教育背景
博士,2009/09-2014/03,德国慕尼黑大学,微生物学,博士
硕士,2006/09-2009/07,山东大学,微生物技术国家重点实验室,硕士
学士,2002/09-2006/07,山东大学,生命科学学院基地班,学士
工作经历
2019/03-至今,山东大学微生物技术研究院,助理研究员
2016/08-2019/02,中国科学院海洋研究所,师资博后
主要研究方向
1.海洋多糖生物质资源降解微生物的挖掘和优质微生物资源库的构建;
2.海洋多糖生物质资源微生物转化的作用机理和调控机制;
3.海洋多糖生物质资源的绿色高效转化。
科研项目
1.2025/10-2028/9,溶藻弧菌多酶系统高效降解褐藻胶的分子机制,山东省自然科学基金面上项目,主持;
2.2025/12-2026/6,油气生物学知识库和专家问答模型构建服务,中科院攻坚项目,主持;
3.2025/10-2026/10,酱油发酵过程中米曲霉酶系组成解析,横向项目,主持;
4.2024/8-2026/8,南美白对虾养殖水体有毒无机氮积累的关键因素及其无毒化功能微生物的筛选,横向项目,主持;
5.2023/9-2024/9,大豆难降解蛋白的研究,横向项目,主持;
6.2023/01-2025/12,铁摄取调控因子Fur参与鳗弧菌致病的分子机制研究,山东省自然科学基金面上项目,主持;
7.2023/08-2025/12,石斑鱼养殖病原菌快速检测分析研究,横向项目,主持;
8.2022/06-2023/12,大菱鲆养殖病原菌快速检测分析研究,横向项目,主持;
9.2019/03-2021/12,趋磁细菌反硝化途径的生物工程改造,山东大学基本科研业务费,主持;
10.2018/01-2020/12,硝酸盐还原酶Nap影响磁小体生物矿化的机制研究,国家自然科学基金青年基金项目,主持;
11.2018/01-2019/12,铁运输系统Fhu、Feo和Fbp在鳗弧菌生长和致病过程的作用和机制研究,青岛市科技计划应用基础研究青年专项,主持;
12.2017/08-2018/12,铁运输系统Feo在鳗弧菌生长和致病过程的作用和机制研究,山东省博士后创新基金项目,主持;
13.2016/12-2018/08,硝酸盐还原酶Nap参与磁小体生物矿化的机制研究,中国博士后科学基金面上资助项目,主持;
14.2016/08-2018/07,中国科学院“博士后国际交流计划”引进项目,主持。
学术论文(第一或通讯作者*论文)
1.Li X, Zhang L, Tang Y, Li Y, Wu X,Li YJ*,Wang L: A key loop in the catalytic pocket of the PL17 family of alginate lyases determines minimal substrate recognition.J Biol Chem 2025, 301(8).
2.Li Y, Deng Y,Li YJ*,Wang L: Identification and characterization of a novel alginate lyase VSAly7C with potential application for alginate di- and tri-saccharide preparation.J Agr Food Chem 2025, 73(19):11855-11865.
3.Tang Y, Song Z, Xu X,Li YJ*, Wang L: Insights into the mechanism of substrate specificity in a novel PL15_3 subfamily oligo-alginate lyase VBAly15A.Appl Environ Microbiol 2025, 91(3):e0235124.
4.Li YJ, Yu X, Li P, Li X, Wang L: Characterization of theVibrio anguillarumVaRyhB regulon and role in pathogenesis.Front Cell Infect Microbiol 2024, 14:1531176.
5.Li YJ, Yu X, Li P, Li X, Wang L: Characterization of the ferric uptake regulator VaFur regulon and its role inVibrio anguillarumpathogenesis.Appl Environ Microbiol 2024:e0150824.
6.Zhang X, Tang Y, Gao F, Xu X, Chen G,Li YJ*, Wang L: Low-cost and efficient strategy for brown algal hydrolysis: Combination of alginate lyase and cellulase.Bioresour Technol 2024:130481.
