教授 & 研究员

王霞

教授
博士/硕士生导师
13075343592
个人简介 科研项目 学术论文 其他介绍

教育背景

博士:2004/09-2008/07,山东大学,发酵工程

硕士:1998/09-2001/01,无锡轻工业大学,发酵工程

学士:1994/09-1998/07,山东轻工业学院,发酵工程


工作经历

2025/01-至今,山东大学,微生物改造技术全国重点实验室,教授

2014/09-2025/01,山东大学,微生物技术国家重点实验室,教授

2013/02-2014/02,美国华盛顿州立大学,分子生物科学学院,访问学者

2008/09-2014/08,山东大学,微生物技术国家重点实验室,副教授

2003/09-2008/09,山东大学,微生物技术国家重点实验室,讲师

2001/07-2003/09,山东大学,微生物技术国家重点实验室,助教


主要研究方向为环境微生物学、合成生物学及生物传感技术。近年在Trends in BiotechnologyBiosensors and BioelectronicsChemSusChem等国际期刊发表SCI论文50余篇,中科院1区占比近50%。

1.电活性微生物及其应用:挖掘新型电活性微生物,探究电活性微生物的胞外电子传递机制;并利用电活性微生物构建生物电化学系统进行CO2转化高附加值产品、环境污染物的降解与能源回收等研究。

2.微生物多聚物的生物合成:通过基因工程改造等技术构建微生物多聚物如结冷胶、黄原胶的高产菌株,并进行微生物多聚物的发酵生产与分离提取。

3.生物传感技术:利用基因工程改造、人工定向进化等技术挖掘具有高特异性和高亲和力的合成生物感知元件,开发应用于医学诊断、环境污染物监测及食品安全检测的生物传感技术。

科研项目

1.2024.06-2026.12,三电极传感器丝网印刷检测技术开发,横向课题。

2.2021.01-2024.12,一株鞘氨醇杆菌的胞外电子传递机制研究,国家自然科学基金面上项目。

3.2020.01-2023.12,近海沉积物中硫氧化主要菌群与关键通路的研究(子课题:硫化物检测传感器构建),国家自然科学基金重大研发计划。

4. 2021.01-2024.12,生物反应器监控系统重构与工业生物过程优化(子课题),国家重点研发计划“合成生物学”专项。

5. 2019.01-2020.12,基于还原氧化石墨烯/纳米多孔金修饰的微生物传感器对硫化物的灵敏性检测研究,山东省科技发展计划项目。

6.2017.01-2019.12,微网过滤生物反应器工艺特性及作用机制研究,山东大学交叉学科培育项目。

7. 2016.01-2019.12,基于硫醌氧化还原酶表达的微生物传感器构建及其对环境污染物硫化物检测研究,国家自然科学基金面上项目。

8.2014.01-2016.12,基于纳米多孔金辣根过氧化物酶传感器构建及其对废水中芳香族污染物检测技术开发,山东省科技发展计划项目。

9. 2012.01-2015.12,微生物与纳米材料组装复合体降解有机污染物的研究,国家自然科学基金面上项目。

10. 2010.10-2013.10,纳米颗粒与微生物复合体降解六价铬的研究,山东省优秀中青年科学家科研奖励基金。

11. 2006.12-2010.12,谷氨酸棒杆菌的代谢工程与蛋白组学研究,国家高技术研究发展计划(863计划)子课题。

12. 2008.01-2008.12,发酵法生产结冷胶多糖结构动力学研究,国家自然科学基金青年科学基金项目。

1.Xiaoyan Qi, Xinyu Gao,Xia Wang*, Ping Xu*.HarnessingPseudomonas putidain bioelectrochemical systems.Trends in Biotechnology, 2024, 42: 877-894.

2.Ting Cai, Xinyu Gao, Xiaoyan Qi, Xiaolei Wang, Ruijun Liu, Lei Zhang,Xia Wang*. Role of the cathode chamber in microbial electrosynthesis: A comprehensive review of key factors.Engineering Microbiology, 2024, 4: 100141.

