教育背景
博士 起止时间：1994-1997 毕业院校：山东大学 专业：微生物学
硕士 起止时间：1991-1994 毕业院校：山东大学 专业：微生物学
学士 起止时间：1987-1991 毕业院校：山东大学 专业：微生物学
工作经历
2025-今 山东大学微生物改造技术全国重点实验室 教授
1997-2024 山东大学微生物技术国家重点实验室 教授
2006 美国加州大学洛杉矶分校 医学院 访问学者
2002-2003 英国谢菲尔德大学 生化与分子生物学系 访问学者
研究方向
1. 生物质资源的转化利用及相关酶的分子催化机制
2. 高等真菌生物活性物质的发掘和综合利用
3. 用于控制耐药菌感染的新型噬菌体裂解酶的开发和分子改造
代表性论文
近年作为责任作者的代表性论文：
1.Wenxia Song, Shaoqi Geng, Qingsheng Qi andXuemei Lu *，UgdIs Involved in the Synthesis of Glycans of Glycoprotein and LPSandIs Important for Cellulose Degradation in Cytophaga hutchinsonii，Microorganisms2025,13(2),
2. Yutao Zhong1, Jinhong Gu, Changyu Shang, Jingyu Deng, Yuhang Liu, Zhiyong Cui*,Xuemei Lu*, Qingsheng Qi*，Sustainable succinic acid production from lignocellulosic hydrolysates by engineered strains of Yarrowia lipolytica at low pH，Bioresource technology，2024.9/1-8/6138.
3. Shuhang Zhang1, Kangshu Wen, Wenxia Song, Qingbin Li, Qingsheng Qi, andXuemei Lu *，Enhancing Lysostaphin Thermostability and Utilizing Lysostaphin‐Producing Probiotics to Combat Staphylococcus aureus in Milk. Journal of Food Biochemistry，2024.8/1-12/8371
4.Yan chang, Qingbin Li, Shuhang Zhang, Qing Zhang, Yuqing Liu, Qingsheng Qi, andXuemei Lu*. Identification and Molecular Modification ofStaphylococcus aureusBacteriophage Lysin LysDZ25.ACS Infectious Diseases, 2023, 9(3): 497-506.
5.Shuai Ma, Feiyu Wang, Zhang Xuejing,Qiao Liping,Guo Xueping,Xuemei Lu *,Qingsheng Qi *. Repurposing endogenous type II CRISPR‐Cas9 system for genome editing inStreptococcus thermophilus[J].Biotechnology and Bioengineering, 2023.1-8
6.Shuai Ma, Tianyuan Su,Xuemei Lu *,Qingsheng Qi *. Bacterial genome reduction for optimal chassis of synthetic biology: a review. Critical Reviews inBiotechnology, 2023: 1-14.
7.Some novel features of strong promoters discovered inCytophaga hutchinsonii,Appl Microbiol Biotechnol2022,106, 2529–2540.
8.Shuai Ma, Tianyuan Su, Jinming Liu, Qian Wang, Quanfeng Liang,Xuemei Lu*, QingshengQi*. Random genome reduction coupled with polyhydroxybutyrate biosynthesis to facilitate its accumulation inEscherichia coli.Front Bioeng Biotechnol. 2022.Vol. 10 978211.
9.Shuai Ma, Tianyuan Su, Jinming Liu, Xuemei Lu*, Qingsheng Qi*. Reduction of the Bacterial Genome by Transposon-Mediated Random Deletion.ACS synthetic biology,2022,vol. 11,2 : 668-677.
10.Wenxia Song,Xueke Zhuang,Yahong Tan,Qingsheng Qi,XuemeiLu*.The type IX secretion system: Insights into its function and connection to glycosylation inCytophaga hutchinsonii.Engineering Microbiology，2022，Volume 2, Issue 3.
