山东大学微生物技术研究院教授，博士/硕士生导师，山东省优秀青年基金获得者、山东大学齐鲁青年学者第一层次人才。主要从事海洋自养微生物光能利用机制与进化研究，研究成果发表于NaturePlants、PNAS、Nature Communications、Science Advances、Plant Cell、eLife、Plant Physiology等国际著名学术期刊。学术成果作为重要组成部分获得“山东省自然科学一等奖”（5/9），入选2020、2022、2023和2024年“中国海洋与湖沼十大科技进展”。申请人获得山东省优秀青年基金、齐鲁青年学者等人才项目资助。主持国家重点研发计划课题、国家自然科学基金、中国博士后自然科学基金面上项目及“站中特别资助”项目、山东省自然科学基金青年项目等；中国微生物学会永久会员，中国微生物学会自养微生物专业委员会委员，山东植物学会理事，山东省微生物学会青年专业委员会委员。
教育背景：
(1) 2012-09至2017-06,山东大学,微生物学,博士
(2) 2008-09至2012-06,山东大学,生物技术,学士
工作经历：
(1) 2025-01至今,山东大学,微生物改造技术全国重点实验室,教授，齐鲁青年学者
(2) 2023-06至2024-12,山东大学,微生物改造技术全国重点实验室,研究员，齐鲁青年学者
(3) 2020-06至2023-05,山东大学，微生物技术国家重点实验室，特别资助博士后
(4) 2018-06至2020-05,山东大学，微生物技术国家重点实验室，博士后
(5) 2018-02至2020-02, Institute of Integrative Biology, University of Liverpool, Research Associate
研究方向：
海洋自养微生物光合作用机理、光能利用机制与进化研究。利用结构生物学、生物化学、生理学和分子生物学的技术方法研究海洋微藻光系统的结构和功能以及光合膜的结构和环境适应。
一、海洋微藻典型类群的光系统超复合物的结构、光能转化机制及进化方式。
二、海洋微藻天然光合膜的超分子结构、环境适应机制及对光合效率的调控机制。
主要项目：
(1)中华人民共和国科学技术部,国家重点研发计划课题, 2023YFA0914602,高效固碳元件的挖掘与解析, 2024-01至2028-12, 416万元,在研,主持
(2)山东省自然科学基金委员会,优秀青年科学基金, ZR2024YQ027,藻类光合作用机制与进化, 2025-01至2027-12, 50万元,在研,主持
(3)国家自然科学基金委员会,面上项目,32570122,海洋单细胞颗石藻光系统-捕光天线复合体的结构与功能及其光适应与进化, 2026-01-01至2029-12-31,50万元,在研,主持
(4)国家自然科学基金委员会,青年科学基金项目, 32100200,快速生长生态型蓝藻Synechococcus elongatus 2973光合膜高效转化光能的超分子结构基础, 2022-01-01至2024-12-31, 30万元,在研,主持
(5)山东省自然科学基金委员会,青年基金, ZR2020QC024,蓝藻光合膜上光合复合物的排布模式及IsiA蛋白对其排布模式的调控机制研究, 2021-01至2023-12, 14万元,结题,主持
(6)中国博士后科学基金会,站中特别资助, 2021T140412,快速生长生态型蓝藻Synechococcus elongatus 2973光合膜高效转化光能的超分子结构基础, 2021-07至2023-05, 18万元,结题,主持
(7)中国博士后科学基金会,面上项目, 2020M682166,高光合效率蓝藻的光合膜超分子结构及其对光合效率的调控机制研究, 2021-01至2023-05, 8万元,结题,主持
(8)中国博士后科学基金会,面上项目, 2019M662335,蓝藻光合膜上IsiA蛋白与光合装置的组装及排布研究, 2019-12至2020-05, 8万元,结题,主持
代表性论文：
1.Long-sheng Zhao, Tuomas Huokko, Sam Wilson, Deborah M. Simpson, Qiang Wang, Alexander V. Ruban, Conrad W. Mullineaux, Yu-Zhong Zhang* and Lu-Ning Liu*.Structural variability, coordination and adaptation of a native photosynthetic machinery,Nature Plants, 2020, 6(7): 869-882.
