微生物学、生物化学与分子生物学

刘晓倩

研究员
硕士生导师
个人简介 科研项目 学术论文

教育背景:

博士2011.08-2016.05德国莱布尼茨研究院衰老研究所,分子生物学

硕士2008.09-2011.07首都师范大学,生物化学与分子生物学

学士2004.09-2008.07青岛大学,生物技术专业

工作经历:

起止时间 单位名称 专业技术职务

2023.09-至今山东大学微生物技术研究院 研究员

2018.06- 2023.08中国科学院动物研究所 助理研究员

2016.06- 2018.01德国莱布尼茨研究院衰老研究所 博士后

研究方向:

1.大脑发育及退行性疾病

2.微生物群特别是肠道菌群和大脑神经发育与疾病的相互作用

科研项目:

1.2023.09-2028.09山东大学齐鲁青年学者计划学科建设经费,100万,主持

2.2020.01-2022.12国家自然科学基金青年项目,31900524,24万,主持,结题

3.2017-2021德国DFG基金项目,WA2627/2–2,MCPH1调控神经发育的机制研究,参与,结题

代表性论文:

一作/共一文章:

1.Liu X#, Liu Z#, Wu Z#, Ren J#, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence.Cell. 2023. 186: 1–18.

2.Wang C#, Yang K#,Liu X#, Wang S, Song M, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer.Research.2023 Jul 27;6:0192.

3.Zhang B#, Yan H#,Liu X#, Sun L#, Ma S, Wang S, Qu J*, Liu GH*, Zhang W*. SenoIndex: S100A8/S100A9 as a novel aging biomarker.Life Medicine. 2023.Volume 2, Issue 4.

4.Liu X#,Löhnert N#, Kristofova M, Qing X, Labisch J, Hofmann S, Ehrenberg S, Sannai M, Jörß T, Ori A, Godmann M, Wang ZQ*. The N-terminal BRCT domain determines MCPH1 function in brain development and fertility.Cell Death Dis. 2021. 12(2):143.

5.Li H#, Wu Z#,Liu X#, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W, Song M*, Song E*, Liu GH*. ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.Protein Cell. 2020. 11(9):688-695.

6.Liu X, Zong W, Li T, Wang Y, Xu X, Zhou ZW*, Wang ZQ*. The E3 ubiquitin ligase APC/CCdh1degrades MCPH1 to allow βTrCP2-Cdc25A-mediated mitotic entry and neurogenesis.The EMBO J. 2017. 36(24):e201694443.

7.Li J#*,Liu X#, Liao J, Tian J, Wang J, Wang X, Zhang J, Xu X*. MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint.JGeneticsGenomics. 2013.40 (11):575-578.

参与文章:

1.Zhang H, Li J, Yu Y, Ren J, Liu Q, Bao Z, Sun S,Liu X, Ma S, Liu Z, Yan K, Wu Z, Fan Y, Sun X, Zhang Y, Ji Q, Cheng F, Wei PH, Ma X, Zhang S, Xie Z, Niu Y, Wang WY, Han JD, Jiang T, Zhao G, Ji W, Belmonte JCI, Wang S*, Qu J*, Zhang W*, Liu GH*. Nuclear lamina erosin-induced resurrection of endogenous retroviruses underlies neuronal aging.Cell Reports. 2023.

2.He Y#, Ji Q#, Wu Z#, Cai Y#, Yin J, Zhang Y, Zhang S,Liu X, Zhang W, Liu GH*, Wang S*, Song M*, Qu J*. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis.Protein Cell. 2022.

3.Zhang S#, Wu Z#, Shi Y#, Wang S#, Ren J#, Yu Z, Huang D, Yan K, He Y,Liu X, Ji Q, Liu B, Liu Z, Qu J, Liu GH*, Ci W*, Wang X*, Zhang W*. FTO stabilizes MIS12 and counteracts senescence.Protein Cell. 2022. 13(12):954-960.

4.Geng L#, Zhang B#, Liu H#, Wang S#, Cai Y#, Yang K, Zou Z, Jiang X, Liu Z, Li W, Wu Z,Liu X, Chu Q, Liu GH*, Qu J*, Zhang W*. A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats.Life Medicine. 2022. lnac045

5.Hu H#, Ji Q#, Song M#, Ren J, Liu Z, Wang Z,Liu X, Yan K, Hu J, Wang S*, Zhang W*, Liu GH*, Qu J*. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin.Nucleic Acids Research. 2020. 48(11):6001-6018.

6.Bi S#, Liu Z#, Wu Z, Wang Z,Liu X, Wang S, Ren J, Zhang W*, Song M*, Liu GH*, Qu J*. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer.Protein Cell. 2020. 11(7):483-504.

7.Yan P#, Liu Z#, Song M#, Wu Z, Xu W, Li K, Ji Q, Wang S,Liu X, Yan K, Esteban CR, Ci W, Belmonte JCI, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming.Cell Reports. 2020. 32(1):107870.

8.Journiac N#, Gilabert-Juan J#, Cipriani S, Benit P,Liu X, Jacquier S, Faivre V, Delahaye-Duriez A, Csaba Z, Hourcade T, Melinte E, Lebon S, Violle-Poirsier C, Oury JF, Adle-Biassette H, Wang ZQ, Mani S, Rustin P, Gressens P, Nardelli J. Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.Cell Reports. 2020. 31(2):107506.

9.Geng L#, Liu Z#, Wang S, Sun S, Ma S,Liu X, Chan P, Sun L, Song M*, Zhang W*, Liu GH*, Qu J*. Low-dose quercetin positively regulates mouse healthspan.Protein Cell. 2019. 10 (10), 770-775.

10.Zhang X, Liu Z,Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W*, Song M*, Liu GH*, Qu J*. Telomere-Dependent and Telomere-Independent Roles of RAP1 in Regulating Human Stem Cell Homeostasis.Protein Cell. 2019. 10 (9): 649-667.

11.Ling C, Liu Z, Song M, Zhang W, Wang S,Liu X, Ma S, Sun S, Fu L, Chu Q,Belmonte JCI, Wang Z, Qu J*, Yuan Y*, Liu GH*. Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells.Protein Cell. 2019. 10(4):249-271.

综述以及评价文章

1. Aging Biomarker Consortium, et al. Biomarkers of aging.Sci China Life Sci. 2023. May;66(5):893-1066.(共一)

2.Liu X, Belmonte JCI, Zhang W, Liu GH*. A Beta-Galactosidase Kiss of Death for Senescent Cells.Cell Research. 2020. 30(7):556-557.

3.Liu X, Zhou ZW, Wang ZQ*. The DNA damage response molecule MCPH1 in brain development.Acta Biochimica et Biophysica Sinica. 2016. 48 (7):678-85.