7.Du M, Li X, Qi W,Li YJ*, Wang L: Identification and characterization of a critical loop for the high activity of alginate lyase VaAly2 from the PL7_5 subfamily.Front Microbiol 2023, 14:1333597.
8.Cao WR, Yu XR, Sun YY, Jiang MY, Xu XD,Li YJ*:Ornithinimicrobium laminariaesp. nov., isolated from the kelpLaminaria japonica.Int J Syst Evol Microbiol 2022, 72(1).
9.Cao WR, Li X, Sun YY, Jiang MY, Xu XD,Li YJ*:Shewanella nanhaiensissp. nov., a marine bacterium isolated from sediment of South China Sea, and emended descriptions ofShewanella woodyi, Shewanella hanedaiandShewanella canadensis.Int J Syst Evol Microbiol 2021, 71(12).
10.Zhang LZ, Li X, Zhang XY,Li YJ*, Wang LS: Bacterial alginate metabolism: an important pathway for bioconversion of brown algae.Biotechnol Biofuels 2021, 14(1).
11.Li YJ*: Redox control of magnetosome biomineralization.J Oceanol Limnol 2021, 39(6):2070-2081.
12.Cao WR, Zhang LZ, Hu YH, Jiang MY,Li YJ*:Salinimicrobium nanhaiensesp. nov. andSalinimicrobium oceanisp. nov., two novel species of the familyFlavobacteriaceaeisolated from the South China Sea.Int J Syst Evol Microbiol 2020, 70(10):5263-5270.
13.Cao WR, Wang LS, Saren GW, Yu XK*,Li YJ*: Variable microbial communities in the non-hydrothermal sediments of the Mid-Okinawa Trough.Geomicrobiol J 2020, 37(8):774-782.
14.Li YJ, Cao W, Wang Y, Ma Q: Microbial diversity in the sediments of the southern Mariana Trench.J Oceanol Limnol 2019, 37(3):1024-1029.
15.Li YJ, Ma QJ: Iron acquisition strategies ofVibrio anguillarum.Front Cellular Infect Microbiol 2017, 7:342.
16.Li YJ, Sabaty M, Borg S, Silva KT, Pignol D, Schüler D: The oxygen sensor MgFnr controls magnetite biomineralization by regulation of denitrification inMagnetospirillum gryphiswaldense.BMC Microbiol 2014, 14:153.
17.Li YJ, Raschdorf O, Silva KT, Schüler D: The terminal oxidasecbb3functions in redox control of magnetite biomineralization inMagnetospirillum gryphiswaldense.J Bacteriol 2014, 196(14):2552-2562.(Recommended by Faculty of 1000 and selected for F1000Prime)
18.Li YJ, Bali S, Borg S, Katzmann E, Ferguson SJ, Schüler D: Cytochromecd1nitrite reductase NirS is involved in anaerobic magnetite biomineralization inMagnetospirillum gryphiswaldenseand requires NirN for properd1heme assembly.J Bacteriol 2013, 195(18):4297-4309.
19.Li YJ, Katzmann E, Borg S, Schüler D: The periplasmic nitrate reductase Nap is required for anaerobic growth and involved in redox control of magnetite biomineralization inMagnetospirillum gryphiswaldense.J Bacteriol 2012, 194(18):4847-4856.
20.李雪,吴秀芸,李颖杰*,王禄山. 海洋褐藻多糖复杂结构、降解酶系以及生物学功能的研究进展. 生物化学与生物物理进展.
21.于欣冉,李颖杰*,陈冠军,王禄山. 铁摄取调节蛋白Fur功能和作用模式的研究进展. 生物化学与生物物理进展,2021,48(6):618-636.
22.孔天翔,赵依昕,杜婧,李颖杰*. 细菌六型分泌系统的研究进展. 生物化学与生物物理进展,2020,47(12):1273-1284.
教改论文(第一或通讯作者论文)
1.李颖杰*,郭婷婷,王明钰,武大雷,高翔,王禄山*. 基于综合能力培养的“结构生物学”教学改革. 生物化学与生物物理进展, 2024, 51 (11): 3046-3053.