2.Fei-Yu He#,Long-Sheng Zhao#*, Xin-Xiao Qu#, Kang Li, Jian-Ping Guo, Fang Zhao, Ning Wang, Bing-Yue Qin, Xiu-Lan Chen, Jun Gao*, Lu-Ning Liu*, Yu-Zhong Zhang*. Structural insights into the assembly and energy transfer of haptophyte photosystem I–light-harvesting supercomplex, PNAS, 2024, 121(50):e2413678121.
3.Zhang, Y. Z., Li, K., Qin, B. Y., Guo, J. P., Zhang, Q. B., Zhao, D. L., ... &Zhao, L. S.(2024). 15(1), 4999. Structure of cryptophyte photosystem II–light-harvesting antennae supercomplex. Nature Communications,
4.Long-Sheng Zhao#, Ning Wang#, Kang Li#, Chun-Yang Li#, Jian-Ping Guo, Fei-Yu He, Gui-Ming Liu, Xiu-Lan Chen, Jun Gao*, Lu-Ning Liu*, Yu-Zhong Zhang*. Architecture of symbiotic dinoflagellate photosystem I–light-harvesting supercomplex in Symbiodinium,Nature Communications, 2024, 15: 2392.
5.Long-Sheng Zhao*, Chun-Yang Li, Xiu-Lan Chen, Qiang Wang, Yu-Zhong Zhang and Lu-Ning Liu*.Native architecture and acclimation of photosynthetic membranes in a fast-growing cyanobacterium,Plant physiology, 2022, 190(3), 1883-1895.
6.Long-Sheng Zhao#, Peng Wang#, Kang Li#, Quan-Bao Zhang, Fei-Yu He, Chun-Yang Li, Hai-Nan Su, Xiu-Lan Chen, Lu-Ning Liu*, Yu-Zhong Zhang*.Structural basis and evolution of the photosystem I–light-harvesting supercomplex of cryptophyte algae,Plant cell, 2023,35(7):2449-2463.
7.Long-Sheng Zhao, Hai-Nan Su*, Kang Li, Bin-Bin Xie, Lu-Ning Liu, Xi-Ying Zhang, Xiu-Lan Chen, Feng Huang, Bai-Cheng Zhou and Yu-Zhong Zhang.Supramolecular architecture of photosynthetic membrane in red algae in response to nitrogen starvation.Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2016, 1857(11), 1751-1758.
8.Long-Sheng Zhao, Yu-Zhong Zhang and Lu-Ning Liu*.Visualizing native supramolecular architectures of photosynthetic membranes in cyanobacteria and red algae using atomic force microscopy,Algal Biotechnology, edited by Dr Qiang Wang, published by CABI, 2023, 77-89.
9.Long-Sheng Zhao, Kang Li, Qian-Min Wang, Xiao-Yan Song*, Hai-Nan Su*, Bin-Bin Xie, Xi-Ying Zhang, Feng Huang, Xiu-Lan Chen, Bai-Cheng Zhou and Yu-Zhong Zhang.Nitrogen starvation impacts the photosynthetic performance ofPorphyridium cruentumas revealed by chlorophyll a fluorescence.Scientific Reports, 2017, 7(1): 8542.
10.Ping-Yi Li#, Yan-Qi Zhang#, Yi Zhang#, Wen-Xin Jiang, Yan-Jun Wang, Yi-Shuo Zhang, Zhong-Zhi Sun, Chun-Yang Li, Yu-Zhong Zhang, Mei Shi, Xiao-Yan Song,Long-Sheng Zhao*and Xiu-Lan Chen*.Study on a novel cold-active and halotolerant monoacylglycerol lipase widespread in marine bacteria reveals a new group of bacterial monoacylglycerol lipases containing unusual C(A/S)HSMG catalytic motifs.Frontiers in Microbiology, 2020, 11: 9.
