教育背景:
2013.08-2016.07中国科学院大学 生物化学 博士
2010.09-2013.07 南开大学 生物化学与分子生物学 硕士
2006.09-2010.07 鲁东大学 生物科学 学士
工作经历:
2020.04-今 山东大学微生物技术研究院 副研究员
2018.10-2020.04 中国科学院青岛生物能源与过程研究所 助理研究员
2016.08-2018.10 中国科学院青岛生物能源与过程研究所 博士后
研究方向:
生物基化学品合成和微生物代谢调控
蛋白质翻译后修饰和功能研究
1.高碳原子经济性乙酰辅酶A衍生品底盘细胞的构建和调控机理研究,国家自然科学基金面上项目(22277068),54万元,2023.01-2026.12,主持。
2.生物基单体制备关键技术,国家重点研发计划(2022YFC2104700),50万元,2022.11-2026.10,骨干
3.山东大学青年学者未来计划,山东大学,50万元,2020.09-2025.08,主持。
4.HN材料生物合成高效底盘细胞的设计与构建,中央JW科学技术委员会,100万元,2019.01-2020.12,主持。
5.乙酰辅酶A衍生产品生物合成平台细胞的构建与调控机理研究,国家自然科学基金青年基金项目(21807101),27.5万元,2019.01-2021.12,主持。
6.大肠杆菌高效转化木糖合成乙醇酸的研究,中国博士后面上基金一等资助项目(2016M600564),8.0万元,2016.07-2018.07,主持。
7.木糖为底物高效合成乙醇酸的研究,青岛市博士后应用基础研究项目,5.0万元,2016.07-2018.07,主持。
代表性论文:
1. Likun Guo#,Min Liu#, Yujia Bi, Qingsheng Qi, Mo Xian, Guang Zhao*. Using a synthetic machinery to improve carbon yield with acetylphosphate as the core.Nature Communications. 2023,14:5286
2.Min Liu#, Meitong Huo#, Changshui Liu, Likun Guo, Yamei Ding, Qingjun Ma, Qingsheng Qi, Mo Xian*, Guang Zhao*. Lysine acetylation of Escherichia coli lactate dehydrogenase regulates enzyme activity and lactate synthesis.Frontiers in Bioengeering and Biotechnology. 2022,10:966062.
3.Min Liu#,∗, Meitong Huo#, Likun Guo, Yingxin Fu, Mo Xian, Qingsheng Qi, Wei Liu*, Guang Zhao*. Lysine acetylation decreases enzyme activity and protein level ofEscherichia colilactate dehydrogenase.Engineering Microbiology, 2022, 2:10045.
4.Min Liu#, Likun Guo#, Yingxin Fu, Meitong Huo, Qingsheng Qi, Guang Zhao*. Bacterial protein acetylation and its role in cellular physiology and metabolic regulation.Biotechnology Advances, 2021, 53:107842.
5.Min Liu, Yingxin Fu, Wenjie Gao, Mo Xian*, Guang Zhao*. Highly efficient biosynthesis of hypoxanthine inEscherichia coliand transcriptome-based analysis of the purine metabolism.ACS Synthetic Biology, 2020, 9(3):525-535.
6.Zhe Zhao, Mo Xian,Min Liu*, Guang Zhao*. Biochemical routes for uptake and conversion of xylose by microorganisms.Biotechnology for Biofuels, 2020, 13:21.
7.Min Liu, Yamei Ding, Mo Xian*, Guang Zhao*.Metabolic engineering of a xylose pathway for biotechnological production of glycolate inEscherichia coli.Microbial Cell Factories. 2018,17:51-62.
8.Yuhui Wang, Mo Xian, Xinjun Feng,Min Liu*, Guang Zhao*. Biosynthesis of ethylene glycol from d-xylose in recombinantEscherichia coli.Bioengineered. 2018, 9(1): 233-241.
9.Min Liu, Yamei Ding, Hailin Chen, Zhe Zhao, Huizhou Liu, Mo Xian*, Guang Zhao*. Improving the production of acetyl-CoA derived chemicals inEscherichia coliBL21(DE3) throughiclRandarcAdeletion.BMC Microbiology. 2017,17(1):10-19.
10.Min Liu, Xueping Han, Mo Xian, Yamei Ding, Huizhou Liu*, Guang Zhao*. Development of a 3-hydroxypropionate resistantEscherichia colistrain.Bioengineered. 2016,7(1):21-27.
11.Min Liu, Lan Yao, Mo Xian, Yamei Ding, Huizhou Liu, Guang Zhao. Deletion ofarcAincreased the production of acetyl-CoA-derived chemicals in recombinantEscherichia coli.Biotechnology letter, 2016, 38(4): 97-101.
12.Min Liu, Xinjun Feng, Yamei Ding, Guang Zhao, Huizhou Liu*, Mo Xian*. Metabolic engineering ofEscherichia colito improve recombinant protein production.Applied Microbiology and Biotechnology, 2015, 99(24): 10367-10377.
授权专利:
1.赵广,刘敏,咸漠,高文杰.一种生产黄嘌呤的重组菌及其构建方法和应用.专利号:CN110656073B
2.赵广,刘敏,咸漠,高文杰.一种合成次黄嘌呤的重组菌及其构建方法与应用。申请号:CN110656074B
3.赵广,刘敏,咸漠,富盈昕 一种提高嘌呤操纵子pur基因表达量的突变体及其构建方法与应用CN112980756B。
4.赵广,刘敏,霍美彤,王纪超,包子娴 一种乙酰化调控的乳酸脱氢酶突变体及其应用。CN114921429B。