3.Xiaoyan Qi, Huangwei Cai, Xiaolei Wang, Liu Ruijun, Cai Ting, Wang Sen, Liu Xueying,Xia Wang*. Electricity generation byPseudomonas putidaB6-2 in microbial fuel cells using carboxylates and carbohydrate as substrates.Engineering Microbiology, 2024, 4: 100148.

4. Ting Cai, Keshuhai Shang, Xiaolei Wang, Xiaoyan Qi, Ruijun Liu,Xia Wang*.Integration of glutamate dehydrogenase and nanoporous gold for electrochemical detection of glutamate.Biosensors-Basel, 2023, 13, 1023.

5.Gao Xinyu, Chen Siyu, Wang Xiaolei, Liu Honglei,Xia Wang*.A portable nanoporous gold modifiedscreen-printed sensor for reliable and simultaneousmulti-vitamins analysis.Chemosensors, 2023, 11, 502.

6.Xiao Sa, Zhang Lei, Xiaolei Wang, Li Wenjuan,Xia Wang*.The signal conversion strategy using the lytic transglycosylaseCag4-double nanoporous gold co-catalysis for the rapid screening of drugs against Helicobacter pylori infection.Biosensors and Bioelectronics, 2023, 233: 115345.

7.Qi Xiaoyan, Zhang Lei, Wang Xiaolei, Chen Siyu,Xia Wang*. A label-free colorimetric aptasensor based on an engineered chimeric aptamer and Au@FeP nanocomposites for the detection of kanamycin.Food Control, 2023, 149: 109700.

8. Xiaoyan Qi, Huimin Wang, Xinyu Gao, Lei Zhang, Sen Wang,Xia Wang*, Ping Xu*.Efficient power recovery from aromatic compounds by a novel electroactive bacteriumPseudomonas putidaB6-2 in microbial fuel cells.Journal of Environmental Chemical Engineering, 2022, 10: 108536.

9.Sa Xiao, Keshuai Shang, Lei Zhang, Wenjuan Li,Xia Wang*.A rapid anti-Helicobacter pyloribiofilm drug screening biosensor based on AlpB outer membrane protein and colloidal gold/nanoporous gold framework.Biosensors and Bioelectronics, 2022, 215:114376.

10. Huimin Wang, Xiaoyan Qi, Lei Zhang, Xueli Zhang, Ping Xu,Xia Wang*.Efficient bioelectricity generation and carbazole biodegradation usingan electrochemically active bacteriumSphingobium yanoikuyaeXLDN2-5.Chemosphere, 2022, 307: 135986.

11. Keshuai Shang, Shuangjue Wang, Siyu Chen,Xia Wang*. Sensitivity detection of uric acid and creatinine in human urine based on nanoporous gold.Biosensors-Basel, 2022, 12: 588.

12.Siyu Chen, Keshuai Shang, Xinyu Gao,Xia Wang*.The development ofNAD+-dependent dehydrogenase screen-printed biosensor based on enzyme and nanoporous gold co-catalytic strategy.Biosensors and Bioelectronics, 2022,211:11437.

13.Huimin Wang, Xiaoyan Qi, Siyu Chen,Xia Wang*. The efficient treatment of breeding wastewater by an electroactive microbial community in microbial fuel cell.Journal of Environmental Chemical Engineering, 2022, 10: 107187.

14. Sa Xiao,Keshuai Shang, Wenjuan Li,Xia Wang*. An efficient biosensor based on the synergistic catalysis ofHelicobacter pyloriurease b subunit and nanoplatinum for urease inhibitors screening and antagonistic mechanism analyzing.Sensors and Actuators B: Chemical, 2022, 355:131284.

15. Yachao Zhang, Huimin Wang, Keshuai Shang,Xia Wang*, Ping Xu*.Reliable detection ofListeria monocytogenesby a portable paper-based multi-biocatalyst platform integrating three biomarkers: gene hly, acetoin, andlisteriolysin O protein.Journal of Electroanalytical Chemistry, 2022, 905:115975.

16. Shuangjue Wang, Siyu Chen, Keshuai Shang, Xinyu Gao,Xia Wang*. Sensitive electrochemical detection of cholesterol using a portable paper sensor based on the synergistic effect of cholesterol oxidase and nanoporous gold.International Journal of Biological Macromolecules, 2021, 189: 356-362.

