科研项目
1. 2020.01-2023.12:L-苹果酸醌氧化还原酶在铜绿假单胞菌乙酸代谢与绿脓菌素产生中的作用研究,国家自然基金,项目号:31970056
2. 2020.01-2024.12:生物反应器监控系统重构与工业生物过程优化,国家重点研发计划子课题,课题号:2019YFA0904800
3. 2019.07-2024.06:合成细胞对污染物的趋化和聚集研究,国家重点研发计划子课题,课题号:2018YFA0901200
4. 2017.01-2020.12:阴沟肠杆菌中乙酸代谢溢流消除机制研究,国家自然基金,项目号:31670041
5. 2015.01-2018.12:Pseudomonas putida KT2440中2,3-丁二醇分解代谢机制研究,国家自然基金,项目号:31470164
6. 2013.01-2016.12:微生物乳酸代谢调控蛋白LldR的结构及机制研究,国家自然基金,项目号:31270090
7. 2012.01-2015.12:施氏假单胞菌中新型NAD非依赖性L-乳酸脱氢酶研究,国家自然基金,项目号:31170052
8. 2019.01-2020.12:重组大肠杆菌利用玉米芯水解液高效生产木糖酸,山东省科技发展计划项目,项目号:2019GSF107034
9. 2017.01-2018.12:代谢工程改造地衣芽孢杆菌利用生物质资源高效生产乙偶姻,广东省科技发展计划项目,项目号:2017A010105020
10. 2014.01-2016.12:生物法生产聚合级meso-2,3-丁二醇研究,山东省科技发展计划项目,项目号:2014GSF121030
代表性论文
1. Cao MH, Jiang TT, Li P, Zhang YP, Guo ST, Meng WS, Lü CJ*, Zhang W,Xu P, Gao C,Ma CQ*, Pyruvate production from whey powder by metabolic engineered Klebsiella oxytocaJ. Agric. Food Chem. 2020, 68, 15275−15283
2. Zhang YP, Guo ST, Wang YX, Liang X, Xu P, Gao C,Ma CQ*, Production of D-xylonate from corn cob hydrolysate by a metabolically engineeredEscherichia coli strain,ACS Sustainable Chem. Eng. 2019, 7, 2160−2168
3. Liu QY, Liu YD, Kang ZQ, Xiao D, Gao C, Xu P*,Ma CQ*, 2,3-Butanediol catabolism ofPseudomonas aeruginosa PAO1,Environ. Microbiol. 2018, 20, 3927-40
4. Yan JX, Xu J, Cao MH, Li Z, Xu CP, Wang XY, Yang CY, Xu P, Gao C, Ma CQ*, Engineering of glycerol utilization inGluconobacter oxydans 621H for biocatalyst preparation in a low-cost way,Microb. Cell Fact. 2018, 17, 158
5. Ge YS,Li K,Li LX,Gao C*, Zhang LJ,Ma CQ*, Xu P,Contracted but effective: production of enantiopure 2,3-butanediol by thermophilic and GRASBacillus licheniformis,Green Chem. 2016, 18, 4693
6. Zhang LJ, Liu QY, Ge YS, Li LX, Gao C, Xu P,Ma CQ *, Biotechnological production of acetoin, a biobased platform chemical, from a lignocellulosic resource by metabolically engineeredEnterobacter cloacae,Green Chem. 2016, 18,1560-70
7. Gao C, Li Z, Zhang LJ, Wang C, Li K,Ma CQ*, Xu P*, An artificial enzymatic reaction cascade for a cell-free bio-system based on glycerol,Green Chem. 2015, 17, 804-7
8. Li LX§, Li K§, Wang Y, Chen C, Xu YQ, Zhang LJ, Han BB, Gao C,Ma CQ*, Xu P*, Metabolic engineering ofEnterobacter cloacae for high-yield production of enantiopure (2R,3R)-2,3-butanediol from lignocellulose-derived sugars,Metab. Eng. 2015, 28, 19-27
9. Gao C, Wang YJ, Zhang YX, Lv M, Dou PP, Xu P,Ma CQ*, NAD-Independent L-lactate dehydrogenase required for L-lactate utilization inPseudomonas stutzeri A1501,J Bacteriol.2015,197(13),2239-47
10. Xu YQ, Chu HP, Gao C, Tao F, Zhou ZL, Li K, Li LX,Ma CQ*, Xu P*, Systematic metabolic engineering ofEscherichia coli for high-yield production of fuel bio-chemical 2,3-butanediol,Metab. Eng.2014, 23, 22–33
11. Xu YQ, Tao F,Ma CQ*, Xu P, Newconstitutive vectors: useful genetic engineering tools for biocatalysis.Appl. Environ. Microbiol. 2013,79,2836–40
12. Li LX, Zhang LJ, Li K, Wang Y, Gao C, Han BB,Ma CQ*, Xu P,A newly isolatedBacillus licheniformis strain thermophilically produces 2,3-butanediol, a platform and fuel bio-chemical. Biotechnol Biofuels. 2013,6,123
13. Zheng ZJ, Sheng BB,Ma CQ*, Zhang HW,Gao C, Su F,Xu P,The relative catalyticefficiency ofldhL- andldhD-encoded products iscrucial for the optical purity of lacticacid produced by Lactobacillus strains, Appl. Environ. Microbiol. 2012,78, 3480-83
14. Gao C, Hu CH,Zheng ZJ,Ma CQ*, Jiang TY, Dou PP, Zhang W, Che B, Wang YJ, Lv M, Xu P,Lactateutilizationisregulated by the FadR-typeregulator LldR inPseudomonas aeruginosa,J. Bacteriol. 2012,194, 2687-2692
15. Liu Z,Ma CQ*, Gao C, Xu P,Efficient utilization of hemicellulose hydrolysate for propionic acid production usingPropionibacterium acidipropionici. Bioresour. Technol. 2012,114, 711-714
16. Li LX,Wang Y, Zhang LJ,Ma CQ*, Wang AL, Tao F, Xu P, Biocatalytic production of (2S,3S)-2,3-butanediol from diacetyl using whole cells of engineeredEscherichia coli.Bioresour. Technol. 2012,115, 111-116
获奖情况
1. 利用生物质可再生资源制造高值化合物2,3-丁二醇及其衍生物,2010年,中国石油和化学工业联合会科学技术发明一等奖
2. 代谢工程构建2,3-丁二醇高产菌株的研究,2015年度山东省优秀博士学位论文指导奖
3. 恶臭假单胞菌中戊二酸代谢途径及调控机制研究,2020年度山东省优秀博士学位论文指导奖
所获专利
1. 一株可利用木质纤维素原料发酵生产2,3-丁二醇的嗜热地衣芽孢杆菌,中国发明专利:ZL 201310473033.3
2. 一株阴沟肠杆菌及其在制备2,3-丁二醇中的应用,中国发明专利:ZL 201110119442.4
3. 一种生产手性纯(2S,3S)-2,3-丁二醇的方法,中国发明专利:ZL 201110021066.5
4. 一种生产2,3-丁二醇的方法及其专用地衣芽孢杆菌,中国发明专利:ZL 201110369152.5
5. 一种由葡萄糖制备( 2S,3S)-2,3-丁二醇和(3S)-乙偶姻的方法,中国发明专利:ZL 201110247505.4
6. 一种利用L-赖氨酸2-单加氧酶和δ-戊酰胺水解酶催化制备5-氨基戊酸的方法,中国发明专利:ZL 201310241389.4
7. 一株基因工程菌及其在生产(2R,3R)-2,3-丁二醇中的应用,中国发明专利:ZL 2014100314730.9