2014.09-2019.06，山东大学，微生物学，博士

2010.09-2014.06，西北师范大学，生命科学，本科

工作经历

2022.07至今，山东大学微生物技术研究院，副研究员

2019.06-2022.06，山东大学微生物技术研究院，博士后

研究方向

1.黏细菌不同家族分子伴侣的功能分化及其分子机制；

2.分子伴侣组对于合成生物学领域的前瞻性应用；

3.非模式黏细菌遗传操作技术的开发与利用。

科研项目

1.江苏省自然科学基金青年项目，2022.07-2025.06，20万，主持；

2.广东省基础与应用基础研究基金—区域联合基金青年项目，2022.10-2025.09，10万，主持；

3.国家博士后创新人才支持计划，2019.06-2022.06，20万，主持；

4.青岛市博士后应用研究项目，2019.09-2022.06，5万，主持。

发表论文

Li Zhuo, Tian-Yu Wan, Zhuo Pan, Jia-Ning Wang, Duo-Hong Sheng, Yue-Zhong Li*. A Dual-Functional Orphan Response Regulator Negatively Controls the Differential Transcription of Duplicate groELs and Plays a Global Regulatory Role in Myxococcus. mSystems. 2022, 7(2): e0105621.

Yuelan Li#,Li Zhuo#, Xiaobin Li, Yongqiang Zhu, Shuge Wu, Wei Hu, Tao Shen, Yue-Zhong Li*, changsheng Wu*. Myxadazoles, myxobacterium-derived isoxazole-benzimidazole hybrids with cardiovascular activities. Angewandte Chemie International Edition. 2021, 60, 21679-21684.

Li Zhuo, Zheng Zhang, Zhuo Pan, Duo-hong Sheng, Wei Hu, Yue-zhong Li*. CIRCE element evolved for the coordinated transcriptional regulation of bacterial duplicate groELs. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2018, 1861(10): 928-937.

Li Zhuo#, Yan Wang#, Zheng Zhang, Jian Li, Xiao-Hua Zhang, Yue-zhong Li*. Myxococcus xanthus DK1622 coordinates expressions of the duplicate groEL and single groES genes for synergistic functions of GroELs and GroES. Frontiers in Microbiology. 2017, 8: 733.

Li Zhuo, Yan Wang, Zheng Zhang, Yue-zhong Li*. Dynamic Interplay of the Myxobacterial Chaperonins. Book: Prokaryotic Chaperonins: Multiple Copies and Multitude Functions. 2017. Springer, Chapter 4: 53-65.

Xin-jing Yue*, Duo-hong Sheng,Li Zhuo, Yue-zhong Li*. Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism. Engineering Microbiology. 2023, 3, 100075.

Jia-Qi Hu#, Jing-Jing Wang#, Yue-Lan Li,Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen, Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Combine NMR-based metabolic profiling and genome mining for the accelerated discovery of archangiumide, an allenic macrolide from the myxobacterium Archangium violaceum SDU8. Organic Letters. 2021, 23, 2114-2119.

Zhuo Pan, Zheng Zhang,Li Zhuo, Tian-yu Wan, Yue-zhong Li*. Bioinformatic and functional characterization of Hsp70s in Myxococcus xanthus. mSphere. 2021, 6: e00305-21.

Duo-hong Sheng#, Xiao-jing Chen#, Ya-jie Li, Jing-jing Wang,Li Zhuo, Yue-zhong Li*. ParC, a new partitioning protein, is necessary for the active form of ParA from Myxococcus pMF1 plasmid. Frontiers in Microbiology. 2021, 11: 623-699.

Xiao-jing Chen,Zheng Zhang,Ya-Jie Li,Li Zhuo,Duo-Hong Sheng,Yue-Zhong Li*. Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02. FEMS Microbiology Ecology. 2020(3): 3.

Xiao-jing Chen, Kui Han, Jing Feng,Li Zhuo, Ya-jie Li, Yue-zhong Li. The complete genome sequence and analysis of a plasmid-bearing myxobacterial strain Myxococcus fulvus 124B02 (M 206081). Standards in Genomic Sciences. 2016, 11(1).