微生物学、生物化学与分子生物学

毕明霞

副研究员
硕士生导师
个人简介 科研项目 学术论文

教育背景:

博士:2016.09-2019.06,青岛大学,生理学

硕士:2011.09-2014.06,青岛大学,神经生物学

学士:2006.09-2011.06,青岛大学,医学


工作经历:

2021.07-至今,山东大学微生物技术研究院,副研究员

2019.07-2021.06,青岛大学基础医学流动站,博士后


研究方向:

1.神经退行性疾病(如阿尔茨海默病、帕金森病)的病因及防治对策研究

2.神经退行性疾病肠道功能菌株挖掘以及与宿主互作的机制研究

主要项目:

1.2023.01-2026.12,国家自然科学基金面上项目,“索氏志贺氏菌与宿主和肠道菌群互作的机制及其在帕金森病中的作用”,54万,主持,在研

2.2022.01-2026.12,国家重点研发计划“变革性技术关键科学问题”专项,“微生物高通量培养与表征”子课题,90万,主持,在研

3.2023.01-2027.12,国家重点研发计划,“大型养殖动物肠道功能微生物组解析与调控”子课题,100万,主持,在研

4.2021.01-2023.12,山东省自然科学基金,青年基金,ZR2020QH125,15万,主持,结题

5.2020-07至2022-06,中国博士后科学基金,第67批面上资助,2020M671991,8万,主持,结题

代表性论文:

1.Bi M, Liu C, Wang Y, Liu SJ*. Therapeutic Prospect of New Probiotics in Neurodegenerative Diseases. Microorganisms. 2023 Jun 8;11(6):1527.

2.Bi M, Feng L, He J, Liu C, Wang Y, Jiang H*, Liu SJ*. Emerging insights between gut microbiome dysbiosis and Parkinson's disease: Pathogenic and clinical relevance. Ageing Res Rev. 2022 Dec;82:101759.

3.Bi M, Du X, Xiao X, Dai Y, Jiao Q, Chen X, Zhang L, Jiang H*. Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease. Redox Biol. 2021 Oct 14;47:102167.

4.Bi M, Du X, Jiao Q, Chen X, Jiang H*. Expanding the role of proteasome homeostasis in Parkinson’s disease: Beyond protein breakdown. Cell Death Dis. 2021 Feb 4;12(2):154.

5.Xiao X#,Bi M#, Jiao Q, Chen X, Du X*, Jiang H*. A new understanding of GHSR1a-independent of ghrelin activation. Ageing Res Rev. 2020 Dec;64:101187.

6.Bi M, Du X, Jiao Q, Liu Z, Jiang H*. α-Synuclein regulates iron homeostasis via preventing parkin-mediated DMT1 ubiquitylation in Parkinson’s disease models. ACS Chem Neurosci. 2020 Jun 3;11(11):1682-1691.

7.Bi M, Kang S, Du X, Jiao Q, Jiang H*. Association between SNCA rs356220 polymorphism and Parkinson’s disease: A meta-analysis. Neurosci Lett. 2020 Jan 19;717:134703.

8.Kang S#,Bi M#, Du X, Jiao Q, Jiang H*. Association of the rs1611115 polymorphism in DBH gene with Parkinson’s disease: a meta-analysis. Neurol Sci. 2018 Dec;39(12):2085-2089.

9.Bi M, Jiao Q, Du X, Jiang H*. Glut9-mediated urate uptake is responsible for its protective effects on dopaminergic neurons in Parkinson’s disease models. Front Mol Neurosci. 2018 Jan 26;11:21.

10.Wang J#,Bi M#, Liu H, Song N, Xie J. The protective effect of lactoferrin on ventral mesencephalon neurons against MPP + is not connected with its iron binding ability. Sci Rep. 2015 Jun 2;5:10729.