山东省泰山学者青年人才

张贞干

研究员
个人简介 科研项目 学术论文 其他介绍

教育背景:

博士:2013.8 – 2019.4,美国伊利诺伊大学厄巴纳香槟分校,化学生物学,导师:Wilfred van der Donk

学士:2009.9 – 2013.6,武汉大学,化学基地班


工作经历:

2019.5 – 2024.4,美国麻省理工学院,博士后,合作导师:Christopher Voigt

2024.6至今, 山东大学微生物技术国家重点实验室,研究员


研究方向:

1.合成生物学技术的开发与应用

2.微生物天然产物的挖掘与表征

3.天然产物结构改造工具的开发与应用

主要项目:

山东大学齐鲁青年学者学科建设经费,2024 - 2029,在研,主持

代表性论文:

1.Glassey, E.#;Zhang, Z.#;King, A. M.; Niquille, D. L.; Voigt, C. A.Computational design of enzyme modified peptides.Nat. Chem.2024(accepted).

2.King, A. M.#;Zhang, Z.#;Glassey, E.;Siuti P.; Clardy J.;Voigt, C. A. Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra.Nat Microbiol.2023,8, 2420–2434.

3.Zhang, Z.; van der Donk, W. A.Nonribosomal Peptide Extension by a Peptide Amino-Acyl tRNA Ligase.J. Am. Chem. Soc.2019, 141, 19625–19633.

4.Zhang, Z.; Mahanta, N.; Hudson, G. A.; Mitchell, D. A.; van der Donk, W. A., Mechanism of a Class C RadicalS-Adenosyl-L-methionine Thiazole Methyl Transferase.J. Am. Chem. Soc.2017,139, 18623-18631.

5.Zhang, Z.; Hudson, G. A.; Mahanta, N.; Tietz, J. I.; van der Donk, W. A.; Mitchell, D. A., Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin.J. Am. Chem. Soc.2016,138, 15511-15514.

6.Hudson, G. A.#;Zhang, Z.#; Tietz, J. I.; Mitchell, D. A.; van der Donk, W. A., In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin.J. Am. Chem. Soc.2015,137, 16012-16015.

7.Ting, C. P.; Funk, M. A.; Halaby, S. L.;Zhang, Z.; Gonen, T.; van der Donk, W. A. Use of a scaffold peptide in the biosynthesis of amino acid–derived natural products.Science2019,365, 280-284.

8.King, A. M.; Anderson, D. A.; Glassey, E.; Segall-Shapiro, T. H.;Zhang, Z.; Niquille, D. L.; Embree, A. C.; Pratt, K.; Williams, T. L.; Gordon, D. B.; Voigt, C. A. Selection for constrained peptides that bind to a single target protein.Nat. Commun.2021, 12 (1), 1-12

9.Cogan, D. P.; Hudson, G. A.;Zhang, Z.; Pogorelov, T. V.; van der Donk, W. A.; Mitchell, D. A.; Nair, S. K., Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.Proc. Natl. Acad. Sci. USA.2017,114, 12928-12933.

10.Mahanta, N.;Zhang, Z.; Hudson, G. A.; van der Donk, W. A.; Mitchell, D. A., Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine ThiazoleC-Methyltransferase in Thiomuracin Biosynthesis.J. Am. Chem. Soc.2017,139, 4310-4313.

11.Glassey, E;King, A. M.; Anderson, D. A.;Zhang, Z.; Voigt, C. A.Functional expression of diverse post-translational peptide-modifying enzymes inEscherichia coliunder uniform expression and purification conditions.PLoS One. 2022, 17(9): e0266488.

12.Yuan, L.;Zhang, Z.; Xu, X.; Zhou, X. Chemical labeling of 5-iodo-2’-deoxyuridine with 4-ethynyl-N-ethyl-1,8-naphthalimide using copper-free Sonogashira cross-coupling in aqueous medium.Synth. Commun.2014, 44, 1007-1011

13.Tian, T.; Xiao, H.;Zhang, Z.; Long, Y.; Peng, S.; Wang, S.; Zhou, X.; Liu, S.; Zhou, X., Sensitive and convenient detection of microRNAs based on cascade amplification by catalytic DNAzymes.Chem. Eur. J.2013,19, 92-95.

14.Yuan, L.; Tian, T.; Chen, Y.; Yan, S.; Xing, X.;Zhang, Z.; Zhai, Q.; Xu, L.; Wang, S.; Weng, X.; Yuan, B.; Feng, Y.; Zhou, X., Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy.Sci. Rep.2013,3, 1811.

获奖情况

1.2018年,国家优秀自费留学生奖学金

2.2017年,伊利诺伊大学厄巴纳香槟分校,Pines Graduate Fellowship

3.2015-2017年 ,伊利诺伊大学厄巴纳香槟分校,化学院Marvel Fellowship