1. Fengwei Li#*, Mengmeng Zhang#, Chao Liu#, Jie Cheng, Yawen Yang, Xiangda Peng, Zhifeng Li, Wenfeng Cai, Haipeng Yu, Junjie Wu, Yuyu Guo, Hongkun Geng, Yun Fa, Youming Zhang, Dalei Wu*,Yizhen Yin*.De novo discovery of a molecular glue-like macrocyclic peptide that induces MCL1 homodimerization.Proc. Natl. Acad Sci U S A.2025, 122(13): e2426006122.
2. Yahong Tan＃, Jinyue Yang＃, Min Wang＃, Qi Peng, Yongqi Li, Lifeng Fu, Mengmeng Zhang, Jiang Wu, Guanya Yang, Christopher John Hipolito, Youming Zhang, Jianxun Qi, Yi Shi*, andYizhen Yin*.De NovoDiscovery of a Noncovalent Cell-Penetrating BicyclicPeptide Inhibitor Targeting SARS-CoV‑2 Main Protease.J. Med. Chem.2024, 67, 20258–20274.
3. Junjie Wu, Yuchan Wang, Wenfeng Cai, Danyan Chen, Xiangda Peng, Huilei Dong, Jinjing Li, Hongtan Liu, Shuting Shi, Sen Tang, Zhifeng Li, Haiyan Sui, Yan Wang, Chuanliu Wu, Youming Zhang,* Xinmiao Fu,* andYizhen Yin*.Ribosomal Translation of Fluorinated Non-Canonical Amino Acids for De Novo Biologically Active Fluorinated Macrocyclic Peptides.Chem. Sci.2024, 15, 13889–13898.
4. Lulu Song, Hongtan Liu, Maolin Li, Yawen Yang, Huilei Dong, Jinjing Li, Jiaqi Shao, Lixu Zhi, Hao Sun, Zhifeng Li, Haiyan Sui, Youming Zhang, Chuanliu Wu*, andYizhen Yin*. Ribosomal incorporation of lithocholic acid into peptides for the de novo discovery of peptide-lithocholic acid hybrid macrocyclic peptides.ACS Chem. Biol.2024, 19, 7, 1440–1446.
5. Silong Zhai, Yahong Tan, Cheng Zhu, Chengyun Zhang, Yan Gao, Qingyi Mao, Youming Zhang, Hongliang Duan*, and Yizhen Yin*. PepExplainer: an explainable deep learning model for selection-based macrocyclic peptide bioactivity prediction and optimization.Eur. J. Med. Chem.2024, 275, 116628.
6.Yizhen Yin*, Christopher John Hipolito*. Recent advances in non-standard macrocyclic peptide ligand discovery using mRNA display.Isr. J. Chem.2024, e202300167.
7. Silong Zhai＃, Yahong Tan＃, Chengyun Zhang, Christopher John Hipolito, Lulu Song, Cheng Zhu, Youming Zhang, Hongliang Duan*, andYizhen Yin*. PepScaf: Harnessing Machine Learning with In Vitro Selection toward De Novo Macrocyclic Peptides against IL-17C/IL-17RE Interaction.J.Med. Chem.2023, 66, 16, 11187–11200.
8. Huilei Dong＃, Jinjing Li＃, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang,Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporationof Noncanonical Disulfide-Directing Motifs for the Development of MulticyclicPeptide Libraries.J. Am. Chem. Soc.2022, 144, 5116–5125.
9. Daisuke Hazama＃,Yizhen Yin＃, Yoji Murata*, Makoto Matsuda, TakeshiOkamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto,Yuka Kakuchi, Yasuyuki Saito, Takenori Kotani, Yoshihiro Nishimura, AtsushiNakagawa, Hiroaki Suga*, Takashi Matozaki*. Macrocyclic Peptide-MediatedBlockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy.Cell Chem. Biol.2020, 27, 1181-1191. (Co-first author)
10.Yizhen Yin, Nobuaki Ochi, Timothy W. Craven, David Baker, Nagio Takigawa,Hiroaki Suga*. De novo carborane-containing macrocyclic peptides targetinghuman EGFR.J. Am. Chem. Soc.2019, 141, 19193–19197.
11.Yizhen Yin＃, Qianran Fei＃, Weidong Liu, Zhuoru Li, Hiroaki Suga*, Chuanliu Wu*.Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic andTricyclic Peptide Scaffolds Primed by Selenoether Formation.Angew. Chem. Int.Edit.2019, 58, 4880-4885.