11.Kang Li#,Long-Sheng Zhao#, He-Min Sun, Ruo-Cong Tang, Zhi-Hua Chen, Hai-Nan Su*, Xiu-Lan Chen and Yu-Zhong Zhang.Capsular polysaccharide production fromZunongwangia profundaSM-A87 monitored at single cell level by atomic force microscopy.Deep Sea Research Part II: Topical Studies in Oceanography, 2018, 155: 44-49.
12.Qian-Qian Cha, Xue-Bing Ren, Yuan-Yuan Sun, Xiao-Yan He, Hai-Nan Su, Xiu-Lan Chen, Yu-Zhong Zhang, Bin-Bin Xie,Long-Sheng Zhao*, Xiao-Yan Song* and Xi-Ying Zhang*.Shewanella polarissp. nov., a psychrotolerant bacterium isolated from Arctic brown algae.International Journal of Systematic and Evolutionary Microbiology, 2020, ijsem004022.
13.Qi Sheng#, Meng-Yao Zhang#, Si-Min Liu#, Zhuo-Wei Chen, Pei-Ling Yang, Hong-Su Zhang, Meng-Yun Liu, Kang Li,Long-Sheng Zhao, Ning-Hua Liu, Lu-Ning Liu, Xiu-Lan Chen, Jamie K Hobbs, Simon J Foster*, Yu-Zhong Zhang*, Hai-Nan Su*.In situ visualization of Braun’s lipoprotein onE. coli sacculi,Science Advances.
14.Nannan Xu#, Anne Oltmanns#,Long-sheng Zhao, Antoine Girot, Marzieh Karimi, Lara Hoepfner, Simon Kelterborn, Martin Scholz, Julia Beißel, Peter Hegemann, Oliver Baumchen, Lu-Ning Liu, Kaiyao Huang*, Michael Hippler*.Altered N-glycan composition impacts flagella-mediated adhesion inChlamydomonas reinhardtii, 2020,eLife,
15.Fang Zhao, Chun-Mei Yu, Hai-Ning Sun,Long-Sheng Zhao, Hai-Tao Ding, Hai-Yan Cao, Yin Chen, Qi-Long Qin, Yu-Zhong Zhang, Ping-Yi Li and Xiu-Lan Chen*.A novel class of xylanases specifically degrade marine red algal β1,3/1,4-mixed-linkage xylan,Journal of Biological Chemistry, 2023, 299(9):105116.
16.Hai-Nan Su, Kang Li,Long-Sheng Zhao, Xiao-Xue Yuan, Meng-Yao Zhang, Si-Min Liu, Xiu-Lan Chen, Lu-Ning Liu* and Yu-Zhong Zhang*.Structural Visualization of Septum Formation in Staphylococcus warneri Using Atomic Force Microscopy.Journal of bacteriology, 2020, 202(19): e00294-20.
17.Leanne Miller,Long-sheng Zhao, Daniel Canniffe, David Martin and Lu-Ning Liu*.Unfolding pathway and intermolecular interactions of the cytochrome subunit in the bacterial photosynthetic reaction center,Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2020.
18.Matthew Faulkner,Long-sheng Zhao, Steve Barrett and Lu-Ning Liu*.Self-assembly stability and variability of bacterial microcompartment shell proteins in response to the environmental change.Nanoscale Research Letters, 2019, 14(1):54.
19.Fang Zhao, Hai-Yan Cao,Long-Sheng Zhao, Yi Zhang, Chun-Yang Li, Yu-Zhong Zhang, Ping-Yi Li, Peng Wang and Xiu-Lan Chen*.A novel subfamily of endo-β-1, 4-glucanases in glycoside hydrolase family 10.Applied and Environmental Microbiology, 2019, 85(18): e01029-19.
20.Kang Li, Xiao-Xue Yuan, He-Min Sun,Long-Sheng Zhao, Ruo-cong Tang, Zhi-Hua Chen, Qi-Long Qin, Xiu-Lan Chen, Yu-Zhong Zhang and Hai-Nan Su*.Atomic force microscopy of side wall and septa peptidoglycan fromBacillus subtilisreveals an architectural remodeling during growth.Frontiers in Microbiology, 2018, 9: 620.
