教育背景
2014.09-2019.06，山东大学，微生物学，博士
2010.09-2014.06，西北师范大学，生命科学，本科
工作经历
2022.07至今，山东大学微生物技术研究院，副研究员
2019.06-2022.06，山东大学微生物技术研究院，博士后
研究方向
科研工作围绕“黏细菌分子伴侣组的化学生态学”展开，旨在解决“如何更好地实现黏细菌资源的开发与利用”这一关键问题，主要包括以下几个方面：
1.黏细菌多拷贝分子伴侣组的功能分化、分子进化及其调控机制，为分子伴侣的进一步改造利用奠定基础；
2.分子伴侣对于次级代谢产物的影响及其在合成生物学领域的前瞻性应用，为沉默基因簇激活方法的建立提供启发；
3.改造利用分子伴侣组以实现黏细菌对病原菌的智慧捕食，有助于建立农业优异性状形成和演化规律的新范式；
4.非模式黏细菌遗传操作及菌群遗传改造技术的挖掘与探索，为其他非模式微生物的遗传改造提供借鉴和指导，有助于推进微生物稀缺资源的深度开发与利用。
1.国家重点研发计划，子课题负责人，2023.12-2028.11，在研；
2.国家自然科学基金青年项目，主持，2025.01-2027.12，在研；
3.山东省自然科学基金青年项目，主持，2024.01-2026.12，在研；
4.江苏省自然科学基金青年项目，主持，2022.07-2025.06，在研；
5.广东省基础与应用基础研究基金—区域联合基金青年项目，主持，2022.10-2025.09，在研；
6.国家博士后创新人才支持计划，主持，2019.06-2022.06，结题；
7.青岛市博士后应用研究项目，主持，2019.09-2022.06，结题。
发表论文
Tian-yu Wan,Li Zhuo*, Zhuo Pan, Rui-yun Chen, Han Ma, Ying Cao, Jianing Wang, Jing-jing Wang, Wei-feng Hu, Ya-jun Lai, Muhammad Hayat, Yue-zhong Li*. Dosage constraint of the ribosome-associated molecular chaperone drives the evolution and fates of its duplicates in bacteria.mBio. 2024. accepted.
Tian-yu Wan, Ying Cao, Ya-jun Lai, Zhuo Pan, Yue-zhong Li*,Li Zhuo*. Functional investigation of the two ClpPs and three ClpXs in Myxococcus xanthus DK1622.mSphere. 2024. e00363-24.
Muhammad Hayat, Tian Gao, Ying Cao, Muhammad Rafiq*,Li Zhuo*, Yue-zhong Li. Identification of prospective Ebola virus VP35 and VP40 protein inhibitors from myxobacterial natural products.Biomolecules. 2024. 14, 660.
Li Zhuo, Tian-Yu Wan, Zhuo Pan, Jia-Ning Wang, Duo-Hong Sheng, Yue-Zhong Li*. A Dual-Functional Orphan Response Regulator Negatively Controls the Differential Transcription of Duplicate groELs and Plays a Global Regulatory Role in Myxococcus.mSystems. 2022, 7(2): e0105621.
Yuelan Li#,Li Zhuo#, Xiaobin Li, Yongqiang Zhu, Shuge Wu, Wei Hu, Tao Shen, Yue-Zhong Li*, changsheng Wu*. Myxadazoles, myxobacterium-derived isoxazole-benzimidazole hybrids with cardiovascular activities.Angewandte Chemie International Edition. 2021, 60, 21679-21684.
Li Zhuo, Zheng Zhang, Zhuo Pan, Duo-hong Sheng, Wei Hu, Yue-zhong Li*. CIRCE element evolved for the coordinated transcriptional regulation of bacterial duplicate groELs.Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2018, 1861(10): 928-937.
Li Zhuo#, Yan Wang#, Zheng Zhang, Jian Li, Xiao-Hua Zhang, Yue-zhong Li*. Myxococcus xanthus DK1622 coordinates expressions of the duplicate groEL and single groES genes for synergistic functions of GroELs and GroES.Frontiers in Microbiology. 2017, 8: 733.
Li Zhuo, Yan Wang, Zheng Zhang, Yue-zhong Li*. Dynamic Interplay of the Myxobacterial Chaperonins. Book: Prokaryotic Chaperonins: Multiple Copies and Multitude Functions. 2017. Springer, Chapter 4: 53-65.
Pan, Z.,Zhuo, L., Wan, T. Y., Chen, R. Y., Li, Y. Z.*. DnaK duplication and specialization in bacteria correlates with increased proteome complexity.mSystems. 2024. 9(4): e0115423.
Xin-jing Yue*, Duo-hong Sheng,Li Zhuo, Yue-zhong Li*. Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism.Engineering Microbiology. 2023, 3, 100075.
Jia-Qi Hu#, Jing-Jing Wang#, Yue-Lan Li,Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen, Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Combine NMR-based metabolic profiling and genome mining for the accelerated discovery of archangiumide, an allenic macrolide from the myxobacterium Archangium violaceum SDU8.Organic Letters. 2021, 23, 2114-2119.
Zhuo Pan, Zheng Zhang,Li Zhuo, Tian-yu Wan, Yue-zhong Li*. Bioinformatic and functional characterization of Hsp70s in Myxococcus xanthus.mSphere. 2021, 6: e00305-21.
Duo-hong Sheng#, Xiao-jing Chen#, Ya-jie Li, Jing-jing Wang,Li Zhuo, Yue-zhong Li*. ParC, a new partitioning protein, is necessary for the active form of ParA from Myxococcus pMF1 plasmid.Frontiers in Microbiology. 2021, 11: 623-699.
Xiao-jing Chen, Zheng Zhang, Ya-Jie Li,Li Zhuo, Duo-Hong Sheng, Yue-Zhong Li*. Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02.FEMS Microbiology Ecology. 2020(3): 3.
Xiao-jing Chen, Kui Han, Jing Feng,Li Zhuo, Ya-jie Li, Yue-zhong Li. The complete genome sequence and analysis of a plasmid-bearing myxobacterial strain Myxococcus fulvus 124B02 (M 206081).Standards in Genomic Sciences. 2016, 11(1).
