教育背景
博士 起止时间：2015-2018毕业院校：哥本哈根大学 专业：生物化学
硕士 起止时间：2011-2014毕业院校：华中农业大学 专业：发酵过程
学士 起止时间：2007-2011毕业院校：华中农业大学 专业：生物工程
工作经历
起止时间 单位名称 专业技术职务
2018.9-2019.8，印第安纳大学,博士后
2019.9-2022.2，山东大学，博士后
2022.3-今，山东大学微生物技术研究院，研究员
研究方向
1. 微生物基因组稳定性维持机制
2. CRISPR-Cas工作机制
3. 微生物基因组编辑
科技部重点研发计划项目：新型基因大片段高效定点整合技术的研发及多元化应用, 2023-2028 (参与)
山东省高等学校青创科技支持计划：基于新型可编程核酸酶的高效微生物基因编辑技术的开发；2023-2025（主持）
科技部重点研发计划项目：极端微生物底盘细胞的设计与构建，2020-2025（参与）
国家自然科学基金青年基金项目：古菌首例B家族DNA聚合酶参与DNA形变损伤复制的分子机制。2021-2023（主持）
代表性论文
1.Feng X#*, Xu R#, Liao J, Zhao J, Zhang B, Xu X, Zhao P, Wang X, Yao J, Wang P, Wang X, Han W, She Q*. Flexible TAM requirement of TnpB enables efficient single-nucleotide editing with expanded targeting scope. Nat Commun. 2024 Apr 24;15(1):3464.
2. Blombach F, Sýkora M, Case J,Feng X, Baquero DP, Fouqueau T, Phung DK, Barker D, Krupovic M, She Q, Werner F*. Cbp1 and Cren7 form chromatin-like structures that ensure efficient transcription of long CRISPR arrays. Nat Commun. 2024 Feb 22;15(1):1620.
3. Zhao P, Bi X, Wang X,Feng X, Shen Y, Yuan G, She Q*. Rational design of unrestricted pRN1 derivatives and their application in the construction of a dual plasmid vector system forSaccharolobus islandicus. mLife. 2024; 3: 119–128.
4. Liu X, Sun M, Xu R, Shen Y, Huang Q*,Feng X*, She Q. Dissection of Functional Domains of Orc1-2, the Archaeal Global DNA Damage-Responsive Regulator. Int J Mol Sci. 2022 Nov 23;23(23):14609.
5.Feng X, Zhang B, Gao Z, Xu R, Liu X, Ishino S, Feng M, Shen Y, Ishino Y, She Q*. A Well-Conserved Archaeal B-Family Polymerase Functions as an Extender in Translesion Synthesis. mBio. 2022 Jan 18;13(1)
6.Feng X, Zhang B, Xu R, Gao Z, Liu X, Yuan G, Ishino S, Feng M, Shen Y, Ishino Y, She Q*. Enzymatic Switching Between Archaeal DNA Polymerases Facilitates Abasic Site Bypass. Front Microbiol. 2021 Dec 20;12:802670.
7.Feng X, Liu X, Xu R, Zhao R, Feng W, Liao J, Han W, She Q*.A unique B-Family DNA polymerase facilitating error-prone DNA damage tolerance in Crenarchaeota. Front Microbiol. 2020; 11:1585
8.Feng X, She Q*. Recombinant protein expression in Sulfolobus islandicus. Methods in Enzymology. 2021;659
9.Feng X, Huang Q., She Q.*, Crenarchaeal 3D genome: A prototypical chromosome architecture for eukaryotes, Cell, 2019, 179: 56-58
10. Sun M#,Feng X#, Liu Z, Han W, Liang YX, She Q*. An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea. Nucleic Acids Res. 2018 Jul 27;46(13):6697-6711
11.Feng X, Sun M, Han W, Liang YX, She Q*. A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea. Nucleic Acids Res. 2018 Aug 21;46(14):7085-7096
12. Peng W, Feng M,Feng X, Liang YX, She Q*. An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference. Nucleic Acids Res. 2015 Jan;43(1):406-17.