11.Shuaishuai Xie, Qing Huang, Rong Tan, Weican Zhang, Qingsheng Qi,Xuemei Lu*.Glycosyltransferase-Related Protein GtrA Is Essential for Localization of Type IX Secretion System Cargo Protein Cellulase Cel9A and Affects Cellulose Degradation in Cytophaga hutchinsonii.Applied and environmental microbiology, 2022，e0107622. 5 Oct. 88(20)
12.Shuaishuai Xie, Yahong Tan, Wenxia Song, Weican Zhang, Qingsheng Qi,Xuemei Lu*.N-Glycosylation of a Cargo Protein C-Terminal Domain Recognized by the Type IX Secretion System in Cytophaga hutchinsonii Affects Protein Secretion and Localization.Applied and environmental microbiology 2022，vol. 88,1: e0160621.
13.Yingbo Yuan, Qingbin Li, Shuhang Zhang, Jinhong Gu, Guangtao Huang, Qingsheng Qi,Xuemei Lu*.Enhancing thermal stability and lytic activity of phage lysin PlyAB1 from Acinetobacter baumannii.Biotechnology and bioengineering,2022,vol. 119,10: 2731-2742.
14.Shuhang Zhang, Yan Chang, Qing Zhang, Yingbo Yuan, Qingsheng Qi,Xuemei Lu*.Characterization of Salmonella endolysin XFII produced by recombinant Escherichia coli and its application combined with chitosan in lysing Gram-negative bacteria.Microbial cell factories,2022.vol. 21,1 171. 23 Aug.
15.Yahong Tan , Wenxia Song , Lijuan Gao, Weican Zhang ,andXuemei Lu*，Cytophaga hutchinsoniichu_2177, encoding the O-antigen ligase, is essential for cellulose degradation，Journal of Microbiology,2022,Vol. 60, No. 4, pp. 364–374
16.Lijuan Gao, Yaru Su, Wenxia Song, Weican Zhang,Xuemei Lu*
T9SS Substrate Involved in Crystalline Cellulose Degradation by Affecting Crucial Cellulose Binding Proteins inCytophaga hutchinsonii,Appl. Environ. Microbiol.,2022,Vol 88(2): e01837-21.
17.Lijuan Gao, Yahong Tan, Weican Zhang, Qingsheng Qi andXuemei Lu*, Cytophaga hutchinsoniiSprA and SprT are essential components of the type IX secretion system required for Ca2+ acquisition, cellulose degradation, and cell motility,Frontiers in Microbiology, 2021. 12: p. 628555.
18. Dong Zhao, Wenxia Song, Sen Wang, Weican Zhang, Yue Zhao,Xuemei Lu*, Identification of the Type IX Secretion System Component, PorV (CHU_3238), Involved in Secretion and Localizationof Proteins inCytophaga hutchinsonii,Frontiers in Microbiology, 2021，Vol12, doi: 10.3389/fmicb..742673,
获奖情况
1.国家科技奖自然科学二等奖（主要参与人）
2.山东省科技进步奖二等奖 （第一位）
3.山东省高等学校优秀科研成果奖二等奖（第一位）
4.山东大学教育拓展优秀名师
所获专利
1.一种溶葡萄球菌酶变体及其在益生菌中表达的方法及其应用,专利号：ZL 2023 1 0295225.3
2.具有体外裂解活性的耐热耐富营养沙门氏菌宽谱裂解酶及其制备与应用,专利号：ZL 2021 1 1532742.5
3.一种溶葡萄球菌酶变体及其制备方法和应用；专利号：ZL 2022 1 1032377.6
4.一株产γ-癸内酯的滴孔菌及其应用,专利号：ZL 2017 1 0486577.1
5.一株产三萜类化合物的滴孔菌及其应用,专利号：ZL 2017 1 0486576.7
6.一种制备交联剩余污泥重金属吸附剂的方法，专利号：ZL 2014 1 0018162.8
7.一种多功能纤维素酶及其表达基因与应用，专利号：ZL 201210439217.3
8.大孔交联海藻酸钠凝胶球的制备方法，专利号：ZL 2011 1 0109497.7
9.产β-1，3-葡聚糖酶的微生物及应用,专利号：ZL 2009 1 0020307.7
