高翔-微生物技术国家重点实验室

教育背景

博士起止时间：2007/09-2012/06 毕业院校：清华大学专业：生物物理

学士起止时间：2003/09-2007/06 毕业院校：山东大学专业：生物科学

工作经历

起止时间单位名称专业技术职务

2017/07−至今山东大学教授

2012/07−2017/07 耶鲁大学博士后

研究方向

1. 病原微生物致病的分子机制。

2. 肠道病原微生物、肠道菌群以及宿主之间相互作用的分子机制。

科研项目

1. 致病微生物Ⅲ型分泌系统结构与功能的研究，国家重点研发计划，政府间国际科技创新合作重点专项，2019-2022，在研，主持。

2. 沙门氏菌SopD效应蛋白家族功能的研究以及人伤寒沙门氏菌动物模型的优化，国家自然科学基金委面上项目，2018-2022，在研，主持。

3. 奶牛乳腺炎病学研究及新型疫苗研制，山东省自然科学基金重大基础研究项目，2019-2024，在研，参加。

4. 山东省泰山学者（青年项目），2017-2021，在研，主持。

5. 人体肠道微生物与人类健康，山东大学青年交叉科学创新群体，2020-2023，在研，主持。

6. 病原微生物的致病机制及抗感染药物的开发，山东大学国际科研合作种子基金，2019-2022，在研，主持。

代表性论文

(1)Huan Lian^#, Kun Jiang^#, Ming Tong^#, Zhe Chen, Xiaoyu Liu, Jorge E. Galan*, and Xiang Gao* (2021)Salmonella Effector Protein SopD targets Rab8 GTPase to positively and negative regulate the inflammatory response.Nature microbiology. 6（3）(^#, Co-first author)

(2)Kun Jiang^#; Yan Zhang^#; Zhe Chen^#; Dalei Wu;Jun Cai and Xiang Gao* (2020) Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin of Bacillus thuringiensis.Toxins 12: 1-15. (^#, Co-first author)

(3)Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki and Jorge E. Galan* (2017) Evolution of host adaptation in the Salmonella typhoid toxin.Nature Microbiology 12, 1592-1599.

(4)Peiyan Wang^#; Siji Li^#; Yingchi Zhao; Baohuan Zhang; Yunfei Li; Shengde Liu; Hongqiang Du; Lili Cao; Meiling Ou; Xiaohong Ye; Peng Li;Xiang Gao; Penghua Wang; Chunxia Jing; Feng Shao; Guang Yang* and Fuping You*(2019)The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.J Biol Chem 294(45): 16494-16508.

(5)Lili Cao^#; Shengde Liu^#; Yunfei Li; Guang Yang; Yujie Luo; Siji Li; Hongqiang Du; Yingchi Zhao; Dandan Wang; Jingxuan Chen; Zeming Zhang; Mo Li; Songying Ouyang;Xiang Gao; Yujie Sun; Zekun Wang; Long Yang; Rongtuan Lin; Penghua Wang and Fuping You*（2019）The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.Cell Host Microbe 26(3): 369-384.

(6)Casey Fowler; Shu-Jung Chang;Xiang Gao; Tobias Geiger; Gabrielle Stack and Jorge E. Galan* （2017）Emerging insights into the biology of typhoid toxin.Curr Opin Microbiol 35: 70-77. (invited review paper)

2017年之前发表文章

(1)Stefania Spanò^#,Xiang Gao^#, Sebastian Hannemann^#, Maria Lara-Tejero and Jorge E. Galan* (2016) A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.Cell Host & Microbe 19(2):216-26. (^#, Co-first author)

(2)Lingquan Deng^#, Jeongmin Song^#,Xiang Gao^#, Jiawei Wang, Hai Yu, Xi Chen, Nissi Varki, Yuko Naito-Matsui, Jorge Galan* and Ajit Varki* (2014) Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi.Cell 159(6):1290-9. (^#, Co-first author)

(3)Jeongmin Song^#,Xiang Gao^#and Jorge E. Galan*(2013) Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin.Nature 499(7458):350-4. (^#, Co-first author; Highlighted by F1000)

(4)Xiang Gao^#, Lijun Zhou^#, Xuyao Jiao, Feiran Lu, Chuangye Yan, Xin Zeng, Jiawei Wang and Yigong Shi* (2010) Mechanism of substrate recognition and transport by an amino acid antiporter.Nature 463, 828-832. (^#, Co-first author)

(5)Xiang Gao^#, Feiran Lu^#, Lijun Zhou^#, Shangyu Dang, Linfeng Sun, Xiaochun Li, Jiawei Wang and Yigong Shi* (2009) Structure and Mechanism of an Amino Acid Antiporter.Science 324, 1565-1568. (^#, Co-first author)

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