教育背景
2013/09–2018/06山东大学生命科学学院微生物学专业博士
2009/09–2013/07青岛农业大学生命科学学院生物技术专业学士
工作经历
2022/02–至今山东大学微生物技术研究院助理研究员
2018/06–2022/02山东大学微生物技术研究院博士后
研究方向
生物质多糖资源的生物转化
糖苷水解酶的机制探究与理性设计
科研项目
2022.01–2024.12嗜热几丁质酶SsChi18A持续性催化的分子机制研究,国家自然科学基金青年项目，32100022，主持
2020.10–2022.10啤酒麦糟结构分析及木聚糖酶解转化工艺，国重室开放课题，K202005，主持
2021.01–2022.12高温碱性木聚糖酶的理性设计，国重室开放课题，GZKF202020，主持
学术论文
1.Xiuyun Wu, Zelu Shi, Wenya Tian, Mengyu Liu, Shuxia Huang, Xinli Liu, Hua Yin* andLushan Wang*, A thermostable and CBM2-linked GH10 xylanase fromThermobifida fuscafor paper bleaching.Front. Bioeng. Biotechnol.2022, 10: 939550.
2.Xiuyun Wu, Shu Zhang, Sha Zhao, Lin Dai, Shuxia Huang, Xinli Liu, Junhong Yu,* and Lushan Wang*.Functional specificity of three α‑arabinofuranosidases from different glycoside hydrolase families inAspergillus nigerAn76.J. Agric. Food Chem.2022, 70:5039−5048.
3.Shu Zhang, Sha Zhao, Shang Weihao, Zijuan Yan,Xiuyun Wu*, Yingjie Li, Guanjun Chen, Xinli Liu, Lushan Wang. Synergistic mechanism of GH11 xylanases with different action modes fromAspergillus nigerAn76.Biotechnol Biofuels, 2021, 14(1): 118.
4.Xiuyun Wu, Shu Zhang, Qun Zhang, Yue Zhao, Guanjun Chen, Weihua Guo and Lushan Wang*.The contribution of specific subsites to catalytic activities in active site architecture of GH11 xylanase.Appl Microbiol Biotechnol. 2020,104: 8735–8745.
5.Xiuyun Wu, Qun Zhang, Lanzeng Zhang, Shijia Liu, Guanjun Chen, Huaiqiang Zhang and Lushan Wang*. Insights into the role of exposed surface charged residues in the alkali-tolerance of GH11 xylanase.Front Microbiol,2020,11: 872.
6.Xiuyun Wu, Zhennan Tian, Xukai Jiang, Qun Zhang, Lushan Wang*. Enhancement in catalytic activity ofAspergillus nigerXynB by selective site-directed mutagenesis of active site amino acids.Appl Microbiol Biotechnol, 2018, 102:249–260.
7.赵沙，颜子娟，张舒，余俊红，吴秀芸*，王禄山等.细菌几丁质酶结构、功能及分子设计的研究进展.生物化学与生物物理进展，2022，49(07):1179-1191.
8.张舒，赵越，陈冠军，余俊红，吴秀芸*，王禄山．生物质多糖的高效降解与降解酶(系)的精确定制.生物化学与生物物理进展2021，48(3):296-308.
9.吴秀芸，刘淑萍，赵越，陈冠军，王禄山*.快速展示糖苷水解酶活性架构单点突变导致结合力变化的电泳技术.生物化学与生物物理进展, 2018，45(5): 560~566.
10.吴秀芸,戴琳,张舒,尚伟昊,余俊红,黄小平,王禄山*.高效木聚糖降解酶系定制的新进展与挑战.微生物学通报, 2020, 47(7): 2278−2289.