12. Alex Vinogradov,Yizhen Yin, Hiroaki Suga*. Macrocyclic peptides as drugcandidates: recent progress and remaining challenges.J. Am. Chem. Soc.2019,141, 4167-4181.
13. Sayaka Imanishi, Takayuki Katoh,Yizhen Yin, Mituhiro Yamada, Marina Kawai,
Hiroaki Suga*. In Vitro Selection of Macrocyclic D/L-Hybrid Peptides against
Human EGFR.J. Am. Chem. Soc.2021, 143, 5680–5684.
14. Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura,Kyoko Matoba, Yumi Sano, Rumit Maini,Yizhen Yin, Katsuya Sakai, TakaoArimori, Kunio Matsumoto, Hiroaki Suga*, Junichi Takagi*. Lasso-grafting ofmacrocyclic peptide pharmacophores yields multi-functional proteins.Nat.Commun.2021, 12, 1543.
15. Junjie Wu, Mengmeng Zhang, Lulu Song, Yahong Tan, Yosuke Taniguchi, Christopher John Hipolito, Youming Zhang*,Yizhen Yin*.Implications of N7-hydrogen and C8-keto on the base pairing, mutagenic potential and repair of 8-oxo-2′-deoxy-adenosine: Investigation by nucleotide analogues.Bioorg. Chem.2022, 127, 106029.
16. Changsheng Wu＃*,Yizhen Yin＃, Lele Zhu, Youming Zhang, Yue-Zhong Li*.Metagenomic sequencing-driven multidisciplinary approaches to shed light on theuntapped microbial natural products.Drug Discov. Today2022, 27, 730–742.
17. Yahong Tan＃, Junjie Wu＃, Lulu Song, Mengmeng Zhang, Christopher JohnHipolito, Changsheng Wu, Siyuan Wang*, Youming Zhang,Yizhen Yin*.Merging the Versatile Functionalities of Boronic Acid with Peptides.Int. J. Mol.Sci.2021, 22, 12958.
18. Jia-Qi Hu, Jing-Jing Wang, Yue-Lan Li, Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-JuLi, Tao Shen,Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, ChangshengWu*. Combining NMR-Based Metabolic Profiling and Genome Mining for theAccelerated Discovery of Archangiumide, an Allenic Macrolide from theMyxobacterium Archangium violaceum SDU8.Org. Lett.2021, 23,2114–2119.
19.Yizhen Yin, Fener Chen*. Targeting human MutT homolog 1 (MTH1) for cancer
eradication: current progress and perspectives.Acta Pharm. Sin. B, 2020, 10,2259–2271.
20.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Effects of8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNApolymerases and cell proliferation.Bioorg. Med. Chem.2016, 24,3856-3861.
21.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Inhibitory Effect of8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Activities.ChemBioChem2016, 17, 566-569.
22.Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Recognition and excisionproperties of 8-halogenated-7-deaza-2'-deoxyguanosine as8-oxo-2'-deoxyguanosine analogues and Fpg and hOGG1 inhibitors.ChemBioChem2015, 16, 1190-1198.
23.Yizhen Yin, Yosuke Taniguchi*, Shigeki Sasaki*. Synthesis of 8-Halogenated-7-deaza-2'-deoxyguanosine as an 8-Oxo-2'-deoxyguanosine Analogue andEvaluation of its Base Pairing Properties.Tetrahedron2014, 70, 2040-2047.
24.Yizhen Yin, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*. Recoverable Pd/C
catalyst mediated dehydrogenation of sterols and an improved synthesis of1α-hydroxydehydroepiandrosterone.Steroids2012, 77, 1419–1422.
25.Yizhen Yin, Jian-Ping Li, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*.Advances in the Synthesis of A-Ring 1,7-Enyne Synthons for Active Vitamin D3Analogues.Curr. Org. Synth.2011, 8, 374-392.
26. Bing-Lei Gao, Cheng-Mei Zhang,Yi-Zhen Yin, Long-Qian Tang, Zhao-Peng Liu*.Design and synthesis of potent HIV-1 protease inhibitors incorporatinghydroxyprolinamides as novel P2 ligands.Bioorg. Med. Chem.Lett.2011, 21, 3730-3733.
