代表论文
I.转录因子靶标蛋白的结构功能研究和靶向分子发现领域
12. Diao X, Shang Q, Guo M, Huang Y, Zhang M, Chen X, Liang Y, Sun X, Zhou F, Zhuang J, Liu SJ, Vogel CFA, Rastinejad F,Wu D. Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex.Nat Commun.2025, 16: 1282.（独立通讯作者）
11. Zhuang J, Shang Q, Rastinejad F*,Wu D*. Decoding allosteric control in hypoxia-inducible factors.J Mol Biol.2024, 436: 168352.（*共同通讯作者）
10. Li P, Tian Y, Shang Q, Tang C, Hou Z, Li Y, Cao L, Xue S, Bian J, Luo C,Wu D*, Li Z*, Ding H*. Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT.Bioorg Chem.2023,139: 106676.（*共同通讯作者）
9. Song W, Zhuang J, Zhang N, Ren X, Xu W, Guo M, Diao X, Liu C, Jin J,Wu D*, Zhang Y*. SAR study of 1,2-benzisothiazole dioxide compounds that agonize HIF-2 stabilization and EPO production.Bioorg Med Chem. 2023, 77: 117041.（*共同通讯作者）
8. Sun X, Jing L, Li F, Zhang M, Diao X, Zhuang J, Rastinejad F,Wu D. Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.Proc Natl Acad Sci USA. 2022, 119: e2208804119.（独立通讯作者）
7. Ren X, Diao X, Zhuang J*,Wu D*. Structural basis for the allosteric inhibition of hypoxia-inducible factor 2 by belzutifan.Mol Pharmacol.2022, 102: 240-247.（*共同通讯作者）
6. Diao X, Ye F, Zhang M, Ren X, Tian X, Lu J, Sun X, Hou Z, Chen X, Li F, Zhuang J, Ding H, Peng C, Rastinejad F*, Luo C*,Wu D*. Identification of oleoylethanolamide as an endogenous ligand for HIF-3α.Nat Commun.2022, 13: 2529.（*共同通讯作者）
5. Zhuang J, Liu Q,Wu D*, Tie L*. Current strategies and progress for targeting the "undruggable" transcription factors.Acta Pharmacol Sin. 2022, 43: 2474-2481.（*共同通讯作者）
4. Li F, Song C, Zhang Y,Wu D. Structural overview and perspectives of the nuclear receptors, a major family as the direct targets for small-molecule drugs.Acta Biochim Biophys Sin (Shanghai). 2022, 54: 12-24.（独立通讯作者）[封面文章]
3.Wu D*, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim Y, Khorasanizadeh S, Rastinejad F*. Bidirectional modulation of HIF-2 activity through chemical ligands.Nat Chem Biol.2019, 15: 367-376. （*共同通讯作者）[获得F1000Prime推荐]
2. Smith SH, Jayawickreme C, Rickard DJ, Nicodeme E, Bui T, Simmons C, Coquery CM, Neil J, Pryor WM, Mayhew D, Rajpal DK, Creech K, Furst S, Lee J,Wu D, Rastinejad F, Willson TM, Viviani F, Morris DC, Moore JT, Cote-Sierra J. Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.J Invest Dermatol.2017, 137: 2110-2119.
1.Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors.Nature.2015, 524: 303-308.（独立第一作者）[在Nature同期News&Views栏目中被特别介绍，并获得F1000Prime推荐]
II.其他药物靶标蛋白的结构功能研究和靶向分子发现领域
5. Li F*, Zhang M, Liu C, Cheng J, Yang Y, Peng X, Li Z, Cai W, Yu H, Wu J, Guo Y, Geng H, Fa Y, Zhang Y,Wu D*, Yin Y*. De novo discovery of a molecular glue-like macrocyclic peptide that induces MCL1 homodimerization.Proc Natl Acad Sci USA. 2025, 122: e2426006122.（*共同通讯作者）
4.LiuJ, Sun X, Zhuang J, Liu Z, Xu C,Wu D*, Wu C*. Biphenyl-dihydrothiazole-cyclized peptide libraries for peptide ligand and drug discovery.Sci. China Chem.2025, 68, https://doi.org/10.1007/s11426-024-2291-x.（*共同通讯作者）
3. Cui J, Liu X, Shang Q, Sun S, Chen S, Dong J, Zhu Y, Liu L, Xia Y, Wang Y, Xiang L, Fan B, Zhan J, Zhou Y, Chen P, Zhao R, Liu X, Xing N*,Wu D*, Shi B*, Zou Y*. Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance.Mol Cancer.2024, 23: 86.（*共同通讯作者）
2. Li F*, Liu J, Liu C, Liu Z, Peng X, Huang Y, Chen X, Sun X, Wang S, Chen W, Xiong D, Diao X, Wang S, Zhuang J, Wu C*,Wu D*. Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy.Nat Commun.2024, 15: 1476.（*共同通讯作者）
1.Xu M, Xu HH, Lin Y, Sun X, Wang LJ, Fang ZP, Su XH, Liang XJ, Hu Y, Liu ZM, Cheng Y, Wei Y, Li J, Li L, Liu HJ, Cheng Z, Tang N, Peng C, Li T, Liu T, Qiao L,Wu D, Ding YQ, Zhou WJ. LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis.Cell. 2019, 178: 1478-1492.[获得F1000Prime推荐]
III.生物合成相关酶的结构解析和催化机理研究领域
4. Chen Y, Jing L, Peng M, Cai C, Shi J, Ge W, Liu Y, Shang Z, Ma J*,Wu D*, Ju J*. Enzymatic insights into the unusual formation of benzolactone and benzopyran in the biosynthesis of spiromarmycin.ACS Catal.2025, 15: 2809-2821.（*共同通讯作者）
3. Chen X, Zhao H, Wang C, Hamed M, Shang Q, Yang Y, Diao X, Sun X, Hu W, Jiang X, Zhang Y, Hirsch AKH,Wu D*, Zhuang J*. Two natural compounds as potential inhibitors against theHelicobacter pyloriandAcinetobacter baumanniiIspD enzymes.Int J Antimicrob Agents.2024, 63: 107160.（*共同通讯作者）
2. Wang X, Chen X, Wang ZJ, Zhuang M, Zhong L, Fu C, Garcia R, Müller R, Zhang Y, Yan J*,Wu D*, Huo L*. Discovery and characterization of a myxobacterial lanthipeptide with unique biosynthetic features and anti-inflammatory activity.J Am Chem Soc.2023, 145: 16924-16937.（*共同通讯作者）
1.Zhong L, Diao X, Zhang N, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y*,Wu D*, Bian X*. Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.Nat Commun.2021, 12: 296.（*共同通讯作者）[入选“有机化学和化学生物学”领域焦点论文]
