微生物学、生物化学与分子生物学

卢宪芹

副研究员
硕士生导师
17860626008
个人简介 科研项目 学术论文 其他介绍

教育背景:

博士 2013.09-2018.07 山东大学 专业:微生物学

学士 2009.09-2013.07 山东大学 专业:生物技术


工作经历:

2022-09至 今,山东大学,微生物技术研究院,副研究员

2021-04至2022-08,齐鲁工业大学,生物工程学院,副教授

2018-09至2021-03,齐鲁工业大学,生物工程学院,讲师


研究方向:

1.木质纤维素的预处理及高值化转化:

(1)木质纤维素新型预处理工艺研究;

(2)木质纤维素生物、化学法转化制备高值化学品。

2.木质纤维素基纳米材料制备及应用研究:

(1)木质纤维素基纳米材料的生物、化学法制备及改性研究

(2)新型木质纤维素基纳米载体构筑及在医药和农业方面的应用

主要项目:

主持或参与多项国家级、省部级等项目:

(1) 2020-2022,糖基化修饰影响木质素-纤维素酶结合机制及酶理性改造,国家自然科学基金青年项目(31901269),主持

(2) 2019-2022,纤维素酶在木质素上的吸附规律和机制及弱木质素吸附性酶的构建,国家自然科学基金面上项目(31870562),参与

(3) 2024-2026,木质素-蛋白互作介导的木质素基纳米颗粒的可控构筑策略和机理研究,山东省自然科学基金面上项目(ZR2023MC092),主持

(4) 2019-2022,不同纤维素酶系在木质素上的吸附差异及机理研究,山东省自然科学基金博士基金(ZR2019BC022),主持

(5) 2019-2022,木质素-纤维素酶结合位点、构象及其分子机制研究,生物基材料与绿色造纸国家重点实验室主任基金项目(ZZ20190221),主持

(6) 2020-2021,木质素过氧化物酶功能基因筛选及酶学性质验证,齐鲁工业大学(山东省科学院)青年博士合作基金项目(2019BSHZ0026),主持

代表性论文:

(1)Yuqing Zhang#, Huiwen Li#, Qi Xin, Jian Zhao, Tao Xia*,Xianqin Lu*. The role of glycosylation in non-productive adsorption of cellulase to lignin isolated from pretreated corn stover. International Journal of Biological Macromolecules. 2024:130836.

(2)Xin Qi, Li Huiwen, Sun Wan, Li Xuezhi,Lu Xianqin*, Zhao Jian*. Lignin-xylan nanospheres prepared by green and quick method from lignocellulose and used as additive in PVA films. International Journal of Biological Macromolecules. 2024;261:129762

(3)Xianqin Lu, Xuezhi Li, Jian Zhao*. Improving enzymatic efficiency of β-glucosidases in cellulase system by altering its binding behavior to the insoluble substrate during bioconversion of lignocellulose. Bioresource Technology. 2024;391:129974.

(4)Meixiang Gao#, Qi Xin#, Wan Sun, Jiaqi Xiao*,Xianqin Lu*. Transformation of corn stover into furan aldehydes by one-pot reaction with acidic lithium bromide solution. International Journal of Molecular Sciences. 2022;23:14901.

(5)Jian Chen, Zhiqiang Pang, Yuqing Zhang, Jie Chu, Daolei Zhang,Xianqin Lu*; Cuihua Dong. Efficiently conversion of raw lignocellulose to levulinic acid and lignin nano-spheres in acidic lithium bromide-water system by two-step process. Bioresource Technology. 2022;343:126130.

(6)Xianqin Lu*,Yuqing Zhang, Jian Chen, Daolei Zhang, Cuihua Dong, Pang Zhiqiang, Tao Xia*. Preparation of tailored lignin nanospheres with specific size and tunable structure by self-assembly of lignin from corn straw. Industrial Crops and Products. 2021; 172:113993.

(7)Jian Chen;Xianqin Lu*;Zhiqiang Pang; Bingbing Li; Cuihua Dong*; Carbon nanospheres derived from crop residues by acidic lithium bromide hydrate treatment, BioResources, 2021, 16(4):7220.

(8)Xianqin Lu,Jian Chen, Junhua Lu, Shouguo Wang, Tao Xia*. Monosaccharides and carbon nanosphere obtained by acidic concentrated LiBr treatment of raw crop residues via optimizing the synthesis process. Bioresource Technology. 2020;310:123522.

(9)Xianqin Lu, Xingwang Liu, Wenqing Zhang, Xiaohan Wang, Shouguo Wang, Tao Xia*. The residue from the acidic concentrated lithium bromide treated crop residue as biochar to remove Cr (VI). Bioresource Technology. 2020;296:122348.

(10)Xianqin Lu, Can Li, Shengkui Zhang, Xiaohan Wang, Wenqing Zhang, Shouguo Wang*, Tao Xia*. Enzymatic sugar production from elephant grass and reed straw through pretreatments and hydrolysis with addition of thioredoxin-His-S.Biotechnology for Biofuels. 2019;12(1):297.

(11)Xianqin Lu, Xiaoting Feng, Xuezhi Li, Jian Zhao*. The adsorption properties of endoglucanase to lignin and their impact on hydrolysis. Bioresource technology. 2018;267:110-6.

(12)Xianqin Lu, Xiaoting Feng, Xuezhi Li, Jian Zhao*. Binding and hydrolysis properties of engineered cellobiohydrolases and endoglucanases. Bioresource technology. 2018;267:235-41.

(13)Xianqin Lu, Can Wang, Xuezhi Li, Jian Zhao*. Temperature and pH influence adsorption of cellobiohydrolase onto lignin by changing the protein properties. Bioresource technology. 2017;245(Pt A):819-25.

(14)Xianqin Lu, Can Wang, Xuezhi Li, Jian Zhao J*, Xuebing Zhao. Studying nonproductive adsorption ability and binding approach of cellobiohydrolase to lignin during bioconversion of lignocellulose. Energy & Fuels. 2017(31):14393−400.

(15)Xianqin Lu, Xiaoju Zheng, Xuezhi Li X, Jian Zhao*. Adsorption and mechanism of cellulase enzymes onto lignin isolated from corn stover pretreated with liquid hot water. Biotechnology for biofuels. 2016;9:118.

获奖

2023年入选山东大学青年学者未来计划

2023年 中国•山东(青岛)博士后创新创业成果大赛产业特别奖


专利

(1)卢宪芹;信琪;楚杰;王莹;利用葡萄籽制备功能性葡萄籽纳米球颗粒的方法及其产品,2023-04-18,中国,CN202111431570.2(专利)

(2)卢宪芹;陈建;董翠华;生物质在单相酸性溴化锂-水体系下制备乙酰丙酸的方法,2023-01-13,中国,CN202110558674.3(专利)

(3)卢宪芹;陈建;董翠华;一种生物质木质素纳米球壳的制备方法及应用, 2022-10-28,中国,CN202110560329.3(专利)

(4)卢宪芹;李兵兵;夏涛;一种玉米秸秆制备纳米木质素球的方法, 2022-07-29,中国,CN202110361161.3(专利)

(5)高美香;卢宪芹;夏涛;肖加奇;王其才;一种从生物质中高效分离高品质木质素的方法,2022-07-15,中国,CN202011166917.0 (专利)