17.Sa Xiao, Shuangjue Wang,Xia Wang*, Ping Xu*. Nanoporous gold: a review and potentials in biotechnological and biomedical applications.Nano Select,2021, 2: 1437-1458.

18.Xueli Zhang, Huimin Wang, Tian Xia,Xia Wang*.Characterization of a new electrochemically active bacterium phylogenetically related toAlicyclobacillus hesperidumand its electrochemical performance in microbial fuel cell.Biosensors and Bioelectronics,2021, 175: 112865.

19. Congcong Bian, Huimin Wang, Xueli Zhang, Sa Xiao, Zhuang Liu,Xia Wang*. Sensitive detection of low-concentration sulfide based on the synergistic effect of rGO, np-Au, and recombinant microbial cell.Biosensors and Bioelectronics, 2020, 151: 111985.

20. Tian Xia, Xueli Zhang, Huimin Wang, Yachao Zhang, Yan Gao, Congcong Bian,Xia Wang*, Ping Xu. Power generation and microbial community analysis in microbial fuel cells: A promising system to treat organic acid fermentation wastewater.BioresourcceTechnology, 2019, 284: 72-79.

21. Yachao Zhang, Yan Gao, Xueli Zhang, Huiming Wang, Tian Xia, Congcong Bian, Shuang Liang, Xiaozhi Tang,Xia Wang*.Electrochemical immunosensor for HBe antigen detection based on a signal amplification strategy: The co-catalysis of horseradish peroxidase and nanoporous gold.Sensors and Actuators B: Chemical, 2019, 284: 296-304.

22. Zhuang Liu, Yachao Zhang, Congcong Bian, Tian Xia, Yan Gao, Xueli Zhang, Huimin Wang, Hanyue Ma, Yuan Hu,Xia Wang*.Highly sensitive microbial biosensor based on recombinantEscherichia colioverexpressing catechol 2,3-dioxygenase for reliable detection of catechol.Biosensors and Bioelectronics, 2019, 126:51-58.

23. Hanyue Ma, Tian Xia, Congcong Bian, Huihui Sun, Zhuang Liu, Chao Wu,Xia Wang*, Ping Xu.Bacterial electroactivity and viability depends on the carbon nanotube-coated sponge anode used in a microbial fuel cell.Bioelectrochemistry, 2018, 122: 26-31.

24. Zhuang Liu, Hanyue Ma, Huihui Sun, Rui Gao, Honglei Liu,Xia Wang*, Ping Xu, Luying Xun. Nanoporous gold-based microbial biosensor for direct determination of sulfide.Biosensors and Bioelectronics, 2017, 98:29-35.

25. Huihui Sun, Hanyue Ma, Zhuang Liu, Yufei Li, Ping Xu,Xia Wang*. Effect of Fe3O4nanoparticles onSphingobium yanoikuyaeXLDN2-5 cells in carbazole biodegradation.NanotechnologyEnvironmental Engineering,2017, 2: 5.

26. Huihui Sun, Zhuang Liu, Chao Wu, Ping Xu,Xia Wang*. Amperometric inhibitive biosensor based on horseradish peroxidase-nanoporous gold for sulfide determination.ScientificReports, 2016, 6:30905.

27.Chao Wu, Zhuang Liu, Huihui Sun,Xia Wang*, Xu Ping. Selective determination of phenols and aromatic amines based onhorseradish peroxidase-nanoporous gold co-catalytic strategy.Biosensors and Bioelectronics, 2016, 79:843-849.

28. Chao Wu, Huihui Sun, Yufei Li, Xueying Liu, Xiaoyu Du,Xia Wang*, Xu Ping.Biosensor based on glucose oxidase-nanoporous gold co-catalysis for glucose detection.Biosensors and Bioelectronics, 2015, 66(4), 350-355.

29. Chao Wu, Xueying Liu, Yufei Li, Xiaoyu Du,Xia Wang*, Xu Ping. Lipase-nanoporous gold biocomposite modified electrode for reliable detection of triglycerides.Biosensors and Bioelectronics, 2014, 53:26-30.

