研究方向
1.微生物新天然产物的理性挖掘与生物合成研究
2.基于生物合成/合成生物学的天然产物结构改造
3.天然产物药物前体的微生物制造与高产改造
科研项目
1.国家重点研发计划子课题,2022YFC2804102，组学信息驱动的深海药源分子的挖掘，2022-11至2025-10，50万元，在研,主持
2.国家重点研发计划子课题, 2019YFA0905402,聚酮类药物高效合成的分子机制与系统重塑, 2020-01至2024-12, 90万元,在研,主持
3.国家自然科学基金面上项目，31570039，定向挖掘含AHBA结构单元的新活性天然产物，2016/01‒2019/12，65万元，已结题，主持；
4.国家自然科学基金重点项目，81530091，安莎的新骨架发掘与药用功能导向的结构优化，2016.01-2020.12，273万元，已结题，参加
5．国家自然科学基金海外及港澳学者合作研究基金，31329005，溶杆菌的抗水稻病原活性成分离和生物合研究，2014/01-2017/12，200万元，已结题，参加；
6.国家自然科学基金青年项目，31100079，从隐性基因簇中发现新安莎霉素，2012/01-2014/12，25万元，已结题，主持；
代表性论文
1. Shi, P.; Li, Y.; Zhu, J.; Shen, Y.*;Wang, H.*, Targeted Discovery of the Polyene Macrolide Hexacosalactone A from Streptomyces by Reporter-Guided Selection of Fermentation Media. J Nat Prod 2021, 84 (7), 1924-1929.
2. Zhu, J.; Liu, M.; Deng, J.; Chen, W.; Zhu, D.; Duan, J.; Li, Y.;Wang, H.*; Shen, Y.*, The coupled reaction catalyzed by EchB and EchC lead to the formation of the common 2',3',5'-trihydroxy-benzene core in echosides biosynthesis. Biochem Biophys Res Commun 2021, 559, 62-69.
3. Wei, F.#; Wang, Z.#; Lu, C.; Li, Y.; Zhu, J.;Wang, H.*; Shen, Y., Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A-G. Organic letters 2019, 21 (19), 7818-7822.
4. Song, R.; Shi, H.; Zhu, J.;Wang, H.*; Shen, Y.*, A Single-Component Flavoenzyme Catalyzed Regioselective Halogenation of Pyrone in the Biosynthesis of Venemycins. ACS Chem Biol 2019, 14 (12), 2533-2537.
5. Li, Y.;Wang, H.; Liu, Y.; Jiao, Y.; Li, S.; Shen, Y.*; Du, L.*, Biosynthesis of the Polycyclic System in the Antifungal HSAF and Analogues from Lysobacter enzymogenes. Angewandte Chemie-International Edition 2018, 57 (21), 6221-6225.
6. Shi, G.#; Shi, N.#; Li, Y.; Chen, W.; Deng, J.; Liu, C.; Zhu, J.;Wang, H.*; Shen, Y.*, d-Alanylation in the Assembly of Ansatrienin Side Chain Is Catalyzed by a Modular NRPS. ACS Chemical Biology 2016, 11 (4), 876-881.
7. Liu, C.; Zhu, J.; Li, Y.; Zhang, J.; Lu, C.;Wang, H.*; Shen, Y.*, In Vitro Reconstitution of a PKS Pathway for the Biosynthesis of Galbonolides in Streptomyces sp. LZ35. Chembiochem 2015.
8. Li, S.; Li, Y.; Lu, C.; Zhang, J.; Zhu, J.;Wang, H.*; Shen, Y.*, Activating a Cryptic Ansamycin Biosynthetic Gene Cluster to Produce Three New Naphthalenic Octaketide Ansamycins with n-Pentyl and n-Butyl Side Chains. Organic letters 2015, 17 (15), 3706-9.
9.Wang, H.; Chen, Y.; Ge, L.; Fang, T.; Meng, J.; Liu, Z.; Fang, X.; Ni, S.; Lin, C.; Wu, Y.; Wang, M.; Shi, N.; He, H.; Hong, K.; Shen, Y.*, PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J Appl Microbiol 2013, 115 (1), 77-85.
10. Lu, C.; Li, Y.; Deng, J.; Li, S.; Shen, Y.;Wang, H.*; Shen, Y.*, Hygrocins C-G, cytotoxic naphthoquinone ansamycins from gdmAI-disrupted Streptomyces sp. LZ35. J Nat Prod 2013, 76 (12), 2175-2179.
11. Wang, H.; Geng, Z.; Zeng, Y.*; Shen, Y.*, Enriching plant microbiota for a metagenomic library construction. Environ Microbiol 2008, 10 (10), 2684-2691.
