教育背景
博士 1998.09-2012.06 山东大学 微生物学
硕士 1989.09-1992.06 山东师范大学 植物学
学士 1985.09-1989.06 山东师范大学 生物学
工作经历
1992.07-1995.08 山东省农科院棉花研究中心 实习研究员
1995.09-1998.09 山东省农科院棉花研究中心 助理研究员
1998.10-2002.08 山东大学生命科学学院 讲师
2002.09-2004.08 山东大学微生物技术国家重点实验室 副教授
2004.09-2012.08 山东大学微生物技术国家重点实验室 四级教授
2012.09-今 山东大学微生物技术国家重点实验室 三级教授
研究方向
海洋微生物学与海洋微生物技术：主要挖掘参与海洋中有机物降解和循环的海洋微生物新型酶，分析酶的结构与功能并开发其在工农业领域的应用。
科研项目
1.《深海热液区耐热细菌参与胶原蛋白降解和羟脯氨酸再循环利用的生命过程、机制及相关酶资源应用潜力评价》，国家基金委-山东省联合基金项目，2021-2024， 282万，项目负责人。
2. 《深海热液区微生物与功能基因应用潜力评价》，科技部国家重点研发计划课题，2018-2021，405万，项目负责人。
3. 《新型海洋微生物酶制剂的创制及系列高值化海洋生物制 品制备技术》，山东省重大科技创新工程，2019-2022,200万，子课题负责人。
4. 《海洋细菌来源的PL14家族褐藻胶裂解酶的性质、结构和催化机制研究》，国家自然科学基金面上项目，2019-2022，59万，项目负责人。
5. 《诱导细菌胞外蛋白酶表达的胞外诱导物和细胞膜上的信号感应受体研究》，国家自然科学基金面上项目，2017-2020，68万，项目负责人。
代表性论文
1.Yan Wang, Peng Wang, Hai-Yan Cao, Hai-Tao Ding, Hai-Nan Su, Shi-Cheng Liu, Guangfeng Liu, Xia Zhang, Chun-Yang Li, Ming Peng, Fuchuan Li , Shengying Li, Yin Chen,Xiu-Lan Chen* & Yu-Zhong Zhang*. Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis.Nature Communications.2022, 13:566.
2.Yan Wang, Hai-Nan Su, Hai-Yan Cao, Si-Min Liu, Shi-Cheng Liu, Xia Zhang, Peng Wang, Chun-Yang Li, Yu-Zhong Zhang, Xi-Ying Zhang* &Xiu-Lan Chen*. Mechanistic Insight into the Fragmentation of Type I Collagen Fibers into Peptides and Amino Acids by a Vibrio Collagenase.Applied and Environmental Microbiology. 2022, 88(7):e01677-21.
3.Yang Yu, Jie Yang, Zhao-Jie Teng, Li-Yuan Zheng, Qi Sheng, Ping-Yi Li, Hui-Hui Fu, Chun-Yang Li, Yin Chen, Yu-Zhong Zhang, Jun-Mei Ding* &Xiu-Lan Chen*. D-Alanine Metabolism via D-Ala Aminotransferase by a Marine Gammaproteobacterium, Pseudoalteromonas sp. Strain CF6-2.Applied and Environmental Microbiology. 2022, 88(3): e02219-21.
4.Zhao-Jie Teng#, Peng Wang#,Xiu-Lan Chen#, Richard Guillonneau, Chun-Yang Li, Song-Bao Zou, Jun Gong , Kai-Wen Xu, Lin Han, Chao Wang, David J. Scanlan , Yin Chen and Yu-Zhong Zhang*. Acrylate protects a marine bacterium from grazing by a ciliate predator.Nature Microbiology.2021,6(11):1351-U17.
5.Fei Xu#, Fang Dong#, Xiao-Hui Sun, Hai-Yan Cao, Hui-Hui Fu, Chun-Yang Li, Xi-Ying Zhang, Andrew McMinn, Yu-Zhong Zhang, Peng Wang* &Xiu-Lan Chen*. Mechanistic Insights into Substrate Recognition and Catalysis of a New Ulvan Lyase of Polysaccharide Lyase Family 24.Applied and Environmental Microbiology.2021, 87(12): e00412-21.
6.Bai-Lu Tang#, Jie Yang#,Xiu-Lan Chen#, Peng Wang#, Hui-Lin Zhao, Hai-Nan Su, Chun-Yang Li, Yang Yu, Shuai Zhong, Lei Wang, Ian Lidbury, Hai-Tao Ding, Min Wang, Andrew McMinn, Xi-Ying Zhang, Yin Chen & Yu-Zhong Zhang*, A predator-prey interaction between a marinePseudoalteromonassp. and Gram-positive bacteria,Nature Communications. 2020, 11 (1): 285.
7.Yue Wang,Ping-Yi Li,Yi Zhang,Hai-Yan Cao,Yan-Jun Wang,Chun-Yang Li,Peng Wang,Hai-Nan Su,Yin Chen,Xiu-Lan Chen* &Yu-Zhong Zhang*, 3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248,Journal of Molecular Biology. 2020, 432 (7): 2186-2203
8.Fang Zhao, Hai-Yan Cao, Long-Sheng Zhao, Yi Zhang, Chun-Yang Li, Yu-Zhong Zhang, Ping-Yi Li, Peng Wang*,Xiu-Lan Chen*, A Novel Subfamily Endo-β-1,4-glucanase in Glycoside Hydrolase Family 10.Applied and Environmental Microbiology.2019, 85(18): e01029-19.
9.Xiu-Lan Chen#, Fang Zhao#, Yong-Sheng Yue, Xi-Ying Zhang, Yu-Zhong Zhang, Ping-Yi Li*, A New Group of Modular Xylanases in Glycoside Hydrolase Family 8 from Marine Bacteria.Applied and Environmental Microbiology. 2018, 84(23): e01785-18.
10.Fei Xu, Fang Dong, Peng Wang, Hai-Yan Cao, Chun-Yang Li, Ping-Yi Li, Xiu-Hua Pang, Yu-Zhong Zhang,Xiu-Lan Chen*, Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6.Journal of Biological Chemistry. 2017, 292: 4457-4468.
