教育背景
1999/09-2004/06，山东大学，生命科学学院，博士
1992/09-1996/06，山东大学，微生物学系，学士
工作经历
2017/12 至今 山东大学，微生物改造技术全国重点实验室（研究院）教授、博导
2024/11 至今， 山东大学，服务山东办公室主任、合作发展部部长
2023/08-2024/10，山东大学，服务山东办副主任、合作发展部副部长
2017/12-2023/08，山东大学，微生物技术国家重点实验室（研究院）副主任（副院长）
2018/09-2020/09，历下区科技副区长
2017/01-2018/09，济宁高新技术产业开发区管委会科技副主任
2014/01-2016/12，禹城市人民政府挂职副市长
2013/09-2017/12，山东大学，生命科学学院，博士生导师
2011/12-2017/12，山东大学，生命科学学院，教授
2006/09-2011/12，山东大学，生命科学学院，副教授
2004/07-2006/09，山东大学，生命科学学院，讲师
1996/07-1999/09，济南科贝尔生物工程有限公司，助理工程师
研究方向
微生物生态、生理、生化及生信的研究
1.有机固态废弃物的生物降解与资源转化利用；
2.陆地半纤维素多糖及海洋多糖的高值化转化；
3.碳水化合物活性酶分子的智能设计。
科研项目
2025.11-2029.10，国家重点研发计划子课题2025YFA0922303-2，主持，在研
2025.10-2028.09，山东省自然科学基金面上项目ZR2025MS470,主持，在研
2020.12-2023.12，省重大科技创新工程课题2020CXGC010601，主持，结题
2019.10-2021.12，省科技厅其他计划重大专项项目SD2019ZZ018，主持，结题
2019.01-2021.12，省科技重大专项课题2019JZZY010411-5,主持，结题
2018.01-2021.12，国家自然科学基金面上项目31770054,主持，结题
2016.01-2020.12，国家重点研发计划子课题，2016YFD080061，主持，结题
2014.01-2017.12，国家基金一般项目31370111，主持，结题
2012.01-2015.12，国家基金一般项目31170071，主持，结题
2011.01-2012.12，科技部973计划子课题2011CB707401，主持，结题
2010.01-2012.12，国家基金一般项目30970092，主持，结题
2009.01-2009.12，国家基金一般项目30870044，主持，结题
2006.01-2008.12，国家基金一般项目30500007，主持，结题
代表性论文
1. Dou Z, Wu X, Wan L, Gong B,Wang L*. Structural proteomics-based deciphering of hydrophobic packing fingerprints informing protein thermostability in TIM barrels.J Chem Inf Model. 2026;66(14):8087–8101.
2. Zhang H, Dou Z, Wu X, Lai Y,Wang L*.Protein structural omics insights into microbial communities succession and alkaline adaptation during aerobic fermentation of thiourea residue. Environ Technol Innov. 2026;105143.
3. Bi W, Butardo VM Jr*,Wang L*. Coupling aerobic-anaerobic technology to reduce microbial resistance and maintain efficient degradation in sewage sludge treatment. Environ Technol Innov. 2026;43:105062.
4. Ma Z, Niu M, Song Y, Zhang L, Wang W, Wang T, Zhu J, Yang C, Xu L, Wu X, Xiao M, Zuo R, Li Y, Guo X, Zheng S, Xu Y,Wang L*, Li J*, Li Z*, Jiang X*. An interpretable, thermodynamics-based deep learning framework for predicting and optimizing drug membrane permeability.J Med Chem. 2026;69:9489–9506.
5. Yu X, Ma S, Wu X,Wang L*.Integrated omics analysis of the cellulose co-degradation network ofChaetomium thermophilum. Biotechnol Biofuels Bioprod. 2026;19(1):19.
6. Yang H, Li S, Yang X, Wu X, Zhao Y,Wang L*. Strategy development for enhancingTrichoderma longibrachiatumbiocontrol efficacy based on integrated functional omics.Bioresour Technol. 2025;436:133046.
7. Xu L, Ma Z, Zhu J, Liu Z, Song Y, Jiang X*,Wang L*.Interaction of polyethylene nanoplastics with the plasma, endoplasmic reticulum, Golgi apparatus, lysosome and endosome membranes: A molecular dynamics study. Ecotoxicol Environ Saf. 2025;302:118680.
8. Bi W, Butardo VM Jr, Sha G, Zhang H, Wu X,Wang L*. Microbial degradation and pollutant control in aerobic composting and anaerobic digestion of organic wastes: A review. Waste Manag. 2025;204:114894.
