代表论文
I.转录因子靶标蛋白的结构功能研究和靶向分子发现领域
14. Song W, Zhuang J, Zhang N, Ren X, Xu W, Guo M, Diao X, Liu C, Jin J,Wu D*, Zhang Y*.SAR study of 1,2-benzisothiazole dioxide compounds that agonize HIF-2 stabilization and EPO production.Bioorg Med Chem. 2023, 77: 117041.（*共同通讯作者）
13. Sun X, Jing L, Li F, Zhang M, Diao X, Zhuang J, Rastinejad F,Wu D. Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.Proc Natl Acad Sci USA. 2022, 119: e2208804119.（独立通讯作者）
12. Ren X, Diao X, Zhuang J*,Wu D*. Structural basis for the allosteric inhibition of hypoxia-inducible factor 2 by belzutifan.Mol Pharmacol.2022, 102: 240-247.（*共同通讯作者）
11. Diao X, Ye F, Zhang M, Ren X, Tian X, Lu J, Sun X, Hou Z, Chen X, Li F, Zhuang J, Ding H, Peng C, Rastinejad F*, Luo C*,Wu D*. Identification of oleoylethanolamide as an endogenous ligand for HIF-3α.Nat Commun.2022, 13: 2529.（*共同通讯作者）
10. Zhuang J, Liu Q,Wu D*, Tie L*. Current strategies and progress for targeting the "undruggable" transcription factors.Acta Pharmacol Sin. 2022, 43: 2474-2481.（*共同通讯作者）
9. Li F, Song C, Zhang Y,Wu D. Structural overview and perspectives of the nuclear receptors, a major family as the direct targets for small-molecule drugs.Acta Biochim Biophys Sin (Shanghai). 2022, 54: 12-24.（独立通讯作者）[封面文章]
8.Wu D*, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim Y, Khorasanizadeh S, Rastinejad F*. Bidirectional modulation of HIF-2 activity through chemical ligands.Nat Chem Biol.2019, 15: 367-376. （*共同通讯作者）[获得F1000Prime推荐]
7. Chandra V#,Wu D#, Li S, Potluri N, Kim Y, Rastinejad F. The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission.Nat Commun.2017, 8: 868.（#共同第一作者）
6.Wu D, Rastinejad F. Structural characterization of mammalian bHLH-PAS transcription factors.Curr Opin Struct Biol.2017, 43: 1-9.
5. Smith SH, Jayawickreme C, Rickard DJ, Nicodeme E, Bui T, Simmons C, Coquery CM, Neil J, Pryor WM, Mayhew D, Rajpal DK, Creech K, Furst S, Lee J,Wu D, Rastinejad F, Willson TM, Viviani F, Morris DC, Moore JT, Cote-Sierra J. Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.J Invest Dermatol.2017, 137: 2110-2119.
4.Wu D, Su X, Potluri N, Kim Y, Rastinejad F. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.eLife.2016, 5: e18790.
3.Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors.Nature.2015, 524: 303-308. [在Nature同期News&Views栏目中被特别介绍，并获得F1000Prime推荐]
2.Wu D, Potluri N, Kim Y, Rastinejad F. Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.Mol Cell Biol.2013, 33: 4346-4356. [被编辑选为当期“意义显著”论文之一]
1.Wu D#, Nishimura N#, Kuo V, Fiehn O, Shahbaz S, Van Winkle L, Matsumura F, Vogel CF. Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice.Arterioscler Thromb Vasc Biol.2011, 31: 1260-1267. （#共同第一作者）[被编辑在同期社论中推荐]
II.其他药物靶标蛋白的结构功能研究和靶向分子发现领域
2.Wang J, Zhao J, Yan C, Xi C, Wu C, Zhao J, Li F, Ding Y, Zhang R, Qi S, Li X, Liu C, Hou W, Chen H, Wang Y,Wu D, Chen K, Jiang H, Huang H, Liu H. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial.Cell Metab.2022, 34: 667-680.
1. Xu M, Xu HH, Lin Y, Sun X, Wang LJ, Fang ZP, Su XH, Liang XJ, Hu Y, Liu ZM, Cheng Y, Wei Y, Li J, Li L, Liu HJ, Cheng Z, Tang N, Peng C, Li T, Liu T, Qiao L,Wu D, Ding YQ, Zhou WJ. LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis.Cell. 2019, 178: 1478-1492. [获得F1000Prime推荐]
III.生物合成相关酶的结构解析和催化机理研究领域
3. Ma L, Li F, Zhang X, Chen H, Huang Q, Su J, Liu X, Sun T, Fang B, Liu K, Tang D,Wu D, Zhang W, Du L, Li S. Development of MEMS directed evolution strategy for multiplied throughput and convergent evolution of cytochrome P450 enzymes.Sci China Life Sci.2022, 65: 550-560.
2. Zhang P, Zhang L, Jiang X, Diao XT, Li S, Li DD, Zhang Z, Fang J, Tang YJ,Wu D, Wu C, Li YZ. Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B.Commun Biol.2022, 5: 100.
1.Zhong L, Diao X, Zhang N, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y*,Wu D*, Bian X*. Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.Nat Commun.2021, 12: 296.（*共同通讯作者）[入选“有机化学和化学生物学”领域焦点论文]