30.Xueying Liu, Xiaoyu Du,Xia Wang*, Naiqiang Li, Ping Xu, Yi Ding. Improved microbial fuel cell performance by encapsulating microbial cells with a nickel-coated sponge.Biosensors and Bioelectronics,2013, 41:848-851.

31.Xiaoyu Du, Xueying Liu,Yufei Li,Chao Wu,Xia Wang*, Ping Xu. Efficient biocatalyst by encapsulating lipase into nanoporous gold.Nanoscale Research Letters, 2013, 8:180-185.

32. Yufei Li, Xiaoyu Du, Chao Wu, Xueying Liu,Xia Wang*, Ping Xu. An efficient magnetically modified microbial cell biocomposite for carbazole biodegradation.Nanoscale Research Letters, 2013, 8:522-526.

33.Xia Wang, Xueying Liu, Xiuling Yan, Peng Zhao, Yi Ding*, Ping Xu*. Enzyme-Nanoporous gold biocomposite: excellent biocatalyst with improved biocatalytic performance and stability.PLoSOne, 2011, 6:e24207.

34.Xia Wang, Xueying Liu, Chuanming Zhao, YiDing*, Ping Xu*.Biodieselproduction in packed-bed reactors using lipase-nanoparticle biocomposite.BioresourcceTechnology, 2011, 102:6352-6355.

35.Xia Wang, Peipei Dou, Peng Zhao, Chuanming Zhao, Yi Ding*, Ping Xu*.Immobilization of lipases onto magnetic Fe3O4nanoparticles for application in biodiesel production.ChemSusChem, 2009, 2:947-950.

36.Xia Wang,Chuanming Zhao, Peng Zhao, Peipei Dou, Yi Ding, Ping Xu*.Gellan gel beads containing magnetic nanoparticles: An effective biosorbent for the removal of heavy metals from aqueous system.BioresourcceTechnology, 2009, 100:2301-2304.

37.Xia Wang,Zhonghui Gai, Bo Yu,Jinhui Feng, Changyong Xu, Yong Yuan, Zhixin Lin, Ping Xu*.Degradation of carbazole by microbial cells immobilized in magnetic gellan gum gel beads.Applied Environmental Microbiology, 2007, 73:6421-6428.

38.Xia Wang, Yong Yuan, Kainan Wang, Dezhong Zhang, Zhengting Yang, Ping Xu*. Deproteinization of gellan gum produced bySphingomonas paucimobilisATCC 31461.Journal of Biotechnology, 2007, 128:403-407.

39.Xia Wang,Ping Xu*, Yong Yuan, Changlong Liu, Dezhong Zhang, Zhengting Yang, Chunyu Yang, Cuiqing Ma.Modeling for gellan gum production bySphingomonas paucimobilisATCC 31461 in a simplified medium.Applied Environmental Microbiology, 2006, 72:3367-3374.

获奖情况

1.王霞,2017年山东省优秀硕士学位论文指导奖

2.王霞,2017年山东大学优秀硕士学位论文指导奖

3.王霞,2009年山东省优秀博士学位论文

4.王霞,2010年全国百篇优秀博士学位论文提名奖论文


所获专利

1.一种利用酶修饰电极检测尿液中同型半胱氨酸的方法,中国发明专利,专利号:ZL202110527576.3

2.一种筛选幽门螺杆菌脲酶抑制剂的方法,中国发明专利,专利号:ZL202110741469.0

3.一种基于溶血素O的单增李斯特菌检测试纸条及其制备与应用,中国发明专利,专利号:ZL202010037065.9

4.一种基于检测核酸hly与乙偶姻的双功能传感器检测单增李斯特菌的方法,中国发明专利,专利号:ZL202010294110.9

5.一种利用还原氧化石墨烯纳米材料改良生物电极构建的方法,中国发明专利,专利号:ZL202010037065.9

6.一种利用纳米多孔金辣根过氧化物酶传感器快速检测废水中芳香族污染物的方法,中国发明专利,专利号:ZL201510888274.3

7.一株高产结冷胶的少动鞘氨醇单孢菌及其应用,中国发明专利,专利号:ZL200610068788.5

8.一种结冷胶发酵液的脱蛋白方法,中国发明专利,专利号:ZL200610068787.0