ding , Weixun Li , Yi-Lu Zhou , Yue Zhang , Yanru Ma , Lijun Ning , Zhenyu Wang , Yi Jiang , Xiaoqiang Zhu , Xiaowen Huang , Muni Hu , Nan Shen ,Xiang Gao, Jing-Yuan Fang , Zhe Cui *, Zhijun Cao* , Haoyan Chen* , Xiaoyan Wang* , Jie Hong*. (2025) Bacteroides fragilis Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease.J Crohns Colitis.19(3):jjae179.
（10）Bentley Lim, Jinghua Xu, Igor H. Wierzbicki, Carlos G. Gonzalez, Zhe Chen, David J. Gonzalez,Xiang Gao, and Andrew L. Goodman*. (2025) A human gut bacterium antagonizes neighboringbacteria by altering their protein-folding ability.Cell Host &Microbe.33(2):200-217.
（11）Ming Tong#,Jinghua Xu#,Weixun Li#,Kun Jiang#,Yan Yang,Zhe Chen, Xuyao Jiao,Xiangfeng Meng,Mingyu Wang,Jie Hong,Hongan Long,Shuangjiang Liu,Bentley Lim, andXiang Gao*(2024)A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues.Nat Commun.15:8794. (#, Co-first author).
（12）Kun Jiang*,Xiang Gao*(2024)Current advances on Vip3 highlight the promising potential of bacterial insecticidal proteins,Trends in Microbiology.32(8):732-735.
（13）Kun Jiang#, Weixun Li#, Ming Tong#, Jinghua Xu#, Zhe Chen#, Yan Yang, Yuanrong Zang, Xuyao Jiao, Chang Liu, Bentley Lim, Xianzhi Jiang, Jiawei Wang, Dalei Wu, Mingyu Wang, Shuang-Jiang Liu, Feng Shao, andXiang Gao*(2023) Human Gut Symbionts Secrete a Ubiquitin Homologue that Inactivates an Essential Periplasmic Chaperone for Interbacterial Competition.Nature Microbiology.9(1):70-84. (#, Co-first author).
（14）KunJiang#,ZheChen#, Yuanrong Zang, Yiting Shi, Chengbin Shang, XuyaoJiao, Jun Cai,Xiang Gao*（2023）Functional Characterization of Vip3Aa from Bacillus Thuringiensis Reveals the Contributions of Specific Domains to Its Insecticidal Activity.J Biol Chem.299(3):103000.（#, Co-first author）.
（15）Yunjun Pan#, Guobang Li#, Ruxin Liu, Jiawei Guo, Yunjie Liu, Mingyu Liu, Xingwang Zhang, Luping Chi, Kangwei Xu, Ruibo Wu, Yuzhong Zhang, Yuezhong Li,Xiang Gao*, Shengying Li*(2023) Unnatural Activities and Mechanistic Insights of Cytochrome P450 PikC Gained from Site-specific Mutagenesis by Non-canonical Amino Acids.Nat Commun,14(1):1669.（#, Co-first author）.
（16）Zhe Chen, Yiting Shi, Dongdong Wang, Xiaoyu Liu, Xuyao Jiao,Xiang Gao*, Kun Jiang*(2023)Structural insight into Bacillus thuringiensis Sip1Ab reveals its similarity to ETX_MTX2 family beta-pore-forming toxin.Pest Manag Sci.79(11):4264-4273.
（17）KunJiang#,ZheChen#,YitingShi,YuanrongZang,ChengbinShang,XiHuang,JiaheZang,ZhudongBai,XuyaoJiao,JunCai,XiangGao*.(2023)A Strategy to Enhance the Insecticidal Potency of Vip3Aa by Introducing Additional Cleavage Sites to Increase Its Proteolytic Activation Efficiency.Engineering Microbiology,3(4):100083.(#, Co-first author).
（18）Xiaoyu Liu, Zhe Chen, Xuyao Jiao, Xukai Jiang, Jicheng Qiu, Fuping You, Hongan Long, Hongzhi Cao, Casey C. Fowler,Xiang Gao* (2022) Molecular Insights into the Assembly and Functional Diversification of Typhoid.Toxin.mBio.13(1): e0191621.
（19）Lili Cao,Yujie Luo, Xuefei Guo,Shengde Liu, Siji Li, Junhong Li, Zeming Zhang, Yingchi Zhao, Qiao Zhang, Feng Gao, Xiong Ji,Xiang Gao, Yunfei Li*andFuping You*（2022）SAFA Facilitates Chromatin Opening of Immune Genes through Interacting with Nascent Antiviral RNAs.Plos Pathogens.18(6):e1010599.
（20）Jiao Pan,Weiyi Li,Jiahao Ni,Kun Wu, Iain Konigsberg, Caitlyn E. Rivera, Clayton Tincher,Colin Gregory, Xia Zhou, Thomas G. Doak, Heewook Lee, Yan Wang,Xiang Gao,Michael Lynch and Hongan Long*(2022).Rates of Mutations and Transcript Errors in the Foodborne Pathogen Salmonella enterica subsp. enterica.Molecular Biology and Evolution.39(4):msac081.
