科研项目
1.2021.01-2025.12，山东大学杰出中青年学者学科建设经费
2.2023.01-2025.12，电氢能组合固碳与催化转化，国家重点研发计划子课题
3.2023.01-2026.12，恶臭假单胞菌KT2440感应并动态调控L-2-羟基戊二酸代谢的分子机制研究，国家自然科学基金面上项目
4.2025.01-2029.12，新污染物识别与响应合成生物体系的构建及应用，国家重点研发计划课题
5.2025.01-2027.12，生物基1,5-戊二酸技术开发项目，横向项目
6.2020.01-2024.12，微生物进化改造技术开发及抗逆元件挖掘，国家重点研发计划子课题
代表性论文
1.Kang Zhaoqi; Zhang Manman; Gao Kaiyu; Zhang Wen; Meng Wensi; Liu Yidong; Xiao Dan; Guo Shiting; Ma Cuiqing;Gao Chao*; Xu Ping; An L-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR,Nature Communications,2021, 12: 3619
2.Xiao Dan; Zhang Wen; Guo Xiaoting; Liu Yidong; Hu Chunxia; Guo Shiting; Kang Zhaoqi; Xu Xianzhi; Ma Cuiqing;Gao Chao* Xu Ping; A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR,Nature Communications,2021, 12: 7108
3.Meng, Wensi; Zhang, Lijie; Cao, Menghao; Zhang, Yongjia; Zhang, Yipeng; Li, Ping; Kang, Zhaoqi; Guo, Shiting; Xu, Ping; Ma, Cuiqing;Gao Chao*; 2,3-Butanediol synthesis from glucose supplies NADH for elimination of toxic acetate produced during overflow metabolism,Cell Discovery,2021, 7: 43
4.Cao Menghao; Sun Weikang; Wang Shuo; Di Haiyan; Du Qihang; Tan Xiaoxu; Meng Wensi; Kang Zhaoqi; Liu Yidong; Xu Ping; Lü Chuanjuan; Ma Cuiqing;Gao Chao*; Efficient L-valine production using systematically metabolic engineered Klebsiella oxytoca,Bioresource Technology,2024, 395: 130403
5.Kang Zhaoqi; Hou Shuang; Gao Kaiyu; Liu Yidong; Zhang Ning; Fang Zhiqing; Zhang Wen; Xu Xianzhi; Xu Rong; Lü Chuanjuan; Ma Cuiqing; Xu Ping;Gao Chao; An ultrasensitive biosensor for probing subcellular distribution and mitochondrial transport of L‐2‐hydroxyglutarate,Advanced Science, 2024, 11: e2404119
6.Zhang Yipeng; Ma Liting; Sun Weikang; Xiao Dan; Lü Chuanjuan; Wang Qian; Xu Ping; Ma Cuiqing;Gao Chao*; An in vitro cascade with four enzymes for the production of D-3,4- dihydroxybutyric acid from D-xylose, Green Chemistry,2022, 24: 7602-7611
7.Meng Wensi; Ma Cuiqing; Xu Ping;Gao Chao; Biotechnological production of chiral acetoin,Trends in Biotechnology, 2022, 40: 958-973
8.Liu Yidong; Sun Wenxuan; Ma Liting; Xu Rong; Yang Chunyu; Xu Ping; Ma Cuiqing;Gao Chao*; Metabolic mechanism and physiological role of glycerol 3-phosphate in Pseudomonas aeruginosa PAO1,mBio, 2022, 13: e0262422
9.Xiao Dan; Xu Xianzhi; Gao Kaiyu; Wang Mengjiao; Zhang Wen; Lü Chuanjuan; Wang Xia; Wang Qian; Xu Ping; Ma Cuiqing;Gao Chao*; A Förster resonance energy transfer-based D-2- hydroxyglutarate biosensor,Sensors and Actuators: B. Chemical, 2023, 385: 133681
10.Tan Xiaoxu; Guo Shiting; Wang Yuxian; Zhang Yipeng; Zhang Hongxu; Lü Chuanjuan; Wang Qian; Xu Ping; Ma Cuiqing;Gao Chao*; Multi-enzyme cascade excluding costly cofactors for pyruvate production from glucose,Chemical Engineering Journal, 2023, 463: 142473
11.Zhang Wen; Yang Mu; Wang Gang; Ou Shaowu; Hu Jinqu; Liu Jiyuan; Lei Yuxin; Kang Zhaoqi; Wang Fang; Liu Jiang; Ma Cuiqing; Wang Chengwei;Gao Chao*; Tang Dongqi; A biosensor for D-2- hydroxyglutarate in frozen sections and intraoperative assessment of IDH mutation status,Biosensors and Bioelectronics, 2024, 247: 115921
12.Hou Shuang; Kang Zhaoqi; Liu Yidong; Lü Chuanjuan; Wang Xia; Wang Qian; Ma Cuiqing; Xu Ping;Gao Chao*; An enzymic L-2-hydroxyglutarate biosensor based on L-2-hydroxyglutarate dehydrogenase from Azoarcus olearius,Biosensors and Bioelectronics, 2024, 243: 115740
13.Liu Yidong; Kang Zhaoqi; Zhang Wen; Ma Cuiqing; Xu Ping;Gao Chao*; Metabolic functions of misunderstood D-2-hydroxyglutarate,The Innovation Life, 2024, 2(4): 100101
14.Zhang Manman,Gao Chao*, Guo Xiaoting, Guo Shiting, Kang Zhaoqi, Xiao Dan, Yan Jinxin, Zhang Wen, Tao Fei, Dong Wenyue, Liu Pan, Yang Chen, Ma Cuiqing, Xu Ping*, Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.Nature Communications,2018, 9:2114.
15.Zhang Wen, Zhang Manman,Gao Chao*, Zhang Yipeng, Ge Yongsheng, Guo Shiting, Guo Xiaoting, Zhou Zikang, Liu Qiuyuan, Zhang Yingxin, Ma Cuiqing, Tao Fei, Xu Ping*, Coupling between D-3-phosphoglycerate dehydrogenase and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis.Proc Natl Acad Sci U S A. 2017, 114, E7574-E7582.
获奖情况
2021年山东大学杰出中青年学者
2020年教育部青年长江学者
2019年山东大学齐鲁青年学者
2018年山东省杰出青年科学基金
2015年山东大学青年学者未来计划
2015年度山东省暨山东大学优秀硕士学位论文指导教师
2020年度山东省暨山东大学优秀硕士学位论文指导教师
2023年度山东省暨山东大学优秀博士学位论文指导教师
2023年度教育部自然科学二等奖
所获专利
一株重组大肠杆菌及其在生产2-丁醇中的应用，ZL201510713808.9
一种加速5-氨基戊酸生物法生产的方法，ZL201610628388.9
一种D-乳酸氧化酶及其在D-乳酸检测中的应用，ZL201510135775.4
一株基因工程菌及其在生产(2R,3R)-2,3-丁二醇中的应用，ZL201410314730.9
一种利用L-赖氨酸2-单加氧酶和δ-戊酰胺水解酶催化制备5-氨基戊酸方法，ZL201310241389.4