9. Liu M, Huang S, Yan P, Wu X, Yin H,Wang L*. Functional proteomic analysis ofStreptomycessp. F-3 reveals its potential to effectively degrade waste-yeast. Appl Microbiol Biotechnol.2025;109(1):157.
10. Zhang X, Zhang X, Liang B, Li X, Lv H, Zhou W, Wu X,Wang L*.Digging deeper to find the effect of long-term greenhouse cultivation with excessive fertilization and irrigation on the structure and assemblage of soil bacterial community. Geoderma. 2024;451:117087.
11. Dou Z, He J, Han C, Wu X, Wan L, Yang J, Zheng Y, Gong B,Wang L*. qProtein: Exploring physical features of protein thermostability based on structural proteomics.J Chem Inf Model. 2024;64(20):7885–7894.
12. Yang H, Wu X, Sun C,Wang L*.Unraveling the metabolic potential of biocontrol fungi through omics data: A key to enhancing large-scale application strategies. Acta Biochim Biophys Sin (Shanghai). 2024;56(6):825–832.
13. Sha G, Wu Z, Chen T, Zhang G, Shen J, Zhao X,Wang L*. Mechanisms for more efficient antibiotics and antibiotic resistance genes removal during industrialized treatment of over 200 tons of tylosin and spectinomycin mycelial dregs by integrated meta-omics. Bioresour Technol. 2024;401:130715.
14. Wu X, Zhao S, Tian Z, Han C, Jiang X,Wang L*. Dynamics of loops surrounding the active site architecture in GH5_2 subfamily TfCel5A for cellulose degradation. Biotechnol Biofuels Bioprod. 2023;16(1):154.
15. Zhang H, Dou Z, Bi W, Yang C, Wu X,Wang L*.Multi-omics study of sulfur metabolism affecting functional microbial community succession during aerobic solid-state fermentation. Bioresour Technol. 2023;387:129664.
16. Lai Y, Wu X, Zheng X, Li W,Wang L*. Insights into the keratin efficient degradation mechanism mediated by Bacillus sp. CN2 based on integrating functional degradomics. Biotechnol Biofuels Bioprod. 2023;16(1):59.
17. Yu X, Zhao Y, Yu J,Wang L*. Recent advances in the efficient degradation of lignocellulosic metabolic networks by lytic polysaccharide monooxygenase. Acta Biochim Biophys Sin (Shanghai). 2023.
18. Dou Z, Sun Y, Jiang X, Wu X, Li Y, Gong B,Wang L*. Data-driven strategies for the computational design of enzyme thermal stability: Trends, perspectives, and prospects. Acta Biochim Biophys Sin (Shanghai). 2023;55(3):343–355.
19. Wu X, Shi Z, Tian W, Liu M, Huang S, Liu X, Yin H*, Wang L*. A thermostable and CBM2-linked GH10 xylanase fromThermobifida fuscafor paper bleaching.Front Bioeng Biotechnol. 2022;10:939550.
20. Sha G, Zhang L, Wu X, Chen T, Tao X, Li X, Shen J, Chen G,Wang L*.Integrated meta-omics study on rapid tylosin removal mechanism and dynamics of antibiotic resistance genes during aerobic thermophilic fermentation of tylosin mycelial dregs. Bioresour Technol. 2022;351:127010.
21. Wu X, Zhang S, Zhao S, Dai L, Huang S, Liu X, Yu J*,Wang L*. Functional specificity of three α-arabinofuranosidases from different glycoside hydrolase families inAspergillus nigerAn76. J Agric Food Chem. 2022;70:5039–5048.
22. Sha G, Bi W, Zhang L, Chen T, Li X, Chen G,Wang L*. Dynamics and removal mechanisms of antibiotic and antibiotic resistance genes during the fermentation process of spectinomycin mycelial dregs: An integrated meta-omics study. J Hazard Mater. 2022;421:126822.
23. Zhang X, Hu Y, Liu G, Liu M, Li Z, Zhao J, Song X, Zhong Y, Qu Y,Wang L*, Qin Y*. The complex Tup1-Cyc8 bridges transcription factor ClrB and putative histone methyltransferase LaeA to activate the expression of cellulolytic genes. Mol Microbiol. 2022;117(5):1002–1022.
24. Zhang H, Wang W, Li Z, Yang C, Liang S,Wang L*.Planifilum fulgidumis the dominant functional microorganism in compost containing spent mushroom substrate. Sustainability. 2021;13:10002.
25. Lai Y, Li W, Wu X,Wang L*. A highly efficient protein degradation system inBacillussp. CN2: A functional-degradomics study. Appl Microbiol Biotechnol. 2021;105(2):707–723.
