科研项目
1.国家自然科学基金面上项目，42176229，2022.01-2025.12，主持
2.国家自然科学基金重大研究计划培育项目，91751101，2018.01-2020.12，主持
3.国家自然科学基金面上项目，41676180，2017.01-2020.12，主持
4.青岛海洋科学与技术国家实验室开放基金项目，QNLM2016ORP0310，2017.04-2020.03，主持
5.山东大学未来学者计划，2017WLJH57，2017.07-2022.06，主持
6.山东大学基本科研业务费，2016TB010，2016.07-2018.12，主持
7.中国博士后科学基金面上资助，2013M53158，2013.08-2015.08，主持
8.山东省博士后创新基金，201301009，2013.10-2015.10，主持
代表性论文
1. Jiang WX#,Li PY#*, Chen XL, Zhang YS, Wang JP, Wang YJ, Sheng Q, Sun ZZ, Qin QL, Ren XB, Wang P, Song XY, Chen Y, Zhang YZ*. A pathway for chitin oxidation in marine bacteria. Nat Commun, 2022, 13:5899
2. Qin QL#, Wang ZB#, Cha QQ, Liu SS, Ren XB, Fu HH, Sun ML, Zhao DL, McMinn A, Chen Y, Chen XL, Zhang YZ*,Li PY*. Biogeography of culturable marine bacteria from both poles reveals that ‘everything is not everywhere’ at the genomic level. Environ Microbiol, 2022, 24:98-109
3. Zhang Y#, Ding HT#, Jiang WX, Zhang X, Cao HY, Wang JP, Li CY, Huang F, Zhang XY, Chen XL, Zhang YZ*,Li PY*.Active site architecture of an acetyl xylan esterase indicates a novel cold adaptation strategy. J Biol Chem, 2021, 297:100841
4. Wang Y#,Li PY#, Zhang Y, Cao HY, Wang YJ, Li CY, Wang P, Su HN, Chen Y, Chen XL*, Zhang YZ*. 3,6-anhydro-L-galactose dehydrogenaseVvAHGD is a member of a new aldehyde dehydrogenase family and catalyzes by a novel mechanism with conformational switch of two catalytic residues cysteine 282 and glutamate 248. J Mol Biol, 2020, 432:2186-2203
5.Wang YJ, Jiang WX, Zhang YS, Cao HY, Zhang Y, Chen XL, Li CY, Wang P, Zhang YZ, Song XY*, Li PY*. Structural insight into chitin degradation and thermostability of a novel endochitinase from the glycoside hydrolase Family 18. Front Microbiol, 2019, 10:2457
6. Chen XL#, Zhao F#, Yue YS, Zhang XY, Zhang YZ,Li PY*. A new group of modular xylanases in glycoside hydrolase family 8 from marine bacteria. Appl Environ Microbiol, 2018, 84: e01785-18
7.Li PY#, Zhang Y#, Xie BB*, Zhang YQ, Hao J, Wang Y, Wang P, Li CY, Qin QL, Zhang XY, Su HN, Shi M, Zhang YZ, Chen XL*. Structural and mechanistic insights into the improvement of the halotolerance of a marine microbial esterase by increasing intra- and interdomain hydrophobic interactions.Appl Environ Microbiol, 2017, 83: e01286~17
8.Li PY#, Yao QQ#, Wang P, Zhang Y, Li Y, Zhang YQ, Hao J, Zhou BC, Chen XL*, Shi M, Zhang YZ, Zhang XY*.A novel subfamily esterase with a homoserine transacetylase-like fold but no transferase activity. Appl Environ Microbiol, 2017, 83：e00131~17
9.Li PY, Chen XL, Ji P, Li CY, Wang P, Zhang Y, Xie BB, Qin QL, Su HN, Zhou BC, Zhang YZ, Zhang XY*. Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family.J Biol Chem, 2015, 290: 11188~11198
10.Li PY, Ji P, Li CY, Zhang Y, Wang GL, Zhang XY, Xie BB, Qin QL, Chen XL, Zhou BC, Zhang YZ*. Structural basis for dimerization and catalysis of a novel esterase from the GTSAG motif subfamily of the bacterial hormone-sensitive lipase family.J Biol Chem, 2014, 289: 19031~19041
11.Li PY, Xie BB*, Zhang XY, Qin QL, Dang HY, Wang XM, Chen XL, Yu J, Zhang YZ*. Genetic structure of three fosmid-fragments encoding 16S rRNA genes of the Miscellaneous Crenarchaeotic Group (MCG): implications for physiology and evolution of marine sedimentary archaea.Environ Microbiol, 2012, 14: 467~479
所获专利
1.一种双酶催化N-乙酰-D-葡萄糖酸内酯生产2-酮基-3-脱氧-D-葡萄糖酸的方法，ZL202210367611.4，第二位
2. Method for producing 2-keto-3-deoxygluconate from 2-(acetylamino)-2-deoxy-D-gluconic acid by two enzymes, US 11,946,092 B2,第二位
3.一种海洋适冷酯酶及其编码基因E40与应用，ZL201510025698.7，第二位。
4.一种海洋酯酶及其编码基因E32与应用，ZL201510216087.0，第二位。