（21）Adaobi Ojiakor, Rachel N Gibbs, Zhe Chen,Xiang Gao, Casey C Fowler* (2022). The Evolutionary Diversification of theSalmonella artABToxin Locus.Front Microbiol.13:1016438.
（22）Jinghua Xu, Jiuqing Wang, Aijun Liu, Yanqing Zhang,Xiang Gao* (2021)Structural and Functional Analysis of SsaV Cytoplasmic Domainand Variable Linker States in the Context of the InvA-SsaV Chimeric Protein.Microbiology Spectrum.9(3):e01251-21.
（23）Huan Lian#, Kun Jiang#, Ming Tong#, Zhe Chen, Xiaoyu Liu, Jorge E. Galan*, andXiang Gao* (2021)The Salmonella Effector Protein SopD targets Rab8 GTPase to positively and negative regulate the inflammatory response.Nature Microbiology.6(3)658-671.(#, Co-first author).
（24）Kun Jiang#, Yan Zhang#, Zhe Chen#, Dalei Wu, Jun Cai andXiang Gao* (2020) Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin of Bacillus thuringiensis.Toxins.12: 1-15. (#, Co-first author).
（25）Peiyan Wang#, Siji Li#, Yingchi Zhao, Baohuan Zhang, Yunfei Li, Shengde Liu, Hongqiang Du, Lili Cao, Meiling Ou, Xiaohong Ye, Peng Li,Xiang Gao, Penghua Wang, Chunxia Jing, Feng Shao, Guang Yang* and Fuping You* (2019) The GRA15 Protein fromToxoplasma gondiiEnhances Host Defense Responses by Activating the Interferon Stimulator STING.J. Biol. Chem.294(45): 16494-16508.(#, Co-first author).
（26）Lili Cao#, Shengde Liu#, Yunfei Li, Guang Yang, Yujie Luo, Siji Li, Hongqiang Du, Yingchi Zhao, Dandan Wang, Jingxuan Chen, Zeming Zhang, Mo Li, Songying Ouyang,Xiang Gao, Yujie Sun, Zekun Wang, Long Yang, Rongtuan Lin, Penghua Wang and Fuping You* (2019) The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.Cell Host Microbe.26(3): 369-384.(#, Co-first author).
（27）Yiqiao Bao, Andrew A. Verdegaal, Brent W. Anderson, Natasha A. Barry, Jing He,Xiang Gao, Andrew L. Goodman (2021) A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria.mBio. 12(4): e00656-21.
（28）Xiang Gao,Lingquan Deng,Gabrielle Stack,Hai Yu,Xi Chen,Yuko Naito-Matsui,Ajit Varkiand Jorge E. Galan* (2017) Evolution of Host Adaptation in the SalmonellaTyphoid Toxin.Nature Microbiology.12, 1592-1599.
（29）Casey Fowler, Shu-Jung Chang,Xiang Gao, Tobias Geiger, Gabrielle Stack and Galan, Jorge E*（2017）Emerging Insights into the Biology of Typhoid Toxin.CurrOpin Microbiol.35: 70-77. (invited review paper).
2017年以前
(1)Stefania Spanò#,Xiang Gao#, Sebastian Hannemann#, María Lara-Tejero and Jorge E. Galan* (2016) A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.Cell Host Microbe.19(2):216-26. (#, Co-first author)
(2)Lingquan Deng#, Jeongmin Song#,Xiang Gao#, Jiawei Wang, Hai Yu, Xi Chen, Nissi Varki, Yuko Naito-Matsui, Jorge Galan* and Ajit Varki* (2014) Host Adaptation of a Bacterial Toxin from the Human PathogenSalmonellaTyphi.Cell.159(6):1290-9. (#, Co-first author)
(3)Jeongmin Song#,Xiang Gao#and Jorge E. Galan*(2013) Structure and Function of theSalmonellaTyphi Chimaeric A(2)B(5) Typhoid Toxin.Nature.499(7458):350-4. (#, Co-first author; Highlighted by F1000)
(4)Xiang Gao#, Lijun Zhou#, Xuyao Jiao, Feiran Lu, Chuangye Yan, Xin Zeng, Jiawei Wang and Yigong Shi* (2010) Mechanism of Substrate Recognition and Transport by an Amino Acid Antiporter.Nature.463, 828-832. (#, Co-first author)
(5)Xiang Gao#, Feiran Lu#, Lijun Zhou#, Shangyu Dang, Linfeng Sun, Xiaochun Li, Jiawei Wang and Yigong Shi* (2009) Structure and Mechanism of an Amino Acid Antiporter.Science.324, 1565-1568. (#, Co-